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Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.

Shearn CT, Fritz KS, Reigan P, Petersen DR.

Biochemistry. 2011 May 17;50(19):3984-96. doi: 10.1021/bi200029w.


Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in human hepatoma cells.

Ma W, Li C, Yin S, Liu J, Gao C, Lin Z, Huang R, Huang J, Li Z.

Free Radic Biol Med. 2015 Dec;89:1003-13. doi: 10.1016/j.freeradbiomed.2015.09.020.


Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes.

Shearn CT, Smathers RL, Stewart BJ, Fritz KS, Galligan JJ, Hail N Jr, Petersen DR.

Mol Pharmacol. 2011 Jun;79(6):941-52. doi: 10.1124/mol.110.069534.


Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.

Shearn CT, Backos DS, Orlicky DJ, Smathers-McCullough RL, Petersen DR.

J Biol Chem. 2014 May 30;289(22):15449-62. doi: 10.1074/jbc.M113.543942.


4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway.

Chaudhary P, Sharma R, Sahu M, Vishwanatha JK, Awasthi S, Awasthi YC.

J Biol Chem. 2013 Jul 12;288(28):20532-46. doi: 10.1074/jbc.M113.467662.


Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells.

Vatsyayan R, Chaudhary P, Sharma A, Sharma R, Rao Lelsani PC, Awasthi S, Awasthi YC.

Exp Eye Res. 2011 Feb;92(2):147-54. doi: 10.1016/j.exer.2010.11.010.


Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation.

Singh R, Wang Y, Schattenberg JM, Xiang Y, Czaja MJ.

Am J Physiol Gastrointest Liver Physiol. 2009 Nov;297(5):G907-17.


The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway.

Kim DE, Kim B, Shin HS, Kwon HJ, Park ES.

Exp Cell Res. 2014 Oct 1;327(2):264-75. doi: 10.1016/j.yexcr.2014.07.037.


BRaf and MEK inhibitors differentially regulate cell fate and microenvironment in human hepatocellular carcinoma.

Breunig C, Mueller BJ, Umansky L, Wahl K, Hoffmann K, Lehner F, Manns MP, Bantel H, Falk CS.

Clin Cancer Res. 2014 May 1;20(9):2410-23. doi: 10.1158/1078-0432.CCR-13-1635.


Sulfatase 2 protects hepatocellular carcinoma cells against apoptosis induced by the PI3K inhibitor LY294002 and ERK and JNK kinase inhibitors.

Lai JP, Sandhu DS, Yu C, Moser CD, Hu C, Shire AM, Aderca I, Murphy LM, Adjei AA, Sanderson S, Roberts LR.

Liver Int. 2010 Nov;30(10):1522-8. doi: 10.1111/j.1478-3231.2010.02336.x.


PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways.

Gedaly R, Angulo P, Hundley J, Daily MF, Chen C, Koch A, Evers BM.

Anticancer Res. 2010 Dec;30(12):4951-8.


Hydrogen peroxide activates focal adhesion kinase and c-Src by a phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell monolayers.

Basuroy S, Dunagan M, Sheth P, Seth A, Rao RK.

Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G186-95. doi: 10.1152/ajpgi.00368.2009.


Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells.

Nguyen Ho-Bouldoires TH, Clapéron A, Mergey M, Wendum D, Desbois-Mouthon C, Tahraoui S, Fartoux L, Chettouh H, Merabtene F, Scatton O, Gaestel M, Praz F, Housset C, Fouassier L.

Free Radic Biol Med. 2015 Dec;89:34-46. doi: 10.1016/j.freeradbiomed.2015.07.011.


[Metformin induces apoptosis in hepatocellular carcinoma Huh-7 cells in vitro and its mechanism].

Lin F, Yan W, Wen T, Wu GY.

Zhonghua Zhong Liu Za Zhi. 2013 Oct;35(10):742-6. Chinese.


Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells.

Dozza B, Smith MA, Perry G, Tabaton M, Strocchi P.

J Neurochem. 2004 Jun;89(5):1224-32.


FoxO proteins' nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells.

Shukla S, Rizvi F, Raisuddin S, Kakkar P.

Free Radic Biol Med. 2014 Nov;76:185-99. doi: 10.1016/j.freeradbiomed.2014.07.039.


PTEN, Akt, and GSK3beta signalling in rat primary cortical neuronal cultures following tumor necrosis factor-alpha and trans-4-hydroxy-2-nonenal treatments.

Rickle A, Behbahani H, Ankarcrona M, Winblad B, Cowburn RF.

J Neurosci Res. 2006 Aug 15;84(3):596-605.


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