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Items: 1 to 20 of 127

1.

A shortcut from GPCR signaling to Rac-mediated actin cytoskeleton through an ELMO/DOCK complex.

Xu X, Jin T.

Small GTPases. 2012 Jul-Sep;3(3):183-5. doi: 10.4161/sgtp.20271. Epub 2012 May 31.

2.

ELMO proteins transduce G protein-coupled receptor signal to control reorganization of actin cytoskeleton in chemotaxis of eukaryotic cells.

Xu X, Jin T.

Small GTPases. 2017 Jun 22:1-9. doi: 10.1080/21541248.2017.1318816. [Epub ahead of print]

PMID:
28641070
3.

ELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis.

Wang Y, Xu X, Pan M, Jin T.

J Cancer. 2016 May 12;7(8):973-83. doi: 10.7150/jca.15118. eCollection 2016.

4.

A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis.

Yan J, Mihaylov V, Xu X, Brzostowski JA, Li H, Liu L, Veenstra TD, Parent CA, Jin T.

Dev Cell. 2012 Jan 17;22(1):92-103. doi: 10.1016/j.devcel.2011.11.007.

5.

Cell adhesion controlled by adhesion G protein-coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo-Dock.

Hernández-Vásquez MN, Adame-García SR, Hamoud N, Chidiac R, Reyes-Cruz G, Gratton JP, Côté JF, Vázquez-Prado J.

J Biol Chem. 2017 Jul 21;292(29):12178-12191. doi: 10.1074/jbc.M117.780304. Epub 2017 Jun 9.

PMID:
28600358
6.

Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO.

deBakker CD, Haney LB, Kinchen JM, Grimsley C, Lu M, Klingele D, Hsu PK, Chou BK, Cheng LC, Blangy A, Sondek J, Hengartner MO, Wu YC, Ravichandran KS.

Curr Biol. 2004 Dec 29;14(24):2208-16.

7.

Dock180-ELMO cooperation in Rac activation.

Lu M, Ravichandran KS.

Methods Enzymol. 2006;406:388-402.

PMID:
16472672
8.
9.
10.

Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay.

Brzostowski JA, Sawai S, Rozov O, Liao XH, Imoto D, Parent CA, Kimmel AR.

J Cell Sci. 2013 Oct 15;126(Pt 20):4614-26. doi: 10.1242/jcs.122952. Epub 2013 Jul 31.

11.

BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module.

Park D, Tosello-Trampont AC, Elliott MR, Lu M, Haney LB, Ma Z, Klibanov AL, Mandell JW, Ravichandran KS.

Nature. 2007 Nov 15;450(7168):430-4.

PMID:
17960134
12.

C-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEF.

Akakura S, Kar B, Singh S, Cho L, Tibrewal N, Sanokawa-Akakura R, Reichman C, Ravichandran KS, Birge RB.

J Cell Physiol. 2005 Jul;204(1):344-51.

PMID:
15700267
13.

The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.

Patel M, Chiang TC, Tran V, Lee FJ, Côté JF.

J Biol Chem. 2011 Nov 11;286(45):38969-79. doi: 10.1074/jbc.M111.274191. Epub 2011 Sep 19.

14.

Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility.

Para A, Krischke M, Merlot S, Shen Z, Oberholzer M, Lee S, Briggs S, Firtel RA.

Mol Biol Cell. 2009 Jan;20(2):699-707. doi: 10.1091/mbc.E08-09-0899. Epub 2008 Nov 26.

15.

An Elmo-like protein associated with myosin II restricts spurious F-actin events to coordinate phagocytosis and chemotaxis.

Isik N, Brzostowski JA, Jin T.

Dev Cell. 2008 Oct;15(4):590-602. doi: 10.1016/j.devcel.2008.08.006.

16.

An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling.

Patel M, Margaron Y, Fradet N, Yang Q, Wilkes B, Bouvier M, Hofmann K, Côté JF.

Curr Biol. 2010 Nov 23;20(22):2021-7. doi: 10.1016/j.cub.2010.10.028. Epub 2010 Oct 28.

17.

Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.

Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, Macara IG, Madhani H, Fink GR, Ravichandran KS.

Nat Cell Biol. 2002 Aug;4(8):574-82.

PMID:
12134158
18.

The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1.

Santy LC, Ravichandran KS, Casanova JE.

Curr Biol. 2005 Oct 11;15(19):1749-54.

19.

Rac regulation of chemotaxis and morphogenesis in Dictyostelium.

Park KC, Rivero F, Meili R, Lee S, Apone F, Firtel RA.

EMBO J. 2004 Oct 27;23(21):4177-89. Epub 2004 Oct 7.

20.

Identification of two signaling submodules within the CrkII/ELMO/Dock180 pathway regulating engulfment of apoptotic cells.

Tosello-Trampont AC, Kinchen JM, Brugnera E, Haney LB, Hengartner MO, Ravichandran KS.

Cell Death Differ. 2007 May;14(5):963-72. Epub 2007 Feb 16.

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