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Items: 1 to 20 of 246

1.

Ligand bias at metabotropic glutamate 1a receptors: molecular determinants that distinguish β-arrestin-mediated from G protein-mediated signaling.

Emery AC, DiRaddo JO, Miller E, Hathaway HA, Pshenichkin S, Takoudjou GR, Grajkowska E, Yasuda RP, Wolfe BB, Wroblewski JT.

Mol Pharmacol. 2012 Aug;82(2):291-301. doi: 10.1124/mol.112.078444. Epub 2012 May 14.

2.

The protective signaling of metabotropic glutamate receptor 1 Is mediated by sustained, beta-arrestin-1-dependent ERK phosphorylation.

Emery AC, Pshenichkin S, Takoudjou GR, Grajkowska E, Wolfe BB, Wroblewski JT.

J Biol Chem. 2010 Aug 20;285(34):26041-8. doi: 10.1074/jbc.M110.139899. Epub 2010 Jun 21.

3.

Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism.

Hathaway HA, Pshenichkin S, Grajkowska E, Gelb T, Emery AC, Wolfe BB, Wroblewski JT.

Neuropharmacology. 2015 Jun;93:199-208. doi: 10.1016/j.neuropharm.2015.02.007. Epub 2015 Feb 17.

4.

Atypical signaling of metabotropic glutamate receptor 1 in human melanoma cells.

Gelb T, Pshenichkin S, Hathaway HA, Grajkowska E, Dalley CB, Wolfe BB, Wroblewski JT.

Biochem Pharmacol. 2015 Nov 1;98(1):182-9. doi: 10.1016/j.bcp.2015.08.091. Epub 2015 Aug 17.

PMID:
26291396
6.

Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins.

Iacovelli L, Felicioni M, Nisticò R, Nicoletti F, De Blasi A.

Neuropharmacology. 2014 Feb;77:303-12. doi: 10.1016/j.neuropharm.2013.10.013. Epub 2013 Oct 19.

PMID:
24148810
7.

Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors.

Southern C, Cook JM, Neetoo-Isseljee Z, Taylor DL, Kettleborough CA, Merritt A, Bassoni DL, Raab WJ, Quinn E, Wehrman TS, Davenport AP, Brown AJ, Green A, Wigglesworth MJ, Rees S.

J Biomol Screen. 2013 Jun;18(5):599-609. doi: 10.1177/1087057113475480. Epub 2013 Feb 8.

PMID:
23396314
9.

Identification of G protein-biased agonists that fail to recruit β-arrestin or promote internalization of the D1 dopamine receptor.

Conroy JL, Free RB, Sibley DR.

ACS Chem Neurosci. 2015 Apr 15;6(4):681-92. doi: 10.1021/acschemneuro.5b00020. Epub 2015 Feb 20.

10.
11.

Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina.

Romano MR, Di Menna L, Scarselli P, Mascio G, Madonna M, Notartomaso S, Puliti A, Bruno V, Battaglia G, Nicoletti F.

Neurochem Res. 2016 Apr;41(4):924-32. doi: 10.1007/s11064-015-1775-y. Epub 2015 Dec 23.

PMID:
26700429
12.

beta-Arrestin recruitment assay for the identification of agonists of the sphingosine 1-phosphate receptor EDG1.

van Der Lee MM, Bras M, van Koppen CJ, Zaman GJ.

J Biomol Screen. 2008 Dec;13(10):986-98. doi: 10.1177/1087057108326144. Epub 2008 Nov 25.

PMID:
19036707
13.

Supersensitivity of human metabotropic glutamate 1a receptor signaling in L929sA cells.

Lavreysen H, Le Poul E, Van Gompel P, Dillen L, Leysen JE, Lesage AS.

Mol Pharmacol. 2002 May;61(5):1244-54.

14.

Analysis of functional selectivity through G protein-dependent and -independent signaling pathways at the adrenergic α(2C) receptor.

Kurko D, Kapui Z, Nagy J, Lendvai B, Kolok S.

Brain Res Bull. 2014 Aug;107:89-101. doi: 10.1016/j.brainresbull.2014.07.005. Epub 2014 Jul 29.

PMID:
25080296
15.

Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.

Ren XR, Reiter E, Ahn S, Kim J, Chen W, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1448-53. Epub 2005 Jan 25.

16.

Arrestin specificity for G protein-coupled receptors in human airway smooth muscle.

Penn RB, Pascual RM, Kim YM, Mundell SJ, Krymskaya VP, Panettieri RA Jr, Benovic JL.

J Biol Chem. 2001 Aug 31;276(35):32648-56. Epub 2001 Jun 20.

18.

beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.

Tohgo A, Pierce KL, Choy EW, Lefkowitz RJ, Luttrell LM.

J Biol Chem. 2002 Mar 15;277(11):9429-36. Epub 2002 Jan 2.

20.

β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.

Mancini AD, Bertrand G, Vivot K, Carpentier É, Tremblay C, Ghislain J, Bouvier M, Poitout V.

J Biol Chem. 2015 Aug 21;290(34):21131-40. doi: 10.1074/jbc.M115.644450. Epub 2015 Jul 8.

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