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Items: 1 to 20 of 270

1.

Water extract of Hedyotis Diffusa Willd suppresses proliferation of human HepG2 cells and potentiates the anticancer efficacy of low-dose 5-fluorouracil by inhibiting the CDK2-E2F1 pathway.

Chen XZ, Cao ZY, Chen TS, Zhang YQ, Liu ZZ, Su YT, Liao LM, Du J.

Oncol Rep. 2012 Aug;28(2):742-8. doi: 10.3892/or.2012.1834. Epub 2012 May 25.

PMID:
22641337
2.

Anticancer Effects of 1,3-Dihydroxy-2-Methylanthraquinone and the Ethyl Acetate Fraction of Hedyotis Diffusa Willd against HepG2 Carcinoma Cells Mediated via Apoptosis.

Li YL, Zhang J, Min D, Hongyan Z, Lin N, Li QS.

PLoS One. 2016 Apr 11;11(4):e0151502. doi: 10.1371/journal.pone.0151502. eCollection 2016.

3.

The monoclonal antibody CH12 augments 5-fluorouracil-induced growth suppression of hepatocellular carcinoma xenografts expressing epidermal growth factor receptor variant III.

Jiang H, Dong Q, Luo X, Shi B, Wang H, Gao H, Kong J, Zhang J, Li Z.

Cancer Lett. 2014 Jan 1;342(1):113-20. doi: 10.1016/j.canlet.2013.08.038. Epub 2013 Sep 2.

PMID:
24007863
4.

In Silico Identification and In Vitro and In Vivo Validation of Anti-Psychotic Drug Fluspirilene as a Potential CDK2 Inhibitor and a Candidate Anti-Cancer Drug.

Shi XN, Li H, Yao H, Liu X, Li L, Leung KS, Kung HF, Lu D, Wong MH, Lin MC.

PLoS One. 2015 Jul 6;10(7):e0132072. doi: 10.1371/journal.pone.0132072. eCollection 2015.

5.
6.

Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes.

Tin AS, Sundar SN, Tran KQ, Park AH, Poindexter KM, Firestone GL.

Anticancer Drugs. 2012 Apr;23(4):370-9. doi: 10.1097/CAD.0b013e32834f6ea8.

PMID:
22185819
7.

Ethyl acetate extraction from a Chinese herbal formula, Jiedu Xiaozheng Yin, inhibits the proliferation of hepatocellular carcinoma cells via induction of G0/G1 phase arrest in vivo and in vitro.

Cao Z, Lin W, Huang Z, Chen X, Zhao J, Zheng L, Ye H, Liu Z, Liao L, Du J.

Int J Oncol. 2013 Jan;42(1):202-10. doi: 10.3892/ijo.2012.1703. Epub 2012 Nov 16.

PMID:
23165653
8.

Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels.

Baiz D, Pozzato G, Dapas B, Farra R, Scaggiante B, Grassi M, Uxa L, Giansante C, Zennaro C, Guarnieri G, Grassi G.

Biochimie. 2009 Mar;91(3):373-82. doi: 10.1016/j.biochi.2008.10.015. Epub 2008 Nov 12.

PMID:
19041685
10.

SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation.

Zhao P, Chen L, Li LH, Wei ZF, Tong B, Jia YG, Kong LY, Xia YF, Dai Y.

BMC Cancer. 2014 Dec 19;14:987. doi: 10.1186/1471-2407-14-987.

11.

A novel anticancer agent, SKLB70359, inhibits human hepatic carcinoma cells proliferation via G0/G1 cell cycle arrest and apoptosis induction.

Dai XY, Zeng XX, Peng F, Han YY, Lin HJ, Xu YZ, Zhou T, Xie G, Deng Y, Mao YQ, Yu LT, Yang L, Zhao YL.

Cell Physiol Biochem. 2012;29(1-2):281-90. doi: 10.1159/000337609. Epub 2012 Mar 1.

12.

The anti-tumor effect and bioactive phytochemicals of Hedyotis diffusa willd on ovarian cancer cells.

