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Items: 1 to 20 of 178

1.

Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages.

Kim B, Nguyen LA, Daddacha W, Hollenbaugh JA.

J Biol Chem. 2012 Jun 22;287(26):21570-4. doi: 10.1074/jbc.C112.374843. Epub 2012 May 14.

2.

Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply.

Dragin L, Nguyen LA, Lahouassa H, Sourisce A, Kim B, Ramirez BC, Margottin-Goguet F.

Retrovirology. 2013 Mar 11;10:30. doi: 10.1186/1742-4690-10-30.

3.

dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.

Hollenbaugh JA, Tao S, Lenzi GM, Ryu S, Kim DH, Diaz-Griffero F, Schinazi RF, Kim B.

Retrovirology. 2014 Aug 27;11:63. doi: 10.1186/s12977-014-0063-2.

4.

Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels.

Amie SM, Daly MB, Noble E, Schinazi RF, Bambara RA, Kim B.

J Biol Chem. 2013 Jul 12;288(28):20683-91. doi: 10.1074/jbc.M113.472159. Epub 2013 Jun 5.

5.

HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation.

DeLucia M, Mehrens J, Wu Y, Ahn J.

J Biol Chem. 2013 Jun 28;288(26):19116-26. doi: 10.1074/jbc.M113.469007. Epub 2013 May 15.

6.

Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly.

Wang H, Guo H, Su J, Rui Y, Zheng W, Gao W, Zhang W, Li Z, Liu G, Markham RB, Wei W, Yu XF.

J Virol. 2017 Apr 13;91(9). pii: e00225-17. doi: 10.1128/JVI.00225-17. Print 2017 May 1.

7.

Degradation of SAMHD1 by Vpx Is Independent of Uncoating.

Jáuregui P, Logue EC, Schultz ML, Fung S, Landau NR.

J Virol. 2015 May;89(10):5701-13. doi: 10.1128/JVI.03575-14. Epub 2015 Mar 11.

8.

SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.

Ballana E, Badia R, Terradas G, Torres-Torronteras J, Ruiz A, Pauls E, Riveira-Muñoz E, Clotet B, Martí R, Esté JA.

Antimicrob Agents Chemother. 2014 Aug;58(8):4804-13. doi: 10.1128/AAC.03145-14. Epub 2014 Jun 9.

9.

Host SAMHD1 protein promotes HIV-1 recombination in macrophages.

Nguyen LA, Kim DH, Daly MB, Allan KC, Kim B.

J Biol Chem. 2014 Jan 31;289(5):2489-96. doi: 10.1074/jbc.C113.522326. Epub 2013 Dec 18.

10.

Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.

Reinhard C, Bottinelli D, Kim B, Luban J.

Retrovirology. 2014 Feb 1;11:12. doi: 10.1186/1742-4690-11-12.

11.
12.

Mechanistic and Kinetic Differences between Reverse Transcriptases of Vpx Coding and Non-coding Lentiviruses.

Lenzi GM, Domaoal RA, Kim DH, Schinazi RF, Kim B.

J Biol Chem. 2015 Dec 11;290(50):30078-86. doi: 10.1074/jbc.M115.691576. Epub 2015 Oct 19.

13.

Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection.

Goujon C, Schaller T, Galão RP, Amie SM, Kim B, Olivieri K, Neil SJ, Malim MH.

Retrovirology. 2013 Feb 25;10:23. doi: 10.1186/1742-4690-10-23.

14.

HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.

Ahn J, Hao C, Yan J, DeLucia M, Mehrens J, Wang C, Gronenborn AM, Skowronski J.

J Biol Chem. 2012 Apr 6;287(15):12550-8. doi: 10.1074/jbc.M112.340711. Epub 2012 Feb 23.

15.

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac.

Brandariz-Nuñez A, Valle-Casuso JC, White TE, Laguette N, Benkirane M, Brojatsch J, Diaz-Griffero F.

Retrovirology. 2012 Jun 12;9:49. doi: 10.1186/1742-4690-9-49.

16.

Intracellular nucleotide levels and the control of retroviral infections.

Amie SM, Noble E, Kim B.

Virology. 2013 Feb 20;436(2):247-54. doi: 10.1016/j.virol.2012.11.010. Epub 2012 Dec 20. Review.

17.

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2729-2734. doi: 10.1073/pnas.1613635114. Epub 2017 Feb 22.

18.

A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest.

Wei W, Guo H, Han X, Liu X, Zhou X, Zhang W, Yu XF.

Cell Microbiol. 2012 Nov;14(11):1745-56. doi: 10.1111/j.1462-5822.2012.01835.x. Epub 2012 Aug 9.

PMID:
22776683
19.

Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1.

Fregoso OI, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M.

PLoS Pathog. 2013;9(7):e1003496. doi: 10.1371/journal.ppat.1003496. Epub 2013 Jul 18.

20.

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein.

Hrecka K, Hao C, Gierszewska M, Swanson SK, Kesik-Brodacka M, Srivastava S, Florens L, Washburn MP, Skowronski J.

Nature. 2011 Jun 29;474(7353):658-61. doi: 10.1038/nature10195.

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