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Items: 1 to 20 of 105

1.

Structural, mechanistic and regulatory studies of serine palmitoyltransferase.

Lowther J, Naismith JH, Dunn TM, Campopiano DJ.

Biochem Soc Trans. 2012 Jun 1;40(3):547-54. doi: 10.1042/BST20110769. Review.

PMID:
22616865
2.
3.

The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutations.

Beattie AE, Gupta SD, Frankova L, Kazlauskaite A, Harmon JM, Dunn TM, Campopiano DJ.

Biomed Res Int. 2013;2013:194371. doi: 10.1155/2013/194371. Epub 2013 Sep 23.

4.

Role of a conserved arginine residue during catalysis in serine palmitoyltransferase.

Lowther J, Charmier G, Raman MC, Ikushiro H, Hayashi H, Campopiano DJ.

FEBS Lett. 2011 Jun 23;585(12):1729-34. doi: 10.1016/j.febslet.2011.04.013. Epub 2011 Apr 18.

5.

Acceleration of the substrate Calpha deprotonation by an analogue of the second substrate palmitoyl-CoA in Serine Palmitoyltransferase.

Ikushiro H, Fujii S, Shiraiwa Y, Hayashi H.

J Biol Chem. 2008 Mar 21;283(12):7542-53. doi: 10.1074/jbc.M706874200. Epub 2007 Dec 31.

6.

The external aldimine form of serine palmitoyltransferase: structural, kinetic, and spectroscopic analysis of the wild-type enzyme and HSAN1 mutant mimics.

Raman MC, Johnson KA, Yard BA, Lowther J, Carter LG, Naismith JH, Campopiano DJ.

J Biol Chem. 2009 Jun 19;284(25):17328-39. doi: 10.1074/jbc.M109.008680. Epub 2009 Apr 17.

7.

Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation.

Lowther J, Yard BA, Johnson KA, Carter LG, Bhat VT, Raman MC, Clarke DJ, Ramakers B, McMahon SA, Naismith JH, Campopiano DJ.

Mol Biosyst. 2010 Sep;6(9):1682-93. doi: 10.1039/c003743e. Epub 2010 May 5. Erratum in: Mol Biosyst. 2011 Dec;7(12):3375.

8.

The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis.

Yard BA, Carter LG, Johnson KA, Overton IM, Dorward M, Liu H, McMahon SA, Oke M, Puech D, Barton GJ, Naismith JH, Campopiano DJ.

J Mol Biol. 2007 Jul 27;370(5):870-86. Epub 2007 May 10.

PMID:
17559874
9.

Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum.

Ikushiro H, Islam MM, Okamoto A, Hoseki J, Murakawa T, Fujii S, Miyahara I, Hayashi H.

J Biochem. 2009 Oct;146(4):549-62. doi: 10.1093/jb/mvp100. Epub 2009 Jun 29.

PMID:
19564159
10.

The chemical basis of serine palmitoyltransferase inhibition by myriocin.

Wadsworth JM, Clarke DJ, McMahon SA, Lowther JP, Beattie AE, Langridge-Smith PR, Broughton HB, Dunn TM, Naismith JH, Campopiano DJ.

J Am Chem Soc. 2013 Sep 25;135(38):14276-85. doi: 10.1021/ja4059876. Epub 2013 Sep 11.

PMID:
23957439
11.

Multifunctional role of His159in the catalytic reaction of serine palmitoyltransferase.

Shiraiwa Y, Ikushiro H, Hayashi H.

J Biol Chem. 2009 Jun 5;284(23):15487-95. doi: 10.1074/jbc.M808916200. Epub 2009 Apr 5.

12.

A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity.

Gable K, Gupta SD, Han G, Niranjanakumari S, Harmon JM, Dunn TM.

J Biol Chem. 2010 Jul 23;285(30):22846-52. doi: 10.1074/jbc.M110.122259. Epub 2010 May 26.

13.

Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism.

Hanada K.

Biochim Biophys Acta. 2003 Jun 10;1632(1-3):16-30. Review. Erratum in: Biochim Biophys Acta. 2004 Jun 1;1682(1-3):128.

PMID:
12782147
14.

Bacterial serine palmitoyltransferase: a water-soluble homodimeric prototype of the eukaryotic enzyme.

Ikushiro H, Hayashi H, Kagamiyama H.

Biochim Biophys Acta. 2003 Apr 11;1647(1-2):116-20. Review.

PMID:
12686119
15.

The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein.

Raman MC, Johnson KA, Clarke DJ, Naismith JH, Campopiano DJ.

Biopolymers. 2010 Sep;93(9):811-22. doi: 10.1002/bip.21482.

PMID:
20578000
16.
17.
18.

HSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship.

Bode H, Bourquin F, Suriyanarayanan S, Wei Y, Alecu I, Othman A, Von Eckardstein A, Hornemann T.

Hum Mol Genet. 2016 Mar 1;25(5):853-65. doi: 10.1093/hmg/ddv611. Epub 2015 Dec 17.

PMID:
26681808
19.

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

Hornemann T, Wei Y, von Eckardstein A.

Biochem J. 2007 Jul 1;405(1):157-64.

20.

PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism.

Bourquin F, Capitani G, Grütter MG.

Protein Sci. 2011 Sep;20(9):1492-508. doi: 10.1002/pro.679. Review.

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