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Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.

Brown JE, Krodel M, Pazos M, Lai C, Prieto AL.

PLoS One. 2012;7(5):e36800. doi: 10.1371/journal.pone.0036800. Epub 2012 May 14.


Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons.

Prieto AL, O'Dell S, Varnum B, Lai C.

Neuroscience. 2007 Dec 5;150(2):319-34. Epub 2007 Sep 26.


Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival.

Ammoun S, Provenzano L, Zhou L, Barczyk M, Evans K, Hilton DA, Hafizi S, Hanemann CO.

Oncogene. 2014 Jan 16;33(3):336-46. doi: 10.1038/onc.2012.587. Epub 2013 Jan 14.


Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation.

Tsou WI, Nguyen KQ, Calarese DA, Garforth SJ, Antes AL, Smirnov SV, Almo SC, Birge RB, Kotenko SV.

J Biol Chem. 2014 Sep 12;289(37):25750-63. doi: 10.1074/jbc.M114.569020. Epub 2014 Jul 29.


Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.

Lew ED, Oh J, Burrola PG, Lax I, Zagórska A, Través PG, Schlessinger J, Lemke G.

Elife. 2014 Sep 29;3. doi: 10.7554/eLife.03385.


Autocrine role for Gas6 with Tyro3 and Axl in leiomyosarcomas.

el Sayadi H, Pissaloux D, Alberti L, Tabone-Eglinger S, Ranchere D, Decouvelaere AV, Tabone E, Ray-Coquard I, Caux C, Fayette J, Blay JY.

Target Oncol. 2013 Dec;8(4):261-9. doi: 10.1007/s11523-012-0249-2. Epub 2013 Jan 25.


The TAM-family receptor Mer mediates production of HGF through the RhoA-dependent pathway in response to apoptotic cells.

Park HJ, Baen JY, Lee YJ, Choi YH, Kang JL.

Mol Biol Cell. 2012 Aug;23(16):3254-65. doi: 10.1091/mbc.E12-01-0029. Epub 2012 Jun 27.


Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions.

Weinger JG, Omari KM, Marsden K, Raine CS, Shafit-Zagardo B.

Am J Pathol. 2009 Jul;175(1):283-93. doi: 10.2353/ajpath.2009.080807. Epub 2009 Jun 18.


Activation of TYRO3/AXL tyrosine kinase receptors in thyroid cancer.

Avilla E, Guarino V, Visciano C, Liotti F, Svelto M, Krishnamoorthy G, Franco R, Melillo RM.

Cancer Res. 2011 Mar 1;71(5):1792-804. doi: 10.1158/0008-5472.CAN-10-2186. Epub 2011 Feb 22.


Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor.

Sainaghi PP, Castello L, Bergamasco L, Galletti M, Bellosta P, Avanzi GC.

J Cell Physiol. 2005 Jul;204(1):36-44.


Gas6-induced tissue factor expression in endothelial cells is mediated through caveolin-1-enriched microdomains.

Laurance S, Aghourian MN, Jiva Lila Z, Lemarié CA, Blostein MD.

J Thromb Haemost. 2014;12(3):395-408. doi: 10.1111/jth.12481.


Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood.

Ekman C, Stenhoff J, Dahlbäck B.

J Thromb Haemost. 2010 Apr;8(4):838-44. doi: 10.1111/j.1538-7836.2010.03752.x. Epub 2010 Jan 17.


The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner.

Fraineau S, Monvoisin A, Clarhaut J, Talbot J, Simonneau C, Kanthou C, Kanse SM, Philippe M, Benzakour O.

Blood. 2012 Dec 13;120(25):5073-83. doi: 10.1182/blood-2012-05-429183. Epub 2012 Oct 12.


Tumor-associated macrophages promote oral cancer progression through activation of the Axl signaling pathway.

Lee CH, Liu SY, Chou KC, Yeh CT, Shiah SG, Huang RY, Cheng JC, Yen CY, Shieh YS.

Ann Surg Oncol. 2014 Mar;21(3):1031-7. doi: 10.1245/s10434-013-3400-0. Epub 2013 Nov 26.


Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.

Tai KY, Shieh YS, Lee CS, Shiah SG, Wu CW.

Oncogene. 2008 Jul 3;27(29):4044-55. doi: 10.1038/onc.2008.57. Epub 2008 Mar 17.


Evaluation of Tyro3 expression, Gas6-mediated Akt phosphorylation, and the impact of anti-Tyro3 antibodies in melanoma cell lines.

Demarest SJ, Gardner J, Vendel MC, Ailor E, Szak S, Huang F, Doern A, Tan X, Yang W, Grueneberg DA, Richards EJ, Endege WO, Harlow E, Koopman LA.

Biochemistry. 2013 May 7;52(18):3102-18. doi: 10.1021/bi301588c. Epub 2013 Apr 24.


AXL and MET crosstalk to promote gonadotropin releasing hormone (GnRH) neuronal cell migration and survival.

Salian-Mehta S, Xu M, Wierman ME.

Mol Cell Endocrinol. 2013 Jul 15;374(1-2):92-100. doi: 10.1016/j.mce.2013.04.018. Epub 2013 May 3.


NGF-induced Tyro3 and Axl function as survival factors for differentiating PC12 cells.

Zheng Y, Zhang L, Lu Q, Wang X, Yu F, Wang X, Lu Q.

Biochem Biophys Res Commun. 2009 Jan 16;378(3):371-5. doi: 10.1016/j.bbrc.2008.11.049. Epub 2008 Nov 24.


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