Zhang L, Zhang J, Qi B, Jiang G, Liu J, Zhang P, Ma Y, Li W.

J Ethnopharmacol. 2016 Nov 4;192:132-139. doi: 10.1016/j.jep.2016.07.027. Epub 2016 Jul 15.

PMID:
27426510
13.

Total alkaloids of Rubus aleaefolius Poir. inhibit the STAT3 signaling pathway leading to suppression of proliferation and cell cycle arrest in a mouse model of hepatocellular carcinoma.

Zhao J, Lin W, Cao Z, Liu L, Zhuang Q, Zhong X, Hong Z, Peng J.

Oncol Rep. 2013 Sep;30(3):1309-14. doi: 10.3892/or.2013.2585. Epub 2013 Jul 3.

PMID:
23828071
14.

Total alkaloids of Rubus aleaefolius Poir inhibit hepatocellular carcinoma growth in vivo and in vitro via activation of mitochondrial-dependent apoptosis.

Zhao J, Chen X, Lin W, Wu G, Zhuang Q, Zhong X, Hong Z, Peng J.

Int J Oncol. 2013 Mar;42(3):971-8. doi: 10.3892/ijo.2013.1779. Epub 2013 Jan 18.

PMID:
23338043
15.

Sorafenib enhances the chemotherapeutic efficacy of S-1 against hepatocellular carcinoma through downregulation of transcription factor E2F-1.

Zhai JM, Yin XY, Lai YR, Hou X, Cai JP, Hao XY, Liang LJ, Zhang LJ.

Cancer Chemother Pharmacol. 2013 May;71(5):1255-64. doi: 10.1007/s00280-013-2120-2. Epub 2013 Feb 23.

PMID:
23435877
16.

Differentiation-inducing factor-1 enhances 5-fluorouracil action on oral cancer cells inhibiting E2F1 and thymidylate synthase mRNAs accumulation.

Sprio AE, Di Scipio F, Ceppi P, Salamone P, Di Carlo F, Scagliotti GV, Papotti M, Ceccarelli A, Berta GN.

Cancer Chemother Pharmacol. 2012 Apr;69(4):983-9. doi: 10.1007/s00280-011-1790-x. Epub 2011 Dec 4.

PMID:
22139443
17.

Extract of Hedyotis diffusa Willd influences murine leukemia WEHI-3 cells in vivo as well as promoting T- and B-cell proliferation in leukemic mice.

Lin CC, Kuo CL, Lee MH, Hsu SC, Huang AC, Tang NY, Lin JP, Yang JS, Lu CC, Chiang JH, Chueh FS, Chung JG.

In Vivo. 2011 Jul-Aug;25(4):633-40.

PMID:
21709007
18.

Evaluation of the effects of the water-soluble total flavonoids from Isodon lophanthoides var.gerardianus (Benth.) H. Hara on apoptosis in HepG2 cell: Investigation of the most relevant mechanisms.

Feng CP, Tang HM, Huang S, Hou SZ, Liang J, Huang W, Lai XP.

J Ethnopharmacol. 2016 Jul 21;188:70-9. doi: 10.1016/j.jep.2016.04.042. Epub 2016 Apr 29.

PMID:
27132715
19.

Hedyotis diffusa Willd extract inhibits the growth of human glioblastoma cells by inducing mitochondrial apoptosis via AKT/ERK pathways.

Zhang Y, Xie RF, Xiao QG, Li R, Shen XL, Zhu XG.

J Ethnopharmacol. 2014 Dec 2;158 Pt A:404-11. doi: 10.1016/j.jep.2014.10.017. Epub 2014 Oct 30.

PMID:
25456437
20.

Suberoylanilide hydroxamic acid enhances chemosensitivity to 5-fluorouracil in hepatocellular carcinoma via inhibition of thymidylate synthase.

Liao B, Liang H, Chen J, Liu Q, Zhang B, Chen X.

Tumour Biol. 2015 Dec;36(12):9347-56. doi: 10.1007/s13277-015-3497-9. Epub 2015 Jun 25.

PMID:
26108995

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