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The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.

Chan WY, Follows GA, Lacaud G, Pimanda JE, Landry JR, Kinston S, Knezevic K, Piltz S, Donaldson IJ, Gambardella L, Sablitzky F, Green AR, Kouskoff V, Göttgens B.

Blood. 2007 Mar 1;109(5):1908-16. Epub 2006 Oct 19.


The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1.

Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T.

Blood. 2002 Oct 1;100(7):2430-40.


Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.

Schlaeger TM, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P, Porcher C.

Mol Cell Biol. 2004 Sep;24(17):7491-502.


The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1.

Göttgens B, Broccardo C, Sanchez MJ, Deveaux S, Murphy G, Göthert JR, Kotsopoulou E, Kinston S, Delaney L, Piltz S, Barton LM, Knezevic K, Erber WN, Begley CG, Frampton J, Green AR.

Mol Cell Biol. 2004 Mar;24(5):1870-83.


Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.

Souroullas GP, Salmon JM, Sablitzky F, Curtis DJ, Goodell MA.

Cell Stem Cell. 2009 Feb 6;4(2):180-6. doi: 10.1016/j.stem.2009.01.001.


Opposing effects of the basic helix-loop-helix transcription factor SCL on erythroid and monocytic differentiation.

Hoang T, Paradis E, Brady G, Billia F, Nakahara K, Iscove NN, Kirsch IR.

Blood. 1996 Jan 1;87(1):102-11.


SCL: from the origin of hematopoiesis to stem cells and leukemia.

Lécuyer E, Hoang T.

Exp Hematol. 2004 Jan;32(1):11-24. Review.


Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.

Robb L, Lyons I, Li R, Hartley L, Köntgen F, Harvey RP, Metcalf D, Begley CG.

Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7075-9.


Gradient of E2A activity in B-cell development.

Herblot S, Aplan PD, Hoang T.

Mol Cell Biol. 2002 Feb;22(3):886-900.


Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development.

Schlaeger TM, Mikkola HK, Gekas C, Helgadottir HB, Orkin SH.

Blood. 2005 May 15;105(10):3871-4. Epub 2005 Jan 27.


The SCL/TAL1 gene: roles in normal and malignant haematopoiesis.

Robb L, Begley CG.

Bioessays. 1997 Jul;19(7):607-13. Review.


SCL is required for normal function of short-term repopulating hematopoietic stem cells.

Curtis DJ, Hall MA, Van Stekelenburg LJ, Robb L, Jane SM, Begley CG.

Blood. 2004 May 1;103(9):3342-8. Epub 2004 Jan 15.


Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer.

Sánchez MJ, Bockamp EO, Miller J, Gambardella L, Green AR.

Development. 2001 Dec;128(23):4815-27.


Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.

Porcher C, Liao EC, Fujiwara Y, Zon LI, Orkin SH.

Development. 1999 Oct;126(20):4603-15.


The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.

Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH.

Cell. 1996 Jul 12;86(1):47-57.


The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.

Robb L, Elwood NJ, Elefanty AG, Köntgen F, Li R, Barnett LD, Begley CG.

EMBO J. 1996 Aug 15;15(16):4123-9.

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