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Thrombomodulin is an ezrin-interacting protein that controls epithelial morphology and promotes collective cell migration.

Hsu YY, Shi GY, Kuo CH, Liu SL, Wu CM, Ma CY, Lin FY, Yang HY, Wu HL.

FASEB J. 2012 Aug;26(8):3440-52. doi: 10.1096/fj.12-204917. Epub 2012 May 16.


Thrombomodulin-mediated cell adhesion: involvement of its lectin-like domain.

Huang HC, Shi GY, Jiang SJ, Shi CS, Wu CM, Yang HY, Wu HL.

J Biol Chem. 2003 Nov 21;278(47):46750-9. Epub 2003 Sep 1.


Direct interaction of 14-3-3ζ with ezrin promotes cell migration by regulating the formation of membrane ruffle.

Chen M, Liu T, Xu L, Gao X, Liu X, Wang C, He Q, Zhang G, Liu L.

J Mol Biol. 2014 Sep 9;426(18):3118-33. doi: 10.1016/j.jmb.2014.06.021. Epub 2014 Jul 11.


DCC regulates cell adhesion in human colon cancer derived HT-29 cells and associates with ezrin.

Martín M, Simon-Assmann P, Kedinger M, Martin M, Mangeat P, Real FX, Fabre M.

Eur J Cell Biol. 2006 Aug;85(8):769-83. Epub 2006 Jun 8.


Properties of an ezrin mutant defective in F-actin binding.

Saleh HS, Merkel U, Geissler KJ, Sperka T, Sechi A, Breithaupt C, Morrison H.

J Mol Biol. 2009 Jan 30;385(4):1015-31. doi: 10.1016/j.jmb.2008.11.051. Epub 2008 Dec 3.


Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth.

Loughran G, Healy NC, Kiely PA, Huigsloot M, Kedersha NL, O'Connor R.

Mol Biol Cell. 2005 Apr;16(4):1811-22. Epub 2005 Jan 19.


Ezrin promotes actin assembly at the phagosome membrane and regulates phago-lysosomal fusion.

Marion S, Hoffmann E, Holzer D, Le Clainche C, Martin M, Sachse M, Ganeva I, Mangeat P, Griffiths G.

Traffic. 2011 Apr;12(4):421-37. doi: 10.1111/j.1600-0854.2011.01158.x. Epub 2011 Feb 8.


Thrombomodulin regulates keratinocyte differentiation and promotes wound healing.

Cheng TL, Wu YT, Lai CH, Kao YC, Kuo CH, Liu SL, Hsu YY, Chen PK, Cho CF, Wang KC, Lin WL, Chang BI, Chen CM, Weiler H, Shi GY, Wu HL.

J Invest Dermatol. 2013 Jun;133(6):1638-45. doi: 10.1038/jid.2013.8. Epub 2013 Jan 15.


The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways.

Conway EM, Van de Wouwer M, Pollefeyt S, Jurk K, Van Aken H, De Vriese A, Weitz JI, Weiler H, Hellings PW, Schaeffer P, Herbert JM, Collen D, Theilmeier G.

J Exp Med. 2002 Sep 2;196(5):565-77.


Organized migration of epithelial cells requires control of adhesion and protrusion through Rho kinase effectors.

Hopkins AM, Pineda AA, Winfree LM, Brown GT, Laukoetter MG, Nusrat A.

Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G806-17. Epub 2006 Nov 30.


The glomerular epithelial cell anti-adhesin podocalyxin associates with the actin cytoskeleton through interactions with ezrin.

Orlando RA, Takeda T, Zak B, Schmieder S, Benoit VM, McQuistan T, Furthmayr H, Farquhar MG.

J Am Soc Nephrol. 2001 Aug;12(8):1589-98.


Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells.

D'Angelo R, Aresta S, Blangy A, Del Maestro L, Louvard D, Arpin M.

Mol Biol Cell. 2007 Dec;18(12):4780-93. Epub 2007 Sep 19.


Characterization of the Ca2+ -regulated ezrin-S100P interaction and its role in tumor cell migration.

Austermann J, Nazmi AR, Müller-Tidow C, Gerke V.

J Biol Chem. 2008 Oct 24;283(43):29331-40. doi: 10.1074/jbc.M806145200. Epub 2008 Aug 25.


Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications.

Rasmussen M, Alexander RT, Darborg BV, Møbjerg N, Hoffmann EK, Kapus A, Pedersen SF.

Am J Physiol Cell Physiol. 2008 Jan;294(1):C197-212. Epub 2007 Oct 31.


Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- cells.

Favia M, Guerra L, Fanelli T, Cardone RA, Monterisi S, Di Sole F, Castellani S, Chen M, Seidler U, Reshkin SJ, Conese M, Casavola V.

Mol Biol Cell. 2010 Jan 1;21(1):73-86. doi: 10.1091/mbc.E09-03-0185. Epub 2009 Nov 4.


Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo.

Kioka N, Ito T, Yamashita H, Uekawa N, Umemoto T, Motoyoshi S, Imai H, Takahashi K, Watanabe H, Yamada M, Ueda K.

Exp Cell Res. 2010 Jun 10;316(10):1728-38. doi: 10.1016/j.yexcr.2010.03.019. Epub 2010 Mar 31.


Silence of ezrin modifies migration and actin cytoskeleton rearrangements and enhances chemosensitivity of lung cancer cells in vitro.

Chen QY, Xu W, Jiao DM, Wu LJ, Song J, Yan J, Shi JG.

Mol Cell Biochem. 2013 May;377(1-2):207-18. doi: 10.1007/s11010-013-1586-x. Epub 2013 Feb 22.


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