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Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance.

Calfee CS, Gallagher D, Abbott J, Thompson BT, Matthay MA; NHLBI ARDS Network.

Crit Care Med. 2012 Jun;40(6):1731-7. doi: 10.1097/CCM.0b013e3182451c87.


Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients.

Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD.

Crit Care Med. 2010 Sep;38(9):1845-51. doi: 10.1097/CCM.0b013e3181eaa5bf.


Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis.

Ricciuto DR, dos Santos CC, Hawkes M, Toltl LJ, Conroy AL, Rajwans N, Lafferty EI, Cook DJ, Fox-Robichaud A, Kahnamoui K, Kain KC, Liaw PC, Liles WC.

Crit Care Med. 2011 Apr;39(4):702-10. doi: 10.1097/CCM.0b013e318206d285.


von Willebrand factor and angiopoietin-2: toward an acute lung injury endothelial endophenotype?

Meyer NJ, Christie JD.

Crit Care Med. 2012 Jun;40(6):1966-7. doi: 10.1097/CCM.0b013e31824c8fad. No abstract available.


Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients.

Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS.

Am J Respir Crit Care Med. 2013 Apr 1;187(7):736-42. doi: 10.1164/rccm.201208-1460OC.


Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury.

Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay MA; National Heart, Blood, and Lung Institute Acute Respiratory Distress Syndrome Network.

Crit Care Med. 2011 Apr;39(4):711-7. doi: 10.1097/CCM.0b013e318207ec3c.


Ratio of angiopoietin-2 to angiopoietin-1 predicts mortality in acute lung injury induced by paraquat.

Choi JS, Kwak KA, Park MJ, Kim YH, Gil HW, Song HY, Hong SY.

Med Sci Monit. 2013 Jan 9;19:28-33.


Elevated Plasma Angiopoietin-2 Levels Are Associated With Fluid Overload, Organ Dysfunction, and Mortality in Human Septic Shock.

Fisher J, Douglas JJ, Linder A, Boyd JH, Walley KR, Russell JA.

Crit Care Med. 2016 Nov;44(11):2018-2027.


A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury.

Stapleton RD, Martin TR, Weiss NS, Crowley JJ, Gundel SJ, Nathens AB, Akhtar SR, Ruzinski JT, Caldwell E, Curtis JR, Heyland DK, Watkins TR, Parsons PE, Martin JM, Wurfel MM, Hallstrand TS, Sims KA, Neff MJ.

Crit Care Med. 2011 Jul;39(7):1655-62. doi: 10.1097/CCM.0b013e318218669d.


Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality.

van der Heijden M, Pickkers P, van Nieuw Amerongen GP, van Hinsbergh VW, Bouw MP, van der Hoeven JG, Groeneveld AB.

Intensive Care Med. 2009 Sep;35(9):1567-74. doi: 10.1007/s00134-009-1560-y. Epub 2009 Jun 24.


Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury.

Ware LB, Eisner MD, Thompson BT, Parsons PE, Matthay MA.

Am J Respir Crit Care Med. 2004 Oct 1;170(7):766-72. Epub 2004 Jun 16.


Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality.

Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A.

Am J Physiol Lung Cell Mol Physiol. 2016 Feb 1;310(3):L224-31. doi: 10.1152/ajplung.00336.2015. Epub 2015 Dec 11.


von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury.

Ware LB, Conner ER, Matthay MA.

Crit Care Med. 2001 Dec;29(12):2325-31. Review.


Plasma biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis*.

Terpstra ML, Aman J, van Nieuw Amerongen GP, Groeneveld AB.

Crit Care Med. 2014 Mar;42(3):691-700. doi: 10.1097/01.ccm.0000435669.60811.24. Review.


Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury.

Parsons PE, Eisner MD, Thompson BT, Matthay MA, Ancukiewicz M, Bernard GR, Wheeler AP; NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network.

Crit Care Med. 2005 Jan;33(1):1-6; discussion 230-2.


Plasma angiopoietin 2 concentrations are related to impaired lung function and organ failure in a clinical cohort receiving high-dose interleukin 2 therapy.

Gores KM, Delsing AS, Kraus SJ, Powers L, Vaena DA, Milhem MM, Monick M, Doerschug KC.

Shock. 2014 Aug;42(2):115-20. doi: 10.1097/SHK.0000000000000188.


Plasma granulocyte colony-stimulating factor levels correlate with clinical outcomes in patients with acute lung injury.

Suratt BT, Eisner MD, Calfee CS, Allard JB, Whittaker LA, Engelken DT, Petty JM, Trimarchi T, Gauthier L, Parsons PE; NHLBI Acute Respiratory Distress Syndrome Network.

Crit Care Med. 2009 Apr;37(4):1322-8. doi: 10.1097/CCM.0b013e31819c14fa.


Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury.

Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA; NHLBI ARDS Network.

Thorax. 2008 Dec;63(12):1083-9. doi: 10.1136/thx.2008.095588. Epub 2008 Jun 19.


Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome.

Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A.

Crit Care Med. 2017 May;45(5):858-866. doi: 10.1097/CCM.0000000000002370.


Prognostic significance of the angiopoietin-2/angiopoietin-1 and angiopoietin-1/Tie-2 ratios for early sepsis in an emergency department.

Fang Y, Li C, Shao R, Yu H, Zhang Q, Zhao L.

Crit Care. 2015 Oct 14;19:367. doi: 10.1186/s13054-015-1075-6.

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