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Items: 1 to 20 of 91

1.

Computational approaches to improve aggrecanase-1 inhibitory activity of (4-keto) phenoxy) methyl biphenyl-4-sulfonamide: group based QSAR and docking studies.

Sivakumar PM, Selvaraj NV, Ramesh G, Mohanapriya J, Prabhawathi V, Doble M.

Med Chem. 2012 Jul;8(4):673-82.

PMID:
22548335
2.

Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.

Hopper DW, Vera MD, How D, Sabatini J, Xiang JS, Ipek M, Thomason J, Hu Y, Feyfant E, Wang Q, Georgiadis KE, Reifenberg E, Sheldon RT, Keohan CC, Majumdar MK, Morris EA, Skotnicki J, Sum PE.

Bioorg Med Chem Lett. 2009 May 1;19(9):2487-91. doi: 10.1016/j.bmcl.2009.03.056. Epub 2009 Mar 18.

PMID:
19329309
3.

Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition.

Hu Y, Xing L, Thomason JR, Xiang J, Ipek M, Guler S, Li H, Sabatini J, Chockalingam P, Reifenberg E, Sheldon R, Morris EA, Georgiadis KE, Tam S.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6800-3. doi: 10.1016/j.bmcl.2011.09.036. Epub 2011 Sep 18.

PMID:
21982494
4.

Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.

Xiang JS, Hu Y, Rush TS, Thomason JR, Ipek M, Sum PE, Abrous L, Sabatini JJ, Georgiadis K, Reifenberg E, Majumdar M, Morris EA, Tam S.

Bioorg Med Chem Lett. 2006 Jan 15;16(2):311-6. Epub 2005 Nov 3.

PMID:
16275085
5.

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.

Nuti E, Santamaria S, Casalini F, Yamamoto K, Marinelli L, La Pietra V, Novellino E, Orlandini E, Nencetti S, Marini AM, Salerno S, Taliani S, Da Settimo F, Nagase H, Rossello A.

Eur J Med Chem. 2013 Apr;62:379-94. doi: 10.1016/j.ejmech.2012.12.058. Epub 2013 Jan 11.

PMID:
23376997
6.

The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis.

De Savi C, Pape A, Cumming JG, Ting A, Smith PD, Burrows JN, Mills M, Davies C, Lamont S, Milne D, Cook C, Moore P, Sawyer Y, Gerhardt S.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1376-81. doi: 10.1016/j.bmcl.2011.01.036. Epub 2011 Jan 18.

PMID:
21300546
7.

Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.

De Savi C, Pape A, Sawyer Y, Milne D, Davies C, Cumming JG, Ting A, Lamont S, Smith PD, Tart J, Page K, Moore P.

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3301-6. doi: 10.1016/j.bmcl.2011.04.028. Epub 2011 Apr 13.

PMID:
21536437
8.

Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.

Durham TB, Klimkowski VJ, Rito CJ, Marimuthu J, Toth JL, Liu C, Durbin JD, Stout SL, Adams L, Swearingen C, Lin C, Chambers MG, Thirunavukkarasu K, Wiley MR.

J Med Chem. 2014 Dec 26;57(24):10476-85. doi: 10.1021/jm501522n. Epub 2014 Dec 5.

PMID:
25415648
9.

Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes.

Takizawa M, Yatabe T, Okada A, Chijiiwa M, Mochizuki S, Ghosh P, Okada Y.

FEBS Lett. 2008 Aug 20;582(19):2945-9. doi: 10.1016/j.febslet.2008.07.036. Epub 2008 Jul 29.

10.

TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4.

Wayne GJ, Deng SJ, Amour A, Borman S, Matico R, Carter HL, Murphy G.

J Biol Chem. 2007 Jul 20;282(29):20991-8. Epub 2007 Apr 30.

11.

Molecular docking and dynamics simulation study on the influence of Zn2+ on the binding modes of aggrecanase with its inhibitors.

Suganya PS, Kalva S, Saleena LM.

Comb Chem High Throughput Screen. 2014;17(10):891-903.

PMID:
25386707
12.

A QSAR study on relationship between structure of sulfonamides and their carbonic anhydrase inhibitory activity using the eigenvalue (EVA) method.

Oltulu O, Yaşar MM, Eroğlu E.

Eur J Med Chem. 2009 Sep;44(9):3439-44. doi: 10.1016/j.ejmech.2009.02.016. Epub 2009 Feb 21.

PMID:
19303173
13.

N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2).

Gilbert AM, Bursavich MG, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6454-7. doi: 10.1016/j.bmcl.2008.10.065. Epub 2008 Oct 18.

PMID:
18974001
14.

Molecular design of new aggrecanases-2 inhibitors.

Shan ZJ, Zhai HL, Huang XY, Li LN, Zhang XY.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5339-50. doi: 10.1016/j.bmcl.2013.07.060. Epub 2013 Aug 2.

PMID:
23953188
15.

Suppression of aggrecanase: a novel protective mechanism of dehydroepiandrosterone in osteoarthritis?

Huang K, Wu LD.

Mol Biol Rep. 2010 Mar;37(3):1241-5. doi: 10.1007/s11033-009-9495-5. Epub 2009 Mar 10. Review.

PMID:
19277895
16.

Structure-activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors.

Peng L, Duan L, Liu X, Shen M, Li Y, Yan J, Li H, Ding K.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4457-61. doi: 10.1016/j.bmcl.2011.06.009. Epub 2011 Jun 16.

PMID:
21733683
17.

Development of predictive 3D-QSAR CoMFA and CoMSIA models for beta-aminohydroxamic acid-derived tumor necrosis factor-alpha converting enzyme inhibitors.

Murumkar PR, Gupta SD, Zambre VP, Giridhar R, Yadav MR.

Chem Biol Drug Des. 2009 Jan;73(1):97-107. doi: 10.1111/j.1747-0285.2008.00737.x.

PMID:
19152638
18.

The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage.

Tortorella M, Pratta M, Liu RQ, Abbaszade I, Ross H, Burn T, Arner E.

J Biol Chem. 2000 Aug 18;275(33):25791-7.

19.

3D-quantitative structure-activity relationship studies on benzothiadiazepine hydroxamates as inhibitors of tumor necrosis factor-alpha converting enzyme.

Murumkar PR, Giridhar R, Yadav MR.

Chem Biol Drug Des. 2008 Apr;71(4):363-73. doi: 10.1111/j.1747-0285.2008.00639.x. Epub 2008 Feb 14.

PMID:
18284555
20.

ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.

Hashimoto G, Shimoda M, Okada Y.

J Biol Chem. 2004 Jul 30;279(31):32483-91. Epub 2004 May 25.

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