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Items: 1 to 20 of 93

1.

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors.

Ojo KK, Pfander C, Mueller NR, Burstroem C, Larson ET, Bryan CM, Fox AM, Reid MC, Johnson SM, Murphy RC, Kennedy M, Mann H, Leibly DJ, Hewitt SN, Verlinde CL, Kappe S, Merritt EA, Maly DJ, Billker O, Van Voorhis WC.

J Clin Invest. 2012 Jun;122(6):2301-5. doi: 10.1172/JCI61822. Epub 2012 May 8.

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3.

Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission.

Kern S, Agarwal S, Huber K, Gehring AP, Strödke B, Wirth CC, Brügl T, Abodo LO, Dandekar T, Doerig C, Fischer R, Tobin AB, Alam MM, Bracher F, Pradel G.

PLoS One. 2014 Sep 4;9(9):e105732. doi: 10.1371/journal.pone.0105732. eCollection 2014.

4.

Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.

Vidadala RS, Ojo KK, Johnson SM, Zhang Z, Leonard SE, Mitra A, Choi R, Reid MC, Keyloun KR, Fox AM, Kennedy M, Silver-Brace T, Hume JC, Kappe S, Verlinde CL, Fan E, Merritt EA, Van Voorhis WC, Maly DJ.

Eur J Med Chem. 2014 Mar 3;74:562-73. doi: 10.1016/j.ejmech.2013.12.048. Epub 2014 Jan 11.

5.

Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions.

Da DF, Churcher TS, Yerbanga RS, Yaméogo B, Sangaré I, Ouedraogo JB, Sinden RE, Blagborough AM, Cohuet A.

Exp Parasitol. 2015 Feb;149:74-83. doi: 10.1016/j.exppara.2014.12.010. Epub 2014 Dec 23.

6.

A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.

Ojo KK, Eastman RT, Vidadala R, Zhang Z, Rivas KL, Choi R, Lutz JD, Reid MC, Fox AM, Hulverson MA, Kennedy M, Isoherranen N, Kim LM, Comess KM, Kempf DJ, Verlinde CL, Su XZ, Kappe SH, Maly DJ, Fan E, Van Voorhis WC.

J Infect Dis. 2014 Jan 15;209(2):275-84. doi: 10.1093/infdis/jit522. Epub 2013 Oct 10.

7.

An essential role for the Plasmodium Nek-2 Nima-related protein kinase in the sexual development of malaria parasites.

Reininger L, Tewari R, Fennell C, Holland Z, Goldring D, Ranford-Cartwright L, Billker O, Doerig C.

J Biol Chem. 2009 Jul 31;284(31):20858-68. doi: 10.1074/jbc.M109.017988. Epub 2009 Jun 2.

8.

A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.

Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, Wu Y, Su XZ.

Antimicrob Agents Chemother. 2013 Jan;57(1):425-35. doi: 10.1128/AAC.00920-12. Epub 2012 Nov 5.

9.

Characterization of a Plasmodium berghei sexual stage antigen PbPH as a new candidate for malaria transmission-blocking vaccine.

Kou X, Zheng W, Du F, Liu F, Wang M, Fan Q, Cui L, Luo E, Cao Y.

Parasit Vectors. 2016 Apr 2;9:190. doi: 10.1186/s13071-016-1459-8. Erratum in: Parasit Vectors. 2017 Feb 16;10 (1):84.

10.

Carboxypeptidases B of Anopheles gambiae as targets for a Plasmodium falciparum transmission-blocking vaccine.

Lavazec C, Boudin C, Lacroix R, Bonnet S, Diop A, Thiberge S, Boisson B, Tahar R, Bourgouin C.

Infect Immun. 2007 Apr;75(4):1635-42. Epub 2007 Feb 5.

11.

Transmission blocking activity of a standardized neem (Azadirachta indica) seed extract on the rodent malaria parasite Plasmodium berghei in its vector Anopheles stephensi.

Lucantoni L, Yerbanga RS, Lupidi G, Pasqualini L, Esposito F, Habluetzel A.

Malar J. 2010 Mar 2;9:66. doi: 10.1186/1475-2875-9-66.

12.

The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission.

Tewari R, Straschil U, Bateman A, Böhme U, Cherevach I, Gong P, Pain A, Billker O.

Cell Host Microbe. 2010 Oct 21;8(4):377-87. doi: 10.1016/j.chom.2010.09.006.

13.

Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination.

Bousema T, Drakeley C.

Clin Microbiol Rev. 2011 Apr;24(2):377-410. doi: 10.1128/CMR.00051-10. Review.

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Plasmodium falciparum malaria disease manifestations in humans and transmission to Anopheles gambiae: a field study in Western Kenya.

Gouagna LC, Ferguson HM, Okech BA, Killeen GF, Kabiru EW, Beier JC, Githure JI, Yan G.

Parasitology. 2004 Mar;128(Pt 3):235-43.

PMID:
15074873
16.

Transmission blocking activity of Azadirachta indica and Guiera senegalensis extracts on the sporogonic development of Plasmodium falciparum field isolates in Anopheles coluzzii mosquitoes.

Yerbanga RS, Lucantoni L, Ouédraogo RK, Da DF, Yao FA, Yaméogo KB, Churcher TS, Lupidi G, Taglialatela-Scafati O, Gouagna LC, Cohuet A, Christophides GK, Ouédraogo JB, Habluetzel A.

Parasit Vectors. 2014 Apr 15;7:185. doi: 10.1186/1756-3305-7-185.

17.

Malaria: targeting parasite and host cell kinomes.

Doerig C, Abdi A, Bland N, Eschenlauer S, Dorin-Semblat D, Fennell C, Halbert J, Holland Z, Nivez MP, Semblat JP, Sicard A, Reininger L.

Biochim Biophys Acta. 2010 Mar;1804(3):604-12. doi: 10.1016/j.bbapap.2009.10.009. Epub 2009 Oct 17. Review.

PMID:
19840874
18.

Malaria parasite-synthesized heme is essential in the mosquito and liver stages and complements host heme in the blood stages of infection.

Nagaraj VA, Sundaram B, Varadarajan NM, Subramani PA, Kalappa DM, Ghosh SK, Padmanaban G.

PLoS Pathog. 2013;9(8):e1003522. doi: 10.1371/journal.ppat.1003522. Epub 2013 Aug 1.

19.

Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission.

Bobenchik AM, Witola WH, Augagneur Y, Nic Lochlainn L, Garg A, Pachikara N, Choi JY, Zhao YO, Usmani-Brown S, Lee A, Adjalley SH, Samanta S, Fidock DA, Voelker DR, Fikrig E, Ben Mamoun C.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18262-7. doi: 10.1073/pnas.1313965110. Epub 2013 Oct 21.

20.

Nasal immunization with a malaria transmission-blocking vaccine candidate, Pfs25, induces complete protective immunity in mice against field isolates of Plasmodium falciparum.

Arakawa T, Komesu A, Otsuki H, Sattabongkot J, Udomsangpetch R, Matsumoto Y, Tsuji N, Wu Y, Torii M, Tsuboi T.

Infect Immun. 2005 Nov;73(11):7375-80.

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