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Items: 1 to 20 of 103


TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.

Zhang N, Bevan MJ.

Nat Immunol. 2012 May 27;13(7):667-73. doi: 10.1038/ni.2319.


TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.

Sledzińska A, Hemmers S, Mair F, Gorka O, Ruland J, Fairbairn L, Nissler A, Müller W, Waisman A, Becher B, Buch T.

PLoS Biol. 2013 Oct;11(10):e1001674. doi: 10.1371/journal.pbio.1001674. Epub 2013 Oct 8.


A two-hit model of autoimmunity: lymphopenia and unresponsiveness to TGF-β signaling.

L'Huillier A, Ren G, Shi Y, Zhang J.

Cell Mol Immunol. 2012 Sep;9(5):369-70. doi: 10.1038/cmi.2012.25. Epub 2012 Aug 13. No abstract available.


Suppressing autoimmunity by TGF-β: not just through T(reg) cells.

He MX, He YW.

Cell Mol Immunol. 2012 Sep;9(5):371-2. doi: 10.1038/cmi.2012.24. Epub 2012 Aug 13. No abstract available.


Truncated form of TGF-βRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice.

Ishigame H, Mosaheb MM, Sanjabi S, Flavell RA.

J Immunol. 2013 Jun 15;190(12):6340-50. doi: 10.4049/jimmunol.1300397. Epub 2013 May 17.


TGF-β puts the brakes on homeostatic proliferation.

Surh CD, Sprent J.

Nat Immunol. 2012 Jun 19;13(7):628-30. doi: 10.1038/ni.2345. No abstract available.


TGF-{beta} signaling of human T cells is modulated by the ancillary TGF-{beta} receptor endoglin.

Schmidt-Weber CB, Letarte M, Kunzmann S, Rückert B, Bernabéu C, Blaser K.

Int Immunol. 2005 Jul;17(7):921-30. Epub 2005 Jun 20.


Innate immune cell CD45 regulates lymphopenia-induced T cell proliferation.

Saunders AE, Shim YA, Johnson P.

J Immunol. 2014 Sep 15;193(6):2831-42. doi: 10.4049/jimmunol.1302681. Epub 2014 Aug 11.


A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor β receptor signaling.

Gu AD, Zhang S, Wang Y, Xiong H, Curtis TA, Wan YY.

Immunity. 2015 Jan 20;42(1):68-79. doi: 10.1016/j.immuni.2014.12.019. Epub 2014 Dec 25.


Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy.

Zhang L, Yu Z, Muranski P, Palmer DC, Restifo NP, Rosenberg SA, Morgan RA.

Gene Ther. 2013 May;20(5):575-80. doi: 10.1038/gt.2012.75. Epub 2012 Sep 13.


Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development.

Ouyang W, Beckett O, Ma Q, Li MO.

Immunity. 2010 May 28;32(5):642-53. doi: 10.1016/j.immuni.2010.04.012. Epub 2010 May 13.


Co-stimulation of T cell proliferation by transforming growth factor-beta 1.

Lee HM, Rich S.

J Immunol. 1991 Aug 15;147(4):1127-33.


Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway.

Grainger JR, Smith KA, Hewitson JP, McSorley HJ, Harcus Y, Filbey KJ, Finney CA, Greenwood EJ, Knox DP, Wilson MS, Belkaid Y, Rudensky AY, Maizels RM.

J Exp Med. 2010 Oct 25;207(11):2331-41. doi: 10.1084/jem.20101074. Epub 2010 Sep 27.


The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.

Salmond RJ, Brownlie RJ, Morrison VL, Zamoyska R.

Nat Immunol. 2014 Sep;15(9):875-883. doi: 10.1038/ni.2958. Epub 2014 Aug 10.


Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity.

Filippi CM, Juedes AE, Oldham JE, Ling E, Togher L, Peng Y, Flavell RA, von Herrath MG.

Diabetes. 2008 Oct;57(10):2684-92. doi: 10.2337/db08-0609. Epub 2008 Aug 8.


IL-2 mediates CD4+ T cell help in the breakdown of memory-like CD8+ T cell tolerance under lymphopenic conditions.

Le Saout C, Villard M, Cabasse C, Jacquet C, Taylor N, Hernandez J.

PLoS One. 2010 Sep 10;5(9):e12659. doi: 10.1371/journal.pone.0012659.


TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β.

Arumugam V, Bluemn T, Wesley E, Schmidt AM, Kambayashi T, Malarkannan S, Riese MJ.

J Leukoc Biol. 2015 Nov;98(5):703-12. doi: 10.1189/jlb.2HIMA1214-578R. Epub 2015 Jul 7.


Memory-like CD8+ and CD4+ T cells cooperate to break peripheral tolerance under lymphopenic conditions.

Le Saout C, Mennechet S, Taylor N, Hernandez J.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19414-9. doi: 10.1073/pnas.0807743105. Epub 2008 Nov 25.

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