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Items: 1 to 20 of 101

1.

DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions.

Saribasak H, Maul RW, Cao Z, Yang WW, Schenten D, Kracker S, Gearhart PJ.

J Exp Med. 2012 Jun 4;209(6):1075-81. doi: 10.1084/jem.20112234. Epub 2012 May 21.

2.

DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.

Delbos F, Aoufouchi S, Faili A, Weill JC, Reynaud CA.

J Exp Med. 2007 Jan 22;204(1):17-23. Epub 2006 Dec 26.

3.

DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.

Schrader CE, Linehan EK, Ucher AJ, Bertocci B, Stavnezer J.

DNA Repair (Amst). 2013 Dec;12(12):1087-93. doi: 10.1016/j.dnarep.2013.09.002. Epub 2013 Sep 29.

4.

MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.

Wilson TM, Vaisman A, Martomo SA, Sullivan P, Lan L, Hanaoka F, Yasui A, Woodgate R, Gearhart PJ.

J Exp Med. 2005 Feb 21;201(4):637-45. Epub 2005 Feb 14.

5.

Competitive repair pathways in immunoglobulin gene hypermutation.

Reynaud CA, Delbos F, Faili A, Guéranger Q, Aoufouchi S, Weill JC.

Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):613-9. doi: 10.1098/rstb.2008.0206. Review.

6.

Somatic hypermutation at A/T-rich oligonucleotide substrates shows different strand polarities in Ung-deficient or -proficient backgrounds.

Zivojnovic M, Delbos F, Girelli Zubani G, Julé A, Alcais A, Weill JC, Reynaud CA, Storck S.

Mol Cell Biol. 2014 Jun;34(12):2176-87. doi: 10.1128/MCB.01452-13. Epub 2014 Apr 7.

7.

Analysis of Ig gene hypermutation in Ung(-/-)Polh(-/-) mice suggests that UNG and A:T mutagenesis pathway target different U:G lesions.

Li S, Zhao Y, Wang JY.

Mol Immunol. 2013 Mar;53(3):214-7. doi: 10.1016/j.molimm.2012.08.009. Epub 2012 Sep 4.

PMID:
22960197
8.

DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes.

Maul RW, MacCarthy T, Frank EG, Donigan KA, McLenigan MP, Yang W, Saribasak H, Huston DE, Lange SS, Woodgate R, Gearhart PJ.

J Exp Med. 2016 Aug 22;213(9):1675-83. doi: 10.1084/jem.20151227. Epub 2016 Jul 25.

9.

Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification.

Martomo SA, Yang WW, Wersto RP, Ohkumo T, Kondo Y, Yokoi M, Masutani C, Hanaoka F, Gearhart PJ.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8656-61. Epub 2005 Jun 6.

10.

129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation.

McDonald JP, Frank EG, Plosky BS, Rogozin IB, Masutani C, Hanaoka F, Woodgate R, Gearhart PJ.

J Exp Med. 2003 Aug 18;198(4):635-43.

11.

Hijacked DNA repair proteins and unchained DNA polymerases.

Saribasak H, Rajagopal D, Maul RW, Gearhart PJ.

Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):605-11. doi: 10.1098/rstb.2008.0188. Review.

12.

Somatic hypermutation: subverted DNA repair.

Martomo SA, Gearhart PJ.

Curr Opin Immunol. 2006 Jun;18(3):243-8. Epub 2006 Apr 17. Review.

PMID:
16616477
13.

DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.

Masuda K, Ouchida R, Takeuchi A, Saito T, Koseki H, Kawamura K, Tagawa M, Tokuhisa T, Azuma T, O-Wang J.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13986-91. Epub 2005 Sep 19.

14.
15.

The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.

Frieder D, Larijani M, Collins C, Shulman M, Martin A.

Mol Cell Biol. 2009 Sep;29(18):5148-57. doi: 10.1128/MCB.00647-09. Epub 2009 Jul 13.

16.

Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation.

Poltoratsky V, Woo CJ, Tippin B, Martin A, Goodman MF, Scharff MD.

Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7976-81. Epub 2001 Jun 26.

17.

A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination.

Martomo SA, Yang WW, Gearhart PJ.

J Exp Med. 2004 Jul 5;200(1):61-8.

18.

Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse.

Delbos F, De Smet A, Faili A, Aoufouchi S, Weill JC, Reynaud CA.

J Exp Med. 2005 Apr 18;201(8):1191-6. Epub 2005 Apr 11.

19.

Altered spectra of hypermutation in DNA repair-deficient mice.

Winter DB, Gearhart PJ.

Philos Trans R Soc Lond B Biol Sci. 2001 Jan 29;356(1405):5-11. Review.

20.

Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation.

Rajagopal D, Maul RW, Ghosh A, Chakraborty T, Khamlichi AA, Sen R, Gearhart PJ.

J Exp Med. 2009 Jun 8;206(6):1237-44. doi: 10.1084/jem.20082514. Epub 2009 May 11.

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