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Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer.

Stolzenburg S, Rots MG, Beltran AS, Rivenbark AG, Yuan X, Qian H, Strahl BD, Blancafort P.

Nucleic Acids Res. 2012 Aug;40(14):6725-40.


Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer.

Stolzenburg S, Beltran AS, Swift-Scanlan T, Rivenbark AG, Rashwan R, Blancafort P.

Oncogene. 2015 Oct;34(43):5427-35. doi: 10.1038/onc.2014.470.


Engineered zinc-finger transcription factors activate OCT4 (POU5F1), SOX2, KLF4, c-MYC (MYC) and miR302/367.

Ji Q, Fischer AL, Brown CR, Eastlund ER, Dvash T, Zhong B, Gerber MA, Lyons I, Knight SW, Kreader CA.

Nucleic Acids Res. 2014 Jun;42(10):6158-67. doi: 10.1093/nar/gku243.


The emerging role of SOX2 in cell proliferation and survival and its crosstalk with oncogenic signaling in lung cancer.

Chou YT, Lee CC, Hsiao SH, Lin SE, Lin SC, Chung CH, Chung CH, Kao YR, Wang YH, Chen CT, Wei YH, Wu CW.

Stem Cells. 2013 Dec;31(12):2607-19. doi: 10.1002/stem.1518.


EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer.

Singh S, Trevino J, Bora-Singhal N, Coppola D, Haura E, Altiok S, Chellappan SP.

Mol Cancer. 2012 Sep 25;11:73. doi: 10.1186/1476-4598-11-73.


Identification of two novel phenotypically distinct breast cancer cell subsets based on Sox2 transcription activity.

Wu F, Zhang J, Wang P, Ye X, Jung K, Bone KM, Pearson JD, Ingham RJ, McMullen TP, Ma Y, Lai R.

Cell Signal. 2012 Nov;24(11):1989-98. doi: 10.1016/j.cellsig.2012.07.008.


Sox2 is an androgen receptor-repressed gene that promotes castration-resistant prostate cancer.

Kregel S, Kiriluk KJ, Rosen AM, Cai Y, Reyes EE, Otto KB, Tom W, Paner GP, Szmulewitz RZ, Vander Griend DJ.

PLoS One. 2013;8(1):e53701. doi: 10.1371/journal.pone.0053701.


Epigenetic reprogramming of cancer cells via targeted DNA methylation.

Rivenbark AG, Stolzenburg S, Beltran AS, Yuan X, Rots MG, Strahl BD, Blancafort P.

Epigenetics. 2012 Apr;7(4):350-60. doi: 10.4161/epi.19507.


Emerging role of long non-coding RNA SOX2OT in SOX2 regulation in breast cancer.

Askarian-Amiri ME, Seyfoddin V, Smart CE, Wang J, Kim JE, Hansji H, Baguley BC, Finlay GJ, Leung EY.

PLoS One. 2014 Jul 9;9(7):e102140. doi: 10.1371/journal.pone.0102140.


Role of SOX2 in the etiology of embryonal carcinoma, based on analysis of the NCCIT and NT2 cell lines.

Eini R, Stoop H, Gillis AJ, Biermann K, Dorssers LC, Looijenga LH.

PLoS One. 2014 Jan 3;9(1):e83585. doi: 10.1371/journal.pone.0083585.


MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis.

Otsubo T, Akiyama Y, Hashimoto Y, Shimada S, Goto K, Yuasa Y.

PLoS One. 2011 Jan 27;6(1):e16617. doi: 10.1371/journal.pone.0016617.


Novel Function of Lysine Methyltransferase G9a in the Regulation of Sox2 Protein Stability.

Lee JY, Lee SH, Heo SH, Kim KS, Kim C, Kim DK, Ko JJ, Park KS.

PLoS One. 2015 Oct 22;10(10):e0141118. doi: 10.1371/journal.pone.0141118.


Reprogramming of non-genomic estrogen signaling by the stemness factor SOX2 enhances the tumor-initiating capacity of breast cancer cells.

Vazquez-Martin A, Cufí S, López-Bonet E, Corominas-Faja B, Cuyàs E, Vellon L, Iglesias JM, Leis O, Martín AG, Menendez JA.

Cell Cycle. 2013 Nov 15;12(22):3471-7. doi: 10.4161/cc.26692.


YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells.

Bora-Singhal N, Nguyen J, Schaal C, Perumal D, Singh S, Coppola D, Chellappan S.

Stem Cells. 2015 Jun;33(6):1705-18. doi: 10.1002/stem.1993.


Simultaneous siRNA targeting of Src and downstream signaling molecules inhibit tumor formation and metastasis of a human model breast cancer cell line.

Bjorge JD, Pang AS, Funnell M, Chen KY, Diaz R, Magliocco AM, Fujita DJ.

PLoS One. 2011 Apr 26;6(4):e19309. doi: 10.1371/journal.pone.0019309.


Antitumor DNA vaccination against the Sox2 transcription factor.

Polakova I, Duskova M, Smahel M.

Int J Oncol. 2014 Jul;45(1):139-46. doi: 10.3892/ijo.2014.2402.


Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells.

Yang J, Chai L, Fowles TC, Alipio Z, Xu D, Fink LM, Ward DC, Ma Y.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19756-61. doi: 10.1073/pnas.0809321105.


Oct4 and Sox2 directly regulate expression of another pluripotency transcription factor, Zfp206, in embryonic stem cells.

Wang ZX, Teh CH, Kueh JL, Lufkin T, Robson P, Stanton LW.

J Biol Chem. 2007 Apr 27;282(17):12822-30.


VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2.

Zhao D, Pan C, Sun J, Gilbert C, Drews-Elger K, Azzam DJ, Picon-Ruiz M, Kim M, Ullmer W, El-Ashry D, Creighton CJ, Slingerland JM.

Oncogene. 2015 Jun 11;34(24):3107-19. doi: 10.1038/onc.2014.257.

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