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Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice.

Matrisciano F, Tueting P, Dalal I, Kadriu B, Grayson DR, Davis JM, Nicoletti F, Guidotti A.

Neuropharmacology. 2013 May;68:184-94. doi: 10.1016/j.neuropharm.2012.04.013. Epub 2012 Apr 28.


Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia.

Dong E, Agis-Balboa RC, Simonini MV, Grayson DR, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12578-83. Epub 2005 Aug 19.


The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes.

Kundakovic M, Chen Y, Guidotti A, Grayson DR.

Mol Pharmacol. 2009 Feb;75(2):342-54. doi: 10.1124/mol.108.051763. Epub 2008 Nov 24.


Brain-derived neurotrophic factor epigenetic modifications associated with schizophrenia-like phenotype induced by prenatal stress in mice.

Dong E, Dzitoyeva SG, Matrisciano F, Tueting P, Grayson DR, Guidotti A.

Biol Psychiatry. 2015 Mar 15;77(6):589-96. doi: 10.1016/j.biopsych.2014.08.012. Epub 2014 Aug 27.


DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures.

Noh JS, Sharma RP, Veldic M, Salvacion AA, Jia X, Chen Y, Costa E, Guidotti A, Grayson DR.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1749-54. Epub 2005 Jan 25.


Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.

Matrisciano F, Tueting P, Maccari S, Nicoletti F, Guidotti A.

Neuropsychopharmacology. 2012 Mar;37(4):929-38. doi: 10.1038/npp.2011.274. Epub 2011 Nov 16.


Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice.

Tremolizzo L, Doueiri MS, Dong E, Grayson DR, Davis J, Pinna G, Tueting P, Rodriguez-Menendez V, Costa E, Guidotti A.

Biol Psychiatry. 2005 Mar 1;57(5):500-9.


DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains.

Veldic M, Caruncho HJ, Liu WS, Davis J, Satta R, Grayson DR, Guidotti A, Costa E.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):348-53. Epub 2003 Dec 18.


DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.

Dong E, Ruzicka WB, Grayson DR, Guidotti A.

Schizophr Res. 2015 Sep;167(1-3):35-41. doi: 10.1016/j.schres.2014.10.030. Epub 2014 Dec 2.


Antipsychotic subtypes can be characterized by differences in their ability to modify GABAergic promoter methylation.

Dong E, Grayson DR, Guidotti A, Costa E.

Epigenomics. 2009 Oct;1(1):201-11. doi: 10.2217/epi.09.2.


DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes.

Kundakovic M, Chen Y, Costa E, Grayson DR.

Mol Pharmacol. 2007 Mar;71(3):644-53. Epub 2006 Oct 25.


GABAergic dysfunction in mGlu7 receptor-deficient mice as reflected by decreased levels of glutamic acid decarboxylase 65 and 67kDa and increased reelin proteins in the hippocampus.

Wierońska JM, Brański P, Siwek A, Dybala M, Nowak G, Pilc A.

Brain Res. 2010 Jun 2;1334:12-24. doi: 10.1016/j.brainres.2010.03.078. Epub 2010 Mar 29.


The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia.

Grayson DR, Chen Y, Costa E, Dong E, Guidotti A, Kundakovic M, Sharma RP.

Pharmacol Ther. 2006 Jul;111(1):272-86. Epub 2006 Mar 30. Review.


A stereological comparison of GAD67 and reelin expression in the hippocampal stratum oriens of offspring from two mouse models of maternal inflammation during pregnancy.

Harvey L, Boksa P.

Neuropharmacology. 2012 Mar;62(4):1767-76. doi: 10.1016/j.neuropharm.2011.11.022. Epub 2011 Dec 9.


Corticosterone treatment during adolescence induces down-regulation of reelin and NMDA receptor subunit GLUN2C expression only in male mice: implications for schizophrenia.

Buret L, van den Buuse M.

Int J Neuropsychopharmacol. 2014 Aug;17(8):1221-32. doi: 10.1017/S1461145714000121. Epub 2014 Feb 21.


Effects of melatonin on prenatal dexamethasone-induced epigenetic alterations in hippocampal morphology and reelin and glutamic acid decarboxylase 67 levels.

Lui CC, Hsu MH, Kuo HC, Chen CC, Sheen JM, Yu HR, Tiao MM, Tain YL, Chang KA, Huang LT.

Dev Neurosci. 2015;37(2):105-14. doi: 10.1159/000368768. Epub 2015 Feb 25.


Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats.

Palacios-García I, Lara-Vásquez A, Montiel JF, Díaz-Véliz GF, Sepúlveda H, Utreras E, Montecino M, González-Billault C, Aboitiz F.

PLoS One. 2015 Feb 13;10(2):e0117680. doi: 10.1371/journal.pone.0117680. eCollection 2015.


Single and combined effects of prenatal immune activation and peripubertal stress on parvalbumin and reelin expression in the hippocampal formation.

Giovanoli S, Weber L, Meyer U.

Brain Behav Immun. 2014 Aug;40:48-54. doi: 10.1016/j.bbi.2014.04.005. Epub 2014 May 22.


Schizophrenia and reelin: a model based on prenatal stress to study epigenetics, brain development and behavior.

Negrón-Oyarzo I, Lara-Vásquez A, Palacios-García I, Fuentealba P, Aboitiz F.

Biol Res. 2016 Mar 11;49:16. doi: 10.1186/s40659-016-0076-5. Review.


Behavioral and molecular neuroepigenetic alterations in prenatally stressed mice: relevance for the study of chromatin remodeling properties of antipsychotic drugs.

Dong E, Tueting P, Matrisciano F, Grayson DR, Guidotti A.

Transl Psychiatry. 2016 Jan 12;6:e711. doi: 10.1038/tp.2015.191.

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