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Items: 1 to 20 of 92

1.

Enhancing and limiting endothelin-1 signaling with a cell-penetrating peptide mimicking the third intracellular loop of the ETB receptor.

Sallum CO, Wilson JL, Rupasinghe C, Berg E, Yu J, Green DS, Taylor L, Mierke D, Polgar P.

Chem Biol Drug Des. 2012 Sep;80(3):374-81. doi: 10.1111/j.1747-0285.2012.01405.x. Epub 2012 Jun 27.

2.

Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells.

Chen QW, Edvinsson L, Xu CB.

BMC Cell Biol. 2009 Jul 3;10:52. doi: 10.1186/1471-2121-10-52.

3.

Endothelin-1 activation of ETB receptors leads to a reduced cellular proliferative rate and an increased cellular footprint.

Wilson JL, Taylor L, Polgar P.

Exp Cell Res. 2012 Jun 10;318(10):1125-33. doi: 10.1016/j.yexcr.2012.03.029. Epub 2012 Apr 4.

4.

A cell permeable peptide targeting the intracellular loop 2 of endothelin B receptor reduces pulmonary hypertension in a hypoxic rat model.

Green DS, Rupasinghe C, Warburton R, Wilson JL, Sallum CO, Taylor L, Yatawara A, Mierke D, Polgar P, Hill N.

PLoS One. 2013 Nov 27;8(11):e81309. doi: 10.1371/journal.pone.0081309. eCollection 2013 Nov 27.

5.

Altered expression and signal transduction of endothelin-1 receptors in heritable and idiopathic pulmonary arterial hypertension.

Yu J, Taylor L, Wilson J, Comhair S, Erzurum S, Polgar P.

J Cell Physiol. 2013 Feb;228(2):322-9. doi: 10.1002/jcp.24132.

6.

Endothelin-1, the unfolded protein response, and persistent inflammation: role of pulmonary artery smooth muscle cells.

Yeager ME, Belchenko DD, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR.

Am J Respir Cell Mol Biol. 2012 Jan;46(1):14-22. doi: 10.1165/rcmb.2010-0506OC.

7.

C-terminus of ETA/ETB receptors regulate endothelin-1 signal transmission.

Yatawara A, Wilson JL, Taylor L, Polgar P, Mierke DF.

J Pept Sci. 2013 Apr;19(4):257-62. doi: 10.1002/psc.2499. Epub 2013 Feb 25.

8.

Identification of ETA and ETB binding domains using ET-derived photoprobes.

Aubin J, Létourneau M, Francoeur E, Burgeon E, Fournier A.

Biochimie. 2008 Jun;90(6):918-29. doi: 10.1016/j.biochi.2008.02.015. Epub 2008 Mar 4.

PMID:
18343229
9.

N-terminal proteolysis of the endothelin B receptor abolishes its ability to induce EGF receptor transactivation and contractile protein expression in vascular smooth muscle cells.

Grantcharova E, Reusch HP, Grossmann S, Eichhorst J, Krell HW, Beyermann M, Rosenthal W, Oksche A.

Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1288-96. Epub 2006 Apr 6.

10.

Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension.

Yamanaka R, Otsuka F, Nakamura K, Yamashita M, Otani H, Takeda M, Matsumoto Y, Kusano KF, Ito H, Makino H.

Hypertens Res. 2010 May;33(5):435-45. doi: 10.1038/hr.2010.16. Epub 2010 Feb 26.

PMID:
20186146
11.

Targeting receptor tyrosine kinases and their downstream signaling with cell-penetrating peptides in human pulmonary artery smooth muscle and endothelial cells.

Yu J, Rupasinghe C, Wilson JL, Taylor L, Rahimi N, Mierke D, Polgar P.

Chem Biol Drug Des. 2015 May;85(5):586-97. doi: 10.1111/cbdd.12446. Epub 2014 Nov 5.

12.

Limiting angiotensin II signaling with a cell-penetrating peptide mimicking the second intracellular loop of the angiotensin II type-I receptor.

Yu J, Taylor L, Mierke D, Berg E, Shia M, Fishman J, Sallum C, Polgar P.

Chem Biol Drug Des. 2010 Jul;76(1):70-6. doi: 10.1111/j.1747-0285.2010.00985.x. Epub 2010 May 18.

13.

Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist.

Nishikibe M, Ohta H, Okada M, Ishikawa K, Hayama T, Fukuroda T, Noguchi K, Saito M, Kanoh T, Ozaki S, Kamei T, Hara K, William D, Kivlighn S, Krause S, Gabel R, Zingaro G, Nolan N, O'Brien J, Clayton F, Lynch J, Pettibone D, Siegl P.

J Pharmacol Exp Ther. 1999 Jun;289(3):1262-70.

14.

NAADP-induced Ca(2+ signaling in response to endothelin is via the receptor subtype B and requires the integrity of lipid rafts/caveolae.

Gambara G, Billington RA, Debidda M, D'Alessio A, Palombi F, Ziparo E, Genazzani AA, Filippini A.

J Cell Physiol. 2008 Aug;216(2):396-404. doi: 10.1002/jcp.21407.

PMID:
18288637
15.

Enhanced expression of Gqα and PLC-β1 proteins contributes to vascular smooth muscle cell hypertrophy in SHR: role of endogenous angiotensin II and endothelin-1.

Atef ME, Anand-Srivastava MB.

Am J Physiol Cell Physiol. 2014 Jul 1;307(1):C97-106. doi: 10.1152/ajpcell.00337.2013. Epub 2014 Apr 23.

16.

Differential endothelin receptor expression and function in rat myometrial cells and leiomyoma ELT3 cells.

Raymond MN, Robin P, De Zen F, Vilain G, Tanfin Z.

Endocrinology. 2009 Oct;150(10):4766-76. doi: 10.1210/en.2009-0118. Epub 2009 Jul 23.

17.

Endothelin-1 and Endothelin-3 Regulate Endothelin Receptor Expression in Rat Coronary Arteries.

Skovsted GF, Kilic S, Edvinsson L.

Basic Clin Pharmacol Toxicol. 2015 Nov;117(5):297-305. doi: 10.1111/bcpt.12407. Epub 2015 May 18.

18.

PTHrP fragments 1-16 and 1-23 do not bind to either the ETA or the ETB endothelin receptors.

Langlois C, Létourneau M, Turcotte K, Detheux M, Fournier A.

Peptides. 2005 Aug;26(8):1436-40. Epub 2005 Apr 20.

PMID:
16042983
19.

Transmembrane helix 7 of the endothelin B receptor regulates downstream signaling.

Vichi P, Whelchel A, Posada J.

J Biol Chem. 1999 Apr 9;274(15):10331-8.

20.

Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.

Shi-Wen X, Rodríguez-Pascual F, Lamas S, Holmes A, Howat S, Pearson JD, Dashwood MR, du Bois RM, Denton CP, Black CM, Abraham DJ, Leask A.

Mol Cell Biol. 2006 Jul;26(14):5518-27.

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