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Items: 1 to 20 of 113

1.

The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.

Damgaard RB, Nachbur U, Yabal M, Wong WW, Fiil BK, Kastirr M, Rieser E, Rickard JA, Bankovacki A, Peschel C, Ruland J, Bekker-Jensen S, Mailand N, Kaufmann T, Strasser A, Walczak H, Silke J, Jost PJ, Gyrd-Hansen M.

Mol Cell. 2012 Jun 29;46(6):746-58. doi: 10.1016/j.molcel.2012.04.014. Epub 2012 May 17.

2.

Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.

Damgaard RB, Fiil BK, Speckmann C, Yabal M, zur Stadt U, Bekker-Jensen S, Jost PJ, Ehl S, Mailand N, Gyrd-Hansen M.

EMBO Mol Med. 2013 Aug;5(8):1278-95. doi: 10.1002/emmm.201303090. Epub 2013 Jul 1.

3.

Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease.

Chirieleison SM, Marsh RA, Kumar P, Rathkey JK, Dubyak GR, Abbott DW.

J Biol Chem. 2017 Jun 9;292(23):9666-9679. doi: 10.1074/jbc.M117.781500. Epub 2017 Apr 12.

PMID:
28404814
4.

XIAP mediates NOD signaling via interaction with RIP2.

Krieg A, Correa RG, Garrison JB, Le Negrate G, Welsh K, Huang Z, Knoefel WT, Reed JC.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14524-9. doi: 10.1073/pnas.0907131106. Epub 2009 Aug 10.

5.

A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling.

Tigno-Aranjuez JT, Bai X, Abbott DW.

Mol Cell Biol. 2013 Jan;33(1):146-58. doi: 10.1128/MCB.01049-12. Epub 2012 Oct 29.

6.

The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-κB activation by disturbing the interaction of XIAP with RIP2.

Condé C, Rambout X, Lebrun M, Lecat A, Di Valentin E, Dequiedt F, Piette J, Gloire G, Legrand S.

PLoS One. 2012;7(7):e41005. doi: 10.1371/journal.pone.0041005. Epub 2012 Jul 17.

7.

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.

Fiil BK, Damgaard RB, Wagner SA, Keusekotten K, Fritsch M, Bekker-Jensen S, Mailand N, Choudhary C, Komander D, Gyrd-Hansen M.

Mol Cell. 2013 Jun 27;50(6):818-830. doi: 10.1016/j.molcel.2013.06.004.

8.

NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.

Yang Y, Yin C, Pandey A, Abbott D, Sassetti C, Kelliher MA.

J Biol Chem. 2007 Dec 14;282(50):36223-9. Epub 2007 Oct 18.

9.

Characterization of Crohn disease in X-linked inhibitor of apoptosis-deficient male patients and female symptomatic carriers.

Aguilar C, Lenoir C, Lambert N, Bègue B, Brousse N, Canioni D, Berrebi D, Roy M, Gérart S, Chapel H, Schwerd T, Siproudhis L, Schäppi M, Al-Ahmari A, Mori M, Yamaide A, Galicier L, Neven B, Routes J, Uhlig HH, Koletzko S, Patel S, Kanegane H, Picard C, Fischer A, Bensussan NC, Ruemmele F, Hugot JP, Latour S.

J Allergy Clin Immunol. 2014 Nov;134(5):1131-41.e9. doi: 10.1016/j.jaci.2014.04.031. Epub 2014 Jun 15.

PMID:
24942515
10.

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.

Abbott DW, Yang Y, Hutti JE, Madhavarapu S, Kelliher MA, Cantley LC.

Mol Cell Biol. 2007 Sep;27(17):6012-25. Epub 2007 Jun 11.

11.

XIAP regulates cytosol-specific innate immunity to Listeria infection.

Bauler LD, Duckett CS, O'Riordan MX.

PLoS Pathog. 2008 Aug 29;4(8):e1000142. doi: 10.1371/journal.ppat.1000142.

12.

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

Bertrand MJ, Doiron K, Labbé K, Korneluk RG, Barker PA, Saleh M.

Immunity. 2009 Jun 19;30(6):789-801. doi: 10.1016/j.immuni.2009.04.011. Epub 2009 May 21.

13.

Convergence of innate immunity and insulin resistance as evidenced by increased nucleotide oligomerization domain (NOD) expression and signaling in monocytes from patients with type 2 diabetes.

Shiny A, Regin B, Balachandar V, Gokulakrishnan K, Mohan V, Babu S, Balasubramanyam M.

Cytokine. 2013 Nov;64(2):564-70. doi: 10.1016/j.cyto.2013.08.003. Epub 2013 Sep 6.

14.

Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2.

Ver Heul AM, Fowler CA, Ramaswamy S, Piper RC.

J Biol Chem. 2013 Mar 8;288(10):6890-902. doi: 10.1074/jbc.M112.413781. Epub 2013 Jan 8.

15.

Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation.

Bowman J, Rodgers MA, Shi M, Amatya R, Hostager B, Iwai K, Gao SJ, Jung JU.

MBio. 2015 Nov 17;6(6):e01777-15. doi: 10.1128/mBio.01777-15.

16.

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling.

Hrdinka M, Fiil BK, Zucca M, Leske D, Bagola K, Yabal M, Elliott PR, Damgaard RB, Komander D, Jost PJ, Gyrd-Hansen M.

Cell Rep. 2016 Mar 29;14(12):2846-58. doi: 10.1016/j.celrep.2016.02.062. Epub 2016 Mar 17.

17.

TAK1 is a central mediator of NOD2 signaling in epidermal cells.

Kim JY, Omori E, Matsumoto K, Núñez G, Ninomiya-Tsuji J.

J Biol Chem. 2008 Jan 4;283(1):137-44. Epub 2007 Oct 26.

18.

Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice.

Johansson ME, Zhang XY, Edfeldt K, Lundberg AM, Levin MC, Borén J, Li W, Yuan XM, Folkersen L, Eriksson P, Hedin U, Low H, Sviridov D, Rios FJ, Hansson GK, Yan ZQ.

Eur J Immunol. 2014 Oct;44(10):3081-92. doi: 10.1002/eji.201444755. Epub 2014 Aug 25.

19.

RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition.

Lipinski S, Grabe N, Jacobs G, Billmann-Born S, Till A, Häsler R, Aden K, Paulsen M, Arlt A, Kraemer L, Hagemann N, Erdmann KS, Schreiber S, Rosenstiel P.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21426-31. doi: 10.1073/pnas.1209673109. Epub 2012 Dec 3.

20.

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.

Tao M, Scacheri PC, Marinis JM, Harhaj EW, Matesic LE, Abbott DW.

Curr Biol. 2009 Aug 11;19(15):1255-63. doi: 10.1016/j.cub.2009.06.038. Epub 2009 Jul 9.

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