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Items: 1 to 20 of 164

1.

Lack of T cells in Act1-deficient mice results in elevated IgM-specific autoantibodies but reduced lupus-like disease.

Johnson AC, Davison LM, Giltiay NV, Vareechon C, Li X, Jørgensen TN.

Eur J Immunol. 2012 Jul;42(7):1695-705. doi: 10.1002/eji.201142238.

2.

Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity.

Stohl W, Jacob N, Quinn WJ 3rd, Cancro MP, Gao H, Putterman C, Gao X, Pricop L, Koss MN.

J Immunol. 2008 Jul 1;181(1):833-41.

3.
4.

Altered BAFF-receptor signaling and additional modifier loci contribute to systemic autoimmunity in A/WySnJ mice.

Mayne CG, Nashold FE, Sasaki Y, Hayes CE.

Eur J Immunol. 2009 Feb;39(2):589-99. doi: 10.1002/eji.200838569.

5.

Spontaneous loss of tolerance of autoreactive B cells in Act1-deficient rheumatoid factor transgenic mice.

Giltiay NV, Lu Y, Cullen JL, Jørgensen TN, Shlomchik MJ, Li X.

J Immunol. 2013 Sep 1;191(5):2155-63. doi: 10.4049/jimmunol.1300152. Epub 2013 Jul 31.

6.

Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome.

Qian Y, Giltiay N, Xiao J, Wang Y, Tian J, Han S, Scott M, Carter R, Jorgensen TN, Li X.

Eur J Immunol. 2008 Aug;38(8):2219-28. doi: 10.1002/eji.200738113.

7.

The adaptor molecule Act1 regulates BAFF responsiveness and self-reactive B cell selection during transitional B cell maturation.

Giltiay NV, Lu Y, Allman D, Jørgensen TN, Li X.

J Immunol. 2010 Jul 1;185(1):99-109. doi: 10.4049/jimmunol.0903312. Epub 2010 Jun 11.

8.

B cells flying solo.

Groom J, Mackay F.

Immunol Cell Biol. 2008 Jan;86(1):40-6. doi: 10.1038/sj.icb.7100142. Review.

PMID:
18172443
9.

BAFF-driven autoimmunity requires CD19 expression.

Fairfax KA, Tsantikos E, Figgett WA, Vincent FB, Quah PS, LePage M, Hibbs ML, Mackay F.

J Autoimmun. 2015 Aug;62:1-10. doi: 10.1016/j.jaut.2015.06.001. Epub 2015 Jun 20.

PMID:
26103922
10.

B Cell and BAFF dependence of IFN-α-exaggerated disease in systemic lupus erythematosus-prone NZM 2328 mice.

Jacob N, Guo S, Mathian A, Koss MN, Gindea S, Putterman C, Jacob CO, Stohl W.

J Immunol. 2011 Apr 15;186(8):4984-93. doi: 10.4049/jimmunol.1000466. Epub 2011 Mar 7.

11.

Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.

Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA.

J Exp Med. 2010 Aug 2;207(8):1757-73. doi: 10.1084/jem.20100086. Epub 2010 Jul 12.

12.

Act1 modulates autoimmunity through its dual functions in CD40L/BAFF and IL-17 signaling.

Li X.

Cytokine. 2008 Feb;41(2):105-13. Epub 2007 Dec 3. Review.

PMID:
18061473
13.

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.

Weindel CG, Richey LJ, Bolland S, Mehta AJ, Kearney JF, Huber BT.

Autophagy. 2015;11(7):1010-24. doi: 10.1080/15548627.2015.1052206.

14.

TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma.

Batten M, Fletcher C, Ng LG, Groom J, Wheway J, Laâbi Y, Xin X, Schneider P, Tschopp J, Mackay CR, Mackay F.

J Immunol. 2004 Jan 15;172(2):812-22.

15.

Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice.

Coquery CM, Wade NS, Loo WM, Kinchen JM, Cox KM, Jiang C, Tung KS, Erickson LD.

PLoS One. 2014 Jul 10;9(7):e102284. doi: 10.1371/journal.pone.0102284. eCollection 2014.

16.

BAFF and MyD88 signals promote a lupuslike disease independent of T cells.

Groom JR, Fletcher CA, Walters SN, Grey ST, Watt SV, Sweet MJ, Smyth MJ, Mackay CR, Mackay F.

J Exp Med. 2007 Aug 6;204(8):1959-71. Epub 2007 Jul 30.

17.

Act1, a negative regulator in CD40- and BAFF-mediated B cell survival.

Qian Y, Qin J, Cui G, Naramura M, Snow EC, Ware CF, Fairchild RL, Omori SA, Rickert RC, Scott M, Kotzin BL, Li X.

Immunity. 2004 Oct;21(4):575-87.

18.

Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers.

Figgett WA, Deliyanti D, Fairfax KA, Quah PS, Wilkinson-Berka JL, Mackay F.

J Autoimmun. 2015 Jul;61:9-16. doi: 10.1016/j.jaut.2015.04.007. Epub 2015 May 29.

PMID:
26027434
19.

Expression of B-cell activating factor of the tumour necrosis factor family (BAFF) in T cells in active systemic lupus erythematosus: the role of BAFF in T cell-dependent B cell pathogenic autoantibody production.

Morimoto S, Nakano S, Watanabe T, Tamayama Y, Mitsuo A, Nakiri Y, Suzuki J, Nozawa K, Amano H, Tokano Y, Kobata T, Takasaki Y.

Rheumatology (Oxford). 2007 Jul;46(7):1083-6. Epub 2007 May 11.

PMID:
17500077
20.

Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black mice.

Pau E, Chang NH, Loh C, Lajoie G, Wither JE.

Clin Immunol. 2011 May;139(2):215-27. doi: 10.1016/j.clim.2011.02.005. Epub 2011 Mar 17.

PMID:
21414847

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