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Items: 1 to 20 of 62

1.

A genome-wide siRNA screen to identify modulators of insulin sensitivity and gluconeogenesis.

Yang R, Lacson RG, Castriota G, Zhang XD, Liu Y, Zhao W, Einstein M, Camargo LM, Qureshi S, Wong KK, Zhang BB, Ferrer M, Berger JP.

PLoS One. 2012;7(5):e36384. doi: 10.1371/journal.pone.0036384. Epub 2012 May 9.

2.

T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis.

Fukushima A, Loh K, Galic S, Fam B, Shields B, Wiede F, Tremblay ML, Watt MJ, Andrikopoulos S, Tiganis T.

Diabetes. 2010 Aug;59(8):1906-14. doi: 10.2337/db09-1365. Epub 2010 May 18.

3.

Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes.

Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G, Li P, Jadhar V, Vargeese C, Wang W, Bowman K, Zhang Y, Polisky B, Olefsky JM.

Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1137-46. doi: 10.1152/ajpendo.00158.2009. Epub 2009 Aug 25.

4.

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.

Samuel VT, Beddow SA, Iwasaki T, Zhang XM, Chu X, Still CD, Gerhard GS, Shulman GI.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12121-6. doi: 10.1073/pnas.0812547106. Epub 2009 Jul 8.

5.

Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network.

Tu Z, Argmann C, Wong KK, Mitnaul LJ, Edwards S, Sach IC, Zhu J, Schadt EE.

Genome Res. 2009 Jun;19(6):1057-67. doi: 10.1101/gr.087890.108. Epub 2009 Mar 4.

6.

Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice.

Sun Y, Liu S, Ferguson S, Wang L, Klepcyk P, Yun JS, Friedman JE.

J Biol Chem. 2002 Jun 28;277(26):23301-7. Epub 2002 Apr 18.

7.

Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP.

Kim YD, Park KG, Lee YS, Park YY, Kim DK, Nedumaran B, Jang WG, Cho WJ, Ha J, Lee IK, Lee CH, Choi HS.

Diabetes. 2008 Feb;57(2):306-14. Epub 2007 Oct 1.

8.
10.

Elevated Hepatic miR-22-3p Expression Impairs Gluconeogenesis by Silencing the Wnt-Responsive Transcription Factor Tcf7.

Kaur K, Vig S, Srivastava R, Mishra A, Singh VP, Srivastava AK, Datta M.

Diabetes. 2015 Nov;64(11):3659-69. doi: 10.2337/db14-1924. Epub 2015 Jul 20.

11.

Sodium arsenite induces orphan nuclear receptor SHP gene expression via AMP-activated protein kinase to inhibit gluconeogenic enzyme gene expression.

Chanda D, Kim SJ, Lee IK, Shong M, Choi HS.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E368-79. doi: 10.1152/ajpendo.00800.2007. Epub 2008 May 27.

12.

Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients.

Takamura T, Misu H, Matsuzawa-Nagata N, Sakurai M, Ota T, Shimizu A, Kurita S, Takeshita Y, Ando H, Honda M, Kaneko S.

Obesity (Silver Spring). 2008 Dec;16(12):2601-9. doi: 10.1038/oby.2008.419. Epub 2008 Oct 9.

13.

Negative regulators of insulin signaling revealed in a genome-wide functional screen.

Huang SM, Hancock MK, Pitman JL, Orth AP, Gekakis N.

PLoS One. 2009 Sep 3;4(9):e6871. doi: 10.1371/journal.pone.0006871.

14.

Novel concepts in insulin regulation of hepatic gluconeogenesis.

Barthel A, Schmoll D.

Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E685-92. Review.

15.

B-cell translocation gene-2 increases hepatic gluconeogenesis via induction of CREB.

Hwang SL, Kwon O, Lee SJ, Roh SS, Kim YD, Choi JH.

Biochem Biophys Res Commun. 2012 Nov 2;427(4):801-5. doi: 10.1016/j.bbrc.2012.09.146. Epub 2012 Oct 9.

PMID:
23058912
16.

High-carbohydrate diets induce hepatic insulin resistance to protect the liver from substrate overload.

Agius L.

Biochem Pharmacol. 2013 Feb 1;85(3):306-12. doi: 10.1016/j.bcp.2012.09.019. Epub 2012 Sep 26.

PMID:
23022226
17.
18.

Insulin resistance and the transcription of the glucose-6-phosphatase gene in newborn dogs.

Feng BC, Li J, Kliegman RM.

Biochem Mol Med. 1997 Apr;60(2):134-41.

PMID:
9169094
19.

Designing, optimizing, and implementing high-throughput siRNA genomic screening with glioma cells for the discovery of survival genes and novel drug targets.

Thaker NG, McDonald PR, Zhang F, Kitchens CA, Shun TY, Pollack IF, Lazo JS.

J Neurosci Methods. 2010 Jan 15;185(2):204-12. doi: 10.1016/j.jneumeth.2009.09.023. Epub 2009 Sep 25.

PMID:
19782703
20.

[Novel aspects in the mechanisms of steroid diabetes and the regulation of hepatic glucose production by insulin and steroids].

Barthel A, Scherbaum WA, Bornstein SR.

Med Klin (Munich). 2003 Apr 25;98(5):283-6. Review. German.

PMID:
12721674

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