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TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression.

Duvvuri U, Shiwarski DJ, Xiao D, Bertrand C, Huang X, Edinger RS, Rock JR, Harfe BD, Henson BJ, Kunzelmann K, Schreiber R, Seethala RS, Egloff AM, Chen X, Lui VW, Grandis JR, Gollin SM.

Cancer Res. 2012 Jul 1;72(13):3270-81. doi: 10.1158/0008-5472.CAN-12-0475-T. Epub 2012 May 7.


Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.

Cohen EE, Lingen MW, Zhu B, Zhu H, Straza MW, Pierce C, Martin LE, Rosner MR.

Cancer Res. 2006 Jun 15;66(12):6296-303.


TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation.

Dixit R, Kemp C, Kulich S, Seethala R, Chiosea S, Ling S, Ha PK, Duvvuri U.

Sci Rep. 2015 Nov 13;5:16657. doi: 10.1038/srep16657.


To "grow" or "go": TMEM16A expression as a switch between tumor growth and metastasis in SCCHN.

Shiwarski DJ, Shao C, Bill A, Kim J, Xiao D, Bertrand CA, Seethala RS, Sano D, Myers JN, Ha P, Grandis J, Gaither LA, Puthenveedu MA, Duvvuri U.

Clin Cancer Res. 2014 Sep 1;20(17):4673-88. doi: 10.1158/1078-0432.CCR-14-0363. Epub 2014 Jun 11.


ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.

Bill A, Gutierrez A, Kulkarni S, Kemp C, Bonenfant D, Voshol H, Duvvuri U, Gaither LA.

Oncotarget. 2015 Apr 20;6(11):9173-88.


Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells.

Sui Y, Sun M, Wu F, Yang L, Di W, Zhang G, Zhong L, Ma Z, Zheng J, Fang X, Ma T.

PLoS One. 2014 Dec 26;9(12):e115443. doi: 10.1371/journal.pone.0115443. eCollection 2014.


Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments.

Albanell J, Codony-Servat J, Rojo F, Del Campo JM, Sauleda S, Anido J, Raspall G, Giralt J, Roselló J, Nicholson RI, Mendelsohn J, Baselga J.

Cancer Res. 2001 Sep 1;61(17):6500-10.


ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK).

Aguirre-Ghiso JA, Estrada Y, Liu D, Ossowski L.

Cancer Res. 2003 Apr 1;63(7):1684-95.


Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.

Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, Rebhan M, Raman P, Guy CT, Wetzel K, George E, Popa MO, Lilley S, Choudhury H, Gosling M, Wang L, Fitzgerald S, Borawski J, Baffoe J, Labow M, Gaither LA, Bentires-Alj M.

Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E1026-34. doi: 10.1073/pnas.1217072110. Epub 2013 Feb 19.


Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor.

Lui VW, Thomas SM, Zhang Q, Wentzel AL, Siegfried JM, Li JY, Grandis JR.

Oncogene. 2003 Sep 18;22(40):6183-93.


Rap1 mediates galanin receptor 2-induced proliferation and survival in squamous cell carcinoma.

Banerjee R, Henson BS, Russo N, Tsodikov A, D'Silva NJ.

Cell Signal. 2011 Jul;23(7):1110-8. doi: 10.1016/j.cellsig.2011.02.002. Epub 2011 Feb 21.


TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2.

Kulkarni S, Bill A, Godse NR, Khan NI, Kass JI, Steehler K, Kemp C, Davis K, Bertrand CA, Vyas AR, Holt DE, Grandis JR, Gaither LA, Duvvuri U.

Genes Chromosomes Cancer. 2017 Jun;56(6):460-471. doi: 10.1002/gcc.22450. Epub 2017 Apr 3.


HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma.

Lai JP, Chien J, Strome SE, Staub J, Montoya DP, Greene EL, Smith DI, Roberts LR, Shridhar V.

Oncogene. 2004 Feb 19;23(7):1439-47.


Inhibition of Calcium-Activated Chloride Channel ANO1/TMEM16A Suppresses Tumor Growth and Invasion in Human Lung Cancer.

Jia L, Liu W, Guan L, Lu M, Wang K.

PLoS One. 2015 Aug 25;10(8):e0136584. doi: 10.1371/journal.pone.0136584. eCollection 2015.


Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis.

Ruiz C, Martins JR, Rudin F, Schneider S, Dietsche T, Fischer CA, Tornillo L, Terracciano LM, Schreiber R, Bubendorf L, Kunzelmann K.

PLoS One. 2012;7(8):e43265. doi: 10.1371/journal.pone.0043265. Epub 2012 Aug 17.


SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells.

Zhang Q, Thomas SM, Xi S, Smithgall TE, Siegfried JM, Kamens J, Gooding WE, Grandis JR.

Cancer Res. 2004 Sep 1;64(17):6166-73.


Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2.

Chung LY, Tang SJ, Sun GH, Chou TY, Yeh TS, Yu SL, Sun KH.

Clin Cancer Res. 2012 Aug 1;18(15):4037-47. Epub 2012 Jun 13.

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