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Can a tool that automates insulin titration be a key to diabetes management?

Bergenstal RM, Bashan E, McShane M, Johnson M, Hodish I.

Diabetes Technol Ther. 2012 Aug;14(8):675-82. doi: 10.1089/dia.2011.0303. Epub 2012 May 8.


Frequent insulin dosage adjustments based on glucose readings alone are sufficient for a safe and effective therapy.

Bashan E, Hodish I.

J Diabetes Complications. 2012 May-Jun;26(3):230-6. doi: 10.1016/j.jdiacomp.2012.03.012. Epub 2012 Apr 20.


Are glucose readings sufficient to adjust insulin dosage?

Bashan E, Herman WH, Hodish I.

Diabetes Technol Ther. 2011 Jan;13(1):85-92. doi: 10.1089/dia.2010.0112.


Humalog Mix 25 in patients with type 2 diabetes which do not achieve acceptable glycemic control with oral agents: results from a phase III, randomized, parallel study.

Tîrgovişte CI, Străchinariu R, Farcaşiu E, Milicevic Z, Teodorescu G.

Rom J Intern Med. 2003;41(2):153-62.


Addition of neutral protamine lispro insulin or insulin glargine to oral type 2 diabetes regimens for patients with suboptimal glycemic control: a randomized trial.

Esposito K, Ciotola M, Maiorino MI, Gualdiero R, Schisano B, Ceriello A, Beneduce F, Feola G, Giugliano D.

Ann Intern Med. 2008 Oct 21;149(8):531-9.


The effort required to achieve and maintain optimal glycemic control.

Rosenthal ES, Bashan E, Herman WH, Hodish I.

J Diabetes Complications. 2011 Sep-Oct;25(5):283-8. doi: 10.1016/j.jdiacomp.2011.01.002. Epub 2011 Mar 1.


Effect of Continuous Glucose Monitoring on Glycemic Control in Adults With Type 1 Diabetes Using Insulin Injections: The DIAMOND Randomized Clinical Trial.

Beck RW, Riddlesworth T, Ruedy K, Ahmann A, Bergenstal R, Haller S, Kollman C, Kruger D, McGill JB, Polonsky W, Toschi E, Wolpert H, Price D; DIAMOND Study Group.

JAMA. 2017 Jan 24;317(4):371-378. doi: 10.1001/jama.2016.19975.


Patient-directed titration for achieving glycaemic goals using a once-daily basal insulin analogue: an assessment of two different fasting plasma glucose targets - the TITRATE study.

Blonde L, Merilainen M, Karwe V, Raskin P; TITRATE Study Group.

Diabetes Obes Metab. 2009 Jun;11(6):623-31. doi: 10.1111/j.1463-1326.2009.01060.x.


An exploratory trial of basal and prandial insulin initiation and titration for type 2 diabetes in primary care with adjunct retrospective continuous glucose monitoring: INITIATION study.

Blackberry ID, Furler JS, Ginnivan LE, Manski-Nankervis JA, Jenkins A, Cohen N, Best JD, Young D, Liew D, Ward G, O'Neal DN.

Diabetes Res Clin Pract. 2014 Nov;106(2):247-55. doi: 10.1016/j.diabres.2014.08.011. Epub 2014 Sep 8.


Use of an insulin bolus advisor improves glycemic control in multiple daily insulin injection (MDI) therapy patients with suboptimal glycemic control: first results from the ABACUS trial.

Ziegler R, Cavan DA, Cranston I, Barnard K, Ryder J, Vogel C, Parkin CG, Koehler W, Vesper I, Petersen B, Schweitzer MA, Wagner RS.

Diabetes Care. 2013 Nov;36(11):3613-9. doi: 10.2337/dc13-0251. Epub 2013 Jul 30.


Use of an insulin bolus advisor facilitates earlier and more frequent changes in insulin therapy parameters in suboptimally controlled patients with diabetes treated with multiple daily insulin injection therapy: results of the ABACUS trial.

Cavan DA, Ziegler R, Cranston I, Barnard K, Ryder J, Vogel C, Parkin CG, Koehler W, Vesper I, Petersen B, Schweitzer MA, Wagner RS.

Diabetes Technol Ther. 2014 May;16(5):310-6. doi: 10.1089/dia.2013.0280. Epub 2014 Apr 9.


Glycemic Variability Is Associated with Frequency of Blood Glucose Testing and Bolus: Post Hoc Analysis Results from the ProAct Study.

Pfützner A, Weissmann J, Mougiakakou S, Daskalaki E, Weis N, Ziegler R.

Diabetes Technol Ther. 2015 Jun;17(6):392-7. doi: 10.1089/dia.2014.0278. Epub 2015 Mar 3.


Improved glycemic control in intensively treated adult subjects with type 1 diabetes using insulin guidance software.

Garg SK, Bookout TR, McFann KK, Kelly WC, Beatson C, Ellis SL, Gutin RS, Gottlieb PA.

Diabetes Technol Ther. 2008 Oct;10(5):369-75. doi: 10.1089/dia.2007.0303.

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