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Items: 1 to 20 of 247

1.

Leucine induces myofibrillar protein accretion in cultured skeletal muscle through mTOR dependent and -independent control of myosin heavy chain mRNA levels.

Haegens A, Schols AM, van Essen AL, van Loon LJ, Langen RC.

Mol Nutr Food Res. 2012 May;56(5):741-52. doi: 10.1002/mnfr.201100695.

PMID:
22648621
2.

Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats.

Lynch CJ, Hutson SM, Patson BJ, Vaval A, Vary TC.

Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E824-35.

PMID:
12217901
3.

Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway.

Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR.

J Nutr. 2000 Oct;130(10):2413-9.

4.

Oral administration of leucine stimulates phosphorylation of 4E-bP1 and S6K 1 in skeletal muscle but not in liver of diabetic rats.

Yoshizawa F, Hirayama S, Sekizawa H, Nagasawa T, Sugahara K.

J Nutr Sci Vitaminol (Tokyo). 2002 Feb;48(1):59-64.

PMID:
12026190
5.

Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine.

Lang CH, Frost RA, Bronson SK, Lynch CJ, Vary TC.

Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1283-94. doi: 10.1152/ajpendo.00676.2009. Epub 2010 Apr 13.

6.

Leucine-stimulated mTOR signaling is partly attenuated in skeletal muscle of chronically uremic rats.

Chen Y, Sood S, McIntire K, Roth R, Rabkin R.

Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E873-81. doi: 10.1152/ajpendo.00068.2011. Epub 2011 Jul 26.

PMID:
21791619
7.

Passive mechanical forces upregulate the fast myosin heavy chain IId/x via integrin and p38 MAP kinase activation in a primary muscle cell culture.

Hanke N, Kubis HP, Scheibe RJ, Berthold-Losleben M, Hüsing O, Meissner JD, Gros G.

Am J Physiol Cell Physiol. 2010 Apr;298(4):C910-20. doi: 10.1152/ajpcell.00265.2009. Epub 2010 Jan 13.

PMID:
20071689
8.

Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by alpha-ketoisocaproate.

Yoshizawa F, Sekizawa H, Hirayama S, Yamazaki Y, Nagasawa T, Sugahara K.

J Nutr Sci Vitaminol (Tokyo). 2004 Feb;50(1):56-60.

PMID:
15228219
9.
10.

Activation of mammalian target of rapamycin signaling in skeletal muscle of neonatal chicks: effects of dietary leucine and age.

Deng H, Zheng A, Liu G, Chang W, Zhang S, Cai H.

Poult Sci. 2014 Jan;93(1):114-21. doi: 10.3382/ps.2013-03287.

PMID:
24570430
11.

Human soleus and vastus lateralis muscle protein metabolism with an amino acid infusion.

Carroll CC, Fluckey JD, Williams RH, Sullivan DH, Trappe TA.

Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E479-85. Epub 2004 Oct 26.

PMID:
15507532
12.

Rheb, an activator of target of rapamycin, in the blackback land crab, Gecarcinus lateralis: cloning and effects of molting and unweighting on expression in skeletal muscle.

MacLea KS, Abuhagr AM, Pitts NL, Covi JA, Bader BD, Chang ES, Mykles DL.

J Exp Biol. 2012 Feb 15;215(Pt 4):590-604. doi: 10.1242/jeb.062869.

13.

Supplementing L-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs.

Yin Y, Yao K, Liu Z, Gong M, Ruan Z, Deng D, Tan B, Liu Z, Wu G.

Amino Acids. 2010 Nov;39(5):1477-86. doi: 10.1007/s00726-010-0612-5. Epub 2010 May 15.

PMID:
20473536
14.

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC.

J Biol Chem. 2004 Aug 27;279(35):36553-61. Epub 2004 Jun 22.

15.

Post-exercise whey protein hydrolysate supplementation induces a greater increase in muscle protein synthesis than its constituent amino acid content.

Kanda A, Nakayama K, Fukasawa T, Koga J, Kanegae M, Kawanaka K, Higuchi M.

Br J Nutr. 2013 Sep 28;110(6):981-7. doi: 10.1017/S0007114512006174. Epub 2013 Feb 7.

PMID:
23388415
16.

Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice.

Welle S, Burgess K, Mehta S.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E567-72. doi: 10.1152/ajpendo.90862.2008. Epub 2009 Jan 13.

17.

Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes.

Pham PT, Heydrick SJ, Fox HL, Kimball SR, Jefferson LS Jr, Lynch CJ.

J Cell Biochem. 2000 Sep 7;79(3):427-41.

PMID:
10972980
18.

Leucine improves growth performance of intrauterine growth retardation piglets by modifying gene and protein expression related to protein synthesis.

Xu W, Bai K, He J, Su W, Dong L, Zhang L, Wang T.

Nutrition. 2016 Jan;32(1):114-21. doi: 10.1016/j.nut.2015.07.003. Epub 2015 Jul 26.

PMID:
26454700
19.

Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1.

Park IH, Erbay E, Nuzzi P, Chen J.

Exp Cell Res. 2005 Sep 10;309(1):211-9.

PMID:
15963500
20.

Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance.

Balage M, Dupont J, Mothe-Satney I, Tesseraud S, Mosoni L, Dardevet D.

J Nutr Biochem. 2011 Mar;22(3):219-26. doi: 10.1016/j.jnutbio.2010.02.001. Epub 2010 Jun 16.

PMID:
20558053

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