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Items: 1 to 20 of 328


Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia.

Murphy KT, Chee A, Trieu J, Naim T, Lynch GS.

Dis Model Mech. 2012 Jul;5(4):533-45. doi: 10.1242/dmm.008839. Epub 2012 Mar 22.


Inhibition of the renin-angiotensin system improves physiological outcomes in mice with mild or severe cancer cachexia.

Murphy KT, Chee A, Trieu J, Naim T, Lynch GS.

Int J Cancer. 2013 Sep 1;133(5):1234-46. doi: 10.1002/ijc.28128. Epub 2013 Mar 16.


Muscle-specific E3 ubiquitin ligases are involved in muscle atrophy of cancer cachexia: an in vitro and in vivo study.

Yuan L, Han J, Meng Q, Xi Q, Zhuang Q, Jiang Y, Han Y, Zhang B, Fang J, Wu G.

Oncol Rep. 2015 May;33(5):2261-8. doi: 10.3892/or.2015.3845. Epub 2015 Mar 9.


Diaphragm and ventilatory dysfunction during cancer cachexia.

Roberts BM, Ahn B, Smuder AJ, Al-Rajhi M, Gill LC, Beharry AW, Powers SK, Fuller DD, Ferreira LF, Judge AR.

FASEB J. 2013 Jul;27(7):2600-10. doi: 10.1096/fj.12-222844. Epub 2013 Mar 20.


Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia.

Silva KA, Dong J, Dong Y, Dong Y, Schor N, Tweardy DJ, Zhang L, Mitch WE.

J Biol Chem. 2015 Apr 24;290(17):11177-87. doi: 10.1074/jbc.M115.641514. Epub 2015 Mar 18.


Comparison of the anticatabolic effects of leucine and Ca-β-hydroxy-β-methylbutyrate in experimental models of cancer cachexia.

Mirza KA, Pereira SL, Voss AC, Tisdale MJ.

Nutrition. 2014 Jul-Aug;30(7-8):807-13. doi: 10.1016/j.nut.2013.11.012. Epub 2013 Dec 4.


Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.

Reed SA, Sandesara PB, Senf SM, Judge AR.

FASEB J. 2012 Mar;26(3):987-1000. doi: 10.1096/fj.11-189977. Epub 2011 Nov 18.


Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice.

Murphy KT, Chee A, Gleeson BG, Naim T, Swiderski K, Koopman R, Lynch GS.

Am J Physiol Regul Integr Comp Physiol. 2011 Sep;301(3):R716-26. doi: 10.1152/ajpregu.00121.2011. Epub 2011 Jun 15.


Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBPβ-regulated atrogin1 expression in cancer cachexia.

Sun R, Zhang S, Hu W, Lu X, Lou N, Yang Z, Chen S, Zhang X, Yang H.

Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C101-15. doi: 10.1152/ajpcell.00344.2015. Epub 2016 Apr 27.


Tumor inoculation site affects the development of cancer cachexia and muscle wasting.

Matsuyama T, Ishikawa T, Okayama T, Oka K, Adachi S, Mizushima K, Kimura R, Okajima M, Sakai H, Sakamoto N, Katada K, Kamada K, Uchiyama K, Handa O, Takagi T, Kokura S, Naito Y, Itoh Y.

Int J Cancer. 2015 Dec 1;137(11):2558-65. doi: 10.1002/ijc.29620. Epub 2015 Jun 10.


Mitochondrial and sarcoplasmic reticulum abnormalities in cancer cachexia: altered energetic efficiency?

Fontes-Oliveira CC, Busquets S, Toledo M, Penna F, Paz Aylwin M, Sirisi S, Silva AP, Orpí M, García A, Sette A, Inês Genovese M, Olivan M, López-Soriano FJ, Argilés JM.

Biochim Biophys Acta. 2013 Mar;1830(3):2770-8.


Physiological characterization of a mouse model of cachexia in colorectal liver metastases.

Murphy KT, Struk A, Malcontenti-Wilson C, Christophi C, Lynch GS.

Am J Physiol Regul Integr Comp Physiol. 2013 May 15;304(10):R854-64. doi: 10.1152/ajpregu.00057.2013. Epub 2013 Mar 13.


Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia.

Tseng YC, Kulp SK, Lai IL, Hsu EC, He WA, Frankhouser DE, Yan PS, Mo X, Bloomston M, Lesinski GB, Marcucci G, Guttridge DC, Bekaii-Saab T, Chen CS.

J Natl Cancer Inst. 2015 Oct 12;107(12):djv274. doi: 10.1093/jnci/djv274. Print 2015 Dec.


Myocardial dysfunction in an animal model of cancer cachexia.

Xu H, Crawford D, Hutchinson KR, Youtz DJ, Lucchesi PA, Velten M, McCarthy DO, Wold LE.

Life Sci. 2011 Feb 28;88(9-10):406-10. doi: 10.1016/j.lfs.2010.12.010. Epub 2010 Dec 14.


Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice.

Winbanks CE, Murphy KT, Bernardo BC, Qian H, Liu Y, Sepulveda PV, Beyer C, Hagg A, Thomson RE, Chen JL, Walton KL, Loveland KL, McMullen JR, Rodgers BD, Harrison CA, Lynch GS, Gregorevic P.

Sci Transl Med. 2016 Jul 20;8(348):348ra98. doi: 10.1126/scitranslmed.aac4976.


Citrus unshiu peel extract alleviates cancer-induced weight loss in mice bearing CT-26 adenocarcinoma.

Kim A, Im M, Gu MJ, Ma JY.

Sci Rep. 2016 Apr 11;6:24214. doi: 10.1038/srep24214.


Role of PARP activity in lung cancer-induced cachexia: Effects on muscle oxidative stress, proteolysis, anabolic markers, and phenotype.

Chacon-Cabrera A, Mateu-Jimenez M, Langohr K, Fermoselle C, García-Arumí E, Andreu AL, Yelamos J, Barreiro E.

J Cell Physiol. 2017 Dec;232(12):3744-3761. doi: 10.1002/jcp.25851. Epub 2017 Apr 27.


Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia.

Ham DJ, Murphy KT, Chee A, Lynch GS, Koopman R.

Clin Nutr. 2014 Jun;33(3):448-58. doi: 10.1016/j.clnu.2013.06.013. Epub 2013 Jun 26.


Cancer cachexia decreases specific force and accelerates fatigue in limb muscle.

Roberts BM, Frye GS, Ahn B, Ferreira LF, Judge AR.

Biochem Biophys Res Commun. 2013 Jun 7;435(3):488-92. doi: 10.1016/j.bbrc.2013.05.018. Epub 2013 May 11.

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