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Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer.

Wang JG, Geddings JE, Aleman MM, Cardenas JC, Chantrathammachart P, Williams JC, Kirchhofer D, Bogdanov VY, Bach RR, Rak J, Church FC, Wolberg AS, Pawlinski R, Key NS, Yeh JJ, Mackman N.

Blood. 2012 Jun 7;119(23):5543-52. doi: 10.1182/blood-2012-01-402156. Epub 2012 Apr 30.


Tissue factor expressed by circulating cancer cell-derived microparticles drastically increases the incidence of deep vein thrombosis in mice.

Thomas GM, Brill A, Mezouar S, Crescence L, Gallant M, Dubois C, Wagner DD.

J Thromb Haemost. 2015 Jul;13(7):1310-9. doi: 10.1111/jth.13002. Epub 2015 Jun 8.


Tumor-derived tissue factor-positive microparticles and venous thrombosis in cancer patients.

Geddings JE, Mackman N.

Blood. 2013 Sep 12;122(11):1873-80. doi: 10.1182/blood-2013-04-460139. Epub 2013 Jun 24. Review.


Inhibition of platelet activation prevents the P-selectin and integrin-dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasis in vivo.

Mezouar S, Darbousset R, Dignat-George F, Panicot-Dubois L, Dubois C.

Int J Cancer. 2015 Jan 15;136(2):462-75. doi: 10.1002/ijc.28997. Epub 2014 Jun 9.


Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis.

Ramacciotti E, Hawley AE, Farris DM, Ballard NE, Wrobleski SK, Myers DD Jr, Henke PK, Wakefield TW.

Thromb Haemost. 2009 Apr;101(4):748-54.


Human pancreatic tumors grown in mice release tissue factor-positive microvesicles that increase venous clot size.

Hisada Y, Ay C, Auriemma AC, Cooley BC, Mackman N.

J Thromb Haemost. 2017 Nov;15(11):2208-2217. doi: 10.1111/jth.13809. Epub 2017 Sep 20.


Tissue factor-bearing microparticles derived from tumor cells: impact