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Items: 1 to 20 of 110

1.

Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular dysplasia in the adult mouse.

Choi EJ, Walker EJ, Shen F, Oh SP, Arthur HM, Young WL, Su H.

Cerebrovasc Dis. 2012;33(6):540-7. doi: 10.1159/000337762. Epub 2012 May 9.

2.

Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice.

Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL, Su H.

Transl Stroke Res. 2016 Dec;7(6):488-496. Epub 2016 Jun 29.

3.

Arteriovenous malformation in the adult mouse brain resembling the human disease.

Walker EJ, Su H, Shen F, Choi EJ, Oh SP, Chen G, Lawton MT, Kim H, Chen Y, Chen W, Young WL.

Ann Neurol. 2011 Jun;69(6):954-62. doi: 10.1002/ana.22348. Epub 2011 Mar 17.

4.

De novo cerebrovascular malformation in the adult mouse after endothelial Alk1 deletion and angiogenic stimulation.

Chen W, Sun Z, Han Z, Jun K, Camus M, Wankhede M, Mao L, Arnold T, Young WL, Su H.

Stroke. 2014 Mar;45(3):900-2. doi: 10.1161/STROKEAHA.113.003655. Epub 2014 Jan 23.

5.

VEGF Induces More Severe Cerebrovascular Dysplasia in Endoglin than in Alk1 Mice.

Hao Q, Zhu Y, Su H, Shen F, Yang GY, Kim H, Young WL.

Transl Stroke Res. 2010 Sep 1;1(3):197-201.

6.

Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia.

Choi EJ, Chen W, Jun K, Arthur HM, Young WL, Su H.

PLoS One. 2014 Feb 10;9(2):e88511. doi: 10.1371/journal.pone.0088511. eCollection 2014.

7.

Endoglin deficiency in bone marrow is sufficient to cause cerebrovascular dysplasia in the adult mouse after vascular endothelial growth factor stimulation.

Choi EJ, Walker EJ, Degos V, Jun K, Kuo R, Pile-Spellman J, Su H, Young WL.

Stroke. 2013 Mar;44(3):795-8. doi: 10.1161/STROKEAHA.112.671974. Epub 2013 Jan 10.

8.

Reduced mural cell coverage and impaired vessel integrity after angiogenic stimulation in the Alk1-deficient brain.

Chen W, Guo Y, Walker EJ, Shen F, Jun K, Oh SP, Degos V, Lawton MT, Tihan T, Davalos D, Akassoglou K, Nelson J, Pile-Spellman J, Su H, Young WL.

Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):305-10. doi: 10.1161/ATVBAHA.112.300485. Epub 2012 Dec 13.

9.

Endoglin and activin receptor-like kinase 1 heterozygous mice have a distinct pulmonary and hepatic angiogenic profile and response to anti-VEGF treatment.

Ardelean DS, Jerkic M, Yin M, Peter M, Ngan B, Kerbel RS, Foster FS, Letarte M.

Angiogenesis. 2014 Jan;17(1):129-46. doi: 10.1007/s10456-013-9383-4. Epub 2013 Sep 24.

PMID:
24061911
10.

Common and distinctive pathogenetic features of arteriovenous malformations in hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 animal models--brief report.

Garrido-Martin EM, Nguyen HL, Cunningham TA, Choe SW, Jiang Z, Arthur HM, Lee YJ, Oh SP.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2232-6. doi: 10.1161/ATVBAHA.114.303984. Epub 2014 Jul 31.

11.

Bevacizumab attenuates VEGF-induced angiogenesis and vascular malformations in the adult mouse brain.

Walker EJ, Su H, Shen F, Degos V, Amend G, Jun K, Young WL.

Stroke. 2012 Jul;43(7):1925-30. doi: 10.1161/STROKEAHA.111.647982. Epub 2012 May 8. Erratum in: Stroke. 2013 Mar;44(3):e21. Amend, Gregory [added].

12.

Vascular endothelial growth factor induces abnormal microvasculature in the endoglin heterozygous mouse brain.

Xu B, Wu YQ, Huey M, Arthur HM, Marchuk DA, Hashimoto T, Young WL, Yang GY.

J Cereb Blood Flow Metab. 2004 Feb;24(2):237-44.

PMID:
14747750
13.

Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation.

Hao Q, Su H, Marchuk DA, Rola R, Wang Y, Liu W, Young WL, Yang GY.

Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2250-6. doi: 10.1152/ajpheart.00083.2008. Epub 2008 Oct 3.

14.

Induction of brain arteriovenous malformation in the adult mouse.

Chen W, Young WL, Su H.

Methods Mol Biol. 2014;1135:309-16. doi: 10.1007/978-1-4939-0320-7_25. Erratum in: Methods Mol Biol. 2014;1135:E1.

15.

Enhanced responses to angiogenic cues underlie the pathogenesis of hereditary hemorrhagic telangiectasia 2.

Choi EJ, Kim YH, Choe SW, Tak YG, Garrido-Martin EM, Chang M, Lee YJ, Oh SP.

PLoS One. 2013 May 10;8(5):e63138. doi: 10.1371/journal.pone.0063138. Print 2013.

16.

Immunosuppressor FK506 increases endoglin and activin receptor-like kinase 1 expression and modulates transforming growth factor-β1 signaling in endothelial cells.

Albiñana V, Sanz-Rodríguez F, Recio-Poveda L, Bernabéu C, Botella LM.

Mol Pharmacol. 2011 May;79(5):833-43. doi: 10.1124/mol.110.067447. Epub 2011 Feb 10.

17.

Polymorphisms in transforming growth factor-beta-related genes ALK1 and ENG are associated with sporadic brain arteriovenous malformations.

Pawlikowska L, Tran MN, Achrol AS, Ha C, Burchard E, Choudhry S, Zaroff J, Lawton MT, Castro R, McCulloch CE, Marchuk D, Kwok PY, Young WL; UCSF BAVM Study Project.

Stroke. 2005 Oct;36(10):2278-80. Epub 2005 Sep 22.

18.

Hereditary hemorrhagic telangiectasia, a vascular dysplasia affecting the TGF-beta signaling pathway.

Fernández-L A, Sanz-Rodriguez F, Blanco FJ, Bernabéu C, Botella LM.

Clin Med Res. 2006 Mar;4(1):66-78. Review.

19.

Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity.

Zhu W, Shen F, Mao L, Zhan L, Kang S, Sun Z, Nelson J, Zhang R, Zou D, McDougall CM, Lawton MT, Vu TH, Wu Z, Scaria A, Colosi P, Forsayeth J, Su H.

Stroke. 2017 May;48(5):1420-1423. doi: 10.1161/STROKEAHA.116.015713. Epub 2017 Mar 21.

20.

Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH.

Mahmoud M, Borthwick GM, Hislop AA, Arthur HM.

Lab Invest. 2009 Jan;89(1):15-25. doi: 10.1038/labinvest.2008.112. Epub 2008 Nov 17.

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