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Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity.

Pollard KM, Hultman P, Toomey CB, Cauvi DM, Hoffman HM, Hamel JC, Kono DH.

J Autoimmun. 2012 Dec;39(4):323-31. doi: 10.1016/j.jaut.2012.04.003. Epub 2012 May 10.


Costimulation requirements of induced murine systemic autoimmune disease.

Pollard KM, Arnush M, Hultman P, Kono DH.

J Immunol. 2004 Nov 1;173(9):5880-7.


Decay-accelerating factor 1 (Daf1) deficiency exacerbates xenobiotic-induced autoimmunity.

Toomey CB, Cauvi DM, Song WC, Pollard KM.

Immunology. 2010 Sep;131(1):99-106. doi: 10.1111/j.1365-2567.2010.03279.x. Epub 2010 Apr 12.


Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity.

Toomey CB, Cauvi DM, Hamel JC, Ramirez AE, Pollard KM.

Toxicol Sci. 2014 Dec;142(2):339-49. doi: 10.1093/toxsci/kfu189. Epub 2014 Sep 18.


The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance.

Kono DH, Balomenos D, Pearson DL, Park MS, Hildebrandt B, Hultman P, Pollard KM.

J Immunol. 1998 Jul 1;161(1):234-40.


β2-microglobulin is required for the full expression of xenobiotic-induced systemic autoimmunity.

Pollard KM, Hultman P, Toomey CB, Cauvi DM, Kono DH.

J Immunotoxicol. 2011 Jul-Sep;8(3):228-37. doi: 10.3109/1547691X.2011.583614. Erratum in: J Immunotoxicol. 2011 Oct-Dec;8(4):398. Konoc, Dwight H [corrected to Kono, Dwight H].


Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.

Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA.

J Exp Med. 2010 Aug 2;207(8):1757-73. doi: 10.1084/jem.20100086. Epub 2010 Jul 12.


Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway.

Afanasyeva M, Wang Y, Kaya Z, Stafford EA, Dohmen KM, Sadighi Akha AA, Rose NR.

Circulation. 2001 Dec 18;104(25):3145-51.


From the Cover: Interplay Between IFN-γ and IL-6 Impacts the Inflammatory Response and Expression of Interferon-Regulated Genes in Environmental-Induced Autoimmunity.

Cauvi DM, Cauvi G, Toomey CB, Jacquinet E, Pollard KM.

Toxicol Sci. 2017 Jul 1;158(1):227-239. doi: 10.1093/toxsci/kfx083.


IFN-γ is reciprocally involved in the concurrent development of organ-specific autoimmunity in the liver and stomach.

Iwamoto S, Kido M, Aoki N, Nishiura H, Maruoka R, Ikeda A, Okazaki T, Chiba T, Watanabe N.

Autoimmunity. 2012 Mar;45(2):186-98. doi: 10.3109/08916934.2011.616559. Epub 2011 Oct 13.


CD83 expression in CD4+ T cells modulates inflammation and autoimmunity.

Reinwald S, Wiethe C, Westendorf AM, Breloer M, Probst-Kepper M, Fleischer B, Steinkasserer A, Buer J, Hansen W.

J Immunol. 2008 May 1;180(9):5890-7.


Immunology and genetics of induced systemic autoimmunity.

Pollard KM, Hultman P, Kono DH.

Autoimmun Rev. 2005 Jun;4(5):282-8. Epub 2005 Jan 11. Review.


Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis.

Kawata K, Tsuda M, Yang GX, Zhang W, Tanaka H, Tsuneyama K, Leung P, He XS, Knechtle S, Ansari AA, Coppel RL, Gershwin ME.

PLoS One. 2013 Sep 10;8(9):e74225. doi: 10.1371/journal.pone.0074225. eCollection 2013.


Amelioration of mercury-induced autoimmunity by 4-1BB.

Vinay DS, Kim JD, Kwon BS.

J Immunol. 2006 Oct 15;177(8):5708-17.


Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways.

Lawless VA, Zhang S, Ozes ON, Bruns HA, Oldham I, Hoey T, Grusby MJ, Kaplan MH.

J Immunol. 2000 Dec 15;165(12):6803-8.


Using single-gene deletions to identify checkpoints in the progression of systemic autoimmunity.

Pollard KM, Hultman P, Kono DH.

Ann N Y Acad Sci. 2003 Apr;987:236-9. Review.


Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity.

Havarinasab S, Pollard KM, Hultman P.

Clin Exp Immunol. 2009 Mar;155(3):567-76. doi: 10.1111/j.1365-2249.2008.03831.x. Epub 2008 Dec 5.

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