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Items: 1 to 20 of 140

1.

The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH).

Skaddan MB, Zhang L, Johnson DS, Zhu A, Zasadny KR, Coelho RV, Kuszpit K, Currier G, Fan KH, Beck EM, Chen L, Drozda SE, Balan G, Niphakis M, Cravatt BF, Ahn K, Bocan T, Villalobos A.

Nucl Med Biol. 2012 Oct;39(7):1058-67. doi: 10.1016/j.nucmedbio.2012.03.011. Epub 2012 May 8.

2.

Synthesis and preclinical evaluation of [11C-carbonyl]PF-04457845 for neuroimaging of fatty acid amide hydrolase.

Hicks JW, Parkes J, Sadovski O, Tong J, Houle S, Vasdev N, Wilson AA.

Nucl Med Biol. 2013 Aug;40(6):740-6. doi: 10.1016/j.nucmedbio.2013.04.008. Epub 2013 May 31.

3.

[11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography.

Wilson AA, Garcia A, Parkes J, Houle S, Tong J, Vasdev N.

Nucl Med Biol. 2011 Feb;38(2):247-53. doi: 10.1016/j.nucmedbio.2010.08.001.

PMID:
21315280
4.

Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain.

Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, Nomanbhoy TK, Weerapana E, Johnson DS, Cravatt BF.

J Pharmacol Exp Ther. 2011 Jul;338(1):114-24. doi: 10.1124/jpet.111.180257. Epub 2011 Apr 19.

5.

Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase.

Sadovski O, Hicks JW, Parkes J, Raymond R, Nobrega J, Houle S, Cipriano M, Fowler CJ, Vasdev N, Wilson AA.

Bioorg Med Chem. 2013 Jul 15;21(14):4351-7. doi: 10.1016/j.bmc.2013.04.077. Epub 2013 May 7.

6.

PET imaging of fatty acid amide hydrolase in the brain: synthesis and biological evaluation of an 11C-labelled URB597 analogue.

Wyffels L, Muccioli GG, Kapanda CN, Labar G, De Bruyne S, De Vos F, Lambert DM.

Nucl Med Biol. 2010 Jul;37(5):665-75. doi: 10.1016/j.nucmedbio.2010.03.009. Epub 2010 May 6.

PMID:
20610171
7.

Synthesis and preclinical evaluation of [¹⁸F]FCHC for neuroimaging of fatty acid amide hydrolase.

Shoup TM, Bonab AA, Wilson AA, Vasdev N.

Mol Imaging Biol. 2015 Apr;17(2):257-63. doi: 10.1007/s11307-014-0789-1.

PMID:
25273322
8.

Blocking of fatty acid amide hydrolase activity with PF-04457845 in human brain: a positron emission tomography study with the novel radioligand [(11)C]CURB.

Boileau I, Rusjan PM, Williams B, Mansouri E, Mizrahi R, De Luca V, Johnson DS, Wilson AA, Houle S, Kish SJ, Tong J.

J Cereb Blood Flow Metab. 2015 Nov;35(11):1827-35. doi: 10.1038/jcbfm.2015.133. Epub 2015 Jun 17.

9.

Development of [(11)C]MFTC for PET imaging of fatty acid amide hydrolase in rat and monkey brains.

Kumata K, Yui J, Hatori A, Maeda J, Xie L, Ogawa M, Yamasaki T, Nagai Y, Shimoda Y, Fujinaga M, Kawamura K, Zhang MR.

ACS Chem Neurosci. 2015 Feb 18;6(2):339-46. doi: 10.1021/cn500269g. Epub 2014 Nov 26.

PMID:
25398123
10.

4-(3-((5-(2-[18F]Fluoroethoxy)pyridine-2-yl)oxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide.

Leung K.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2012 Oct 20 [updated 2013 Feb 7].

11.

Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([¹¹C]MPPO) Based on α-Ketoheterocyclic Scaffold.

Wang L, Yui J, Wang Q, Zhang Y, Mori W, Shimoda Y, Fujinaga M, Kumata K, Yamasaki T, Hatori A, Rotstein BH, Collier TL, Ran C, Vasdev N, Zhang MR, Liang SH.

ACS Chem Neurosci. 2016 Jan 20;7(1):109-18. doi: 10.1021/acschemneuro.5b00248. Epub 2015 Nov 17.

12.

Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography.

Wilson AA, Hicks JW, Sadovski O, Parkes J, Tong J, Houle S, Fowler CJ, Vasdev N.

J Med Chem. 2013 Jan 10;56(1):201-9. doi: 10.1021/jm301492y. Epub 2012 Dec 19.

13.

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.

Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, Lund ET, Nugent RA, Nomanbhoy TK, Alexander JP, Cravatt BF.

Biochemistry. 2007 Nov 13;46(45):13019-30. Epub 2007 Oct 19.

PMID:
17949010
14.

N-(3,4-Dimethylisoxazol-5-yl)piperazine-4-[4-(2-fluoro-4-[(11)C]methylphenyl)thiazol-2-yl]-1-carboxamide: A promising positron emission tomography ligand for fatty acid amide hydrolase.

Shimoda Y, Fujinaga M, Hatori A, Yui J, Zhang Y, Nengaki N, Kurihara Y, Yamasaki T, Xie L, Kumata K, Ishii H, Zhang MR.

Bioorg Med Chem. 2016 Feb 15;24(4):627-34. doi: 10.1016/j.bmc.2015.12.026. Epub 2015 Dec 15.

PMID:
26740152
15.

PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates.

Rotstein BH, Wey HY, Shoup TM, Wilson AA, Liang SH, Hooker JM, Vasdev N.

Mol Pharm. 2014 Nov 3;11(11):3832-8. doi: 10.1021/mp500316h. Epub 2014 Jul 16.

16.

The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice.

Booker L, Kinsey SG, Abdullah RA, Blankman JL, Long JZ, Ezzili C, Boger DL, Cravatt BF, Lichtman AH.

Br J Pharmacol. 2012 Apr;165(8):2485-96. doi: 10.1111/j.1476-5381.2011.01445.x.

17.

Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.

Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, Swaney S, Van Becelaere K, Stevens RC, Cravatt BF.

Chem Biol. 2009 Apr 24;16(4):411-20. doi: 10.1016/j.chembiol.2009.02.013.

18.

Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [11C]CURB.

Boileau I, Mansouri E, Williams B, Le Foll B, Rusjan P, Mizrahi R, Tyndale RF, Huestis MA, Payer DE, Wilson AA, Houle S, Kish SJ, Tong J.

Biol Psychiatry. 2016 Nov 1;80(9):691-701. doi: 10.1016/j.biopsych.2016.04.012. Epub 2016 Apr 25.

19.

Synthesis and evaluation of a new vesamicol analog o-[(11)C]methyl-trans-decalinvesamicol as a PET ligand for the vesicular acetylcholine transporter.

Kitamura Y, Kozaka T, Miwa D, Uno I, Azim MA, Ogawa K, Taki J, Kinuya S, Shiba K.

Ann Nucl Med. 2016 Feb;30(2):122-9. doi: 10.1007/s12149-015-1039-6. Epub 2015 Nov 25.

PMID:
26608176
20.

Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides.

Fichna J, Sałaga M, Stuart J, Saur D, Sobczak M, Zatorski H, Timmermans JP, Bradshaw HB, Ahn K, Storr MA.

Neurogastroenterol Motil. 2014 Apr;26(4):470-81. doi: 10.1111/nmo.12272. Epub 2013 Dec 3.

PMID:
24460851

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