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Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase η recruitment to DNA damage sites.

Whitehurst CB, Vaziri C, Shackelford J, Pagano JS.

J Virol. 2012 Aug;86(15):8097-106. doi: 10.1128/JVI.00588-12. Epub 2012 May 23.


The Translesion Polymerase Pol η Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1.

Dyson OF, Pagano JS, Whitehurst CB.

J Virol. 2017 Sep 12;91(19). pii: e00600-17. doi: 10.1128/JVI.00600-17. Print 2017 Oct 1.


The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity.

Kumar R, Whitehurst CB, Pagano JS.

J Virol. 2014 Jun;88(11):6411-22. doi: 10.1128/JVI.00536-14. Epub 2014 Mar 26.


Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen.

Hishiki A, Hashimoto H, Hanafusa T, Kamei K, Ohashi E, Shimizu T, Ohmori H, Sato M.

J Biol Chem. 2009 Apr 17;284(16):10552-60. doi: 10.1074/jbc.M809745200. Epub 2009 Feb 10.


The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity.

Whitehurst CB, Ning S, Bentz GL, Dufour F, Gershburg E, Shackelford J, Langelier Y, Pagano JS.

J Virol. 2009 May;83(9):4345-53. doi: 10.1128/JVI.02195-08. Epub 2009 Feb 25.


DNA-damage tolerance mediated by PCNA*Ub fusions in human cells is dependent on Rev1 but not Polη.

Qin Z, Lu M, Xu X, Hanna M, Shiomi N, Xiao W.

Nucleic Acids Res. 2013 Aug;41(15):7356-69. doi: 10.1093/nar/gkt542. Epub 2013 Jun 12.


The herpes simplex virus 1 UL36USP deubiquitinase suppresses DNA repair in host cells via deubiquitination of proliferating cell nuclear antigen.

Dong X, Guan J, Zheng C, Zheng X.

J Biol Chem. 2017 May 19;292(20):8472-8483. doi: 10.1074/jbc.M117.778076. Epub 2017 Mar 27.


NMR mapping of PCNA interaction with translesion synthesis DNA polymerase Rev1 mediated by Rev1-BRCT domain.

Pustovalova Y, Maciejewski MW, Korzhnev DM.

J Mol Biol. 2013 Sep 9;425(17):3091-105. doi: 10.1016/j.jmb.2013.05.029. Epub 2013 Jun 7.


A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks.

Durando M, Tateishi S, Vaziri C.

Nucleic Acids Res. 2013 Mar 1;41(5):3079-93. doi: 10.1093/nar/gkt016. Epub 2013 Jan 23.


Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork.

Brown S, Niimi A, Lehmann AR.

Cell Cycle. 2009 Mar 1;8(5):689-92. Epub 2009 Mar 25.


Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.

Ghosal G, Leung JW, Nair BC, Fong KW, Chen J.

J Biol Chem. 2012 Oct 5;287(41):34225-33. doi: 10.1074/jbc.M112.400135. Epub 2012 Aug 17.


Regulation of monoubiquitinated PCNA by DUB autocleavage.

Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W, Gygi SP, Ploegh HL, Bernards R, D'Andrea AD.

Nat Cell Biol. 2006 Apr;8(4):339-47. Epub 2006 Mar 12.


Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.

Lee KY, Yang K, Cohn MA, Sikdar N, D'Andrea AD, Myung K.

J Biol Chem. 2010 Apr 2;285(14):10362-9. doi: 10.1074/jbc.M109.092544. Epub 2010 Feb 9.


The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.

Tellier-Lebegue C, Dizet E, Ma E, Veaute X, Coïc E, Charbonnier JB, Maloisel L.

PLoS Genet. 2017 Dec 27;13(12):e1007119. doi: 10.1371/journal.pgen.1007119. eCollection 2017 Dec. Erratum in: PLoS Genet. 2018 Feb 14;14 (2):e1007236.


Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination.

Watanabe K, Tateishi S, Kawasuji M, Tsurimoto T, Inoue H, Yamaizumi M.

EMBO J. 2004 Oct 1;23(19):3886-96. Epub 2004 Sep 9.


PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.

Krijger PH, van den Berk PC, Wit N, Langerak P, Jansen JG, Reynaud CA, de Wind N, Jacobs H.

DNA Repair (Amst). 2011 Oct 10;10(10):1051-9. doi: 10.1016/j.dnarep.2011.08.005. Epub 2011 Sep 1.


Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.

Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, Li X, Liu Z, Zhang T, Huang M, Friedberg EC, Tang TS, Guo C.

Nucleic Acids Res. 2013 Dec;41(22):10312-22. doi: 10.1093/nar/gkt793. Epub 2013 Sep 12.


Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage.

Wit N, Buoninfante OA, van den Berk PC, Jansen JG, Hogenbirk MA, de Wind N, Jacobs H.

Nucleic Acids Res. 2015 Jan;43(1):282-94. doi: 10.1093/nar/gku1301. Epub 2014 Dec 10.


PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ.

Dieckman LM, Washington MT.

DNA Repair (Amst). 2013 May 1;12(5):367-76. doi: 10.1016/j.dnarep.2013.02.007. Epub 2013 Mar 15.

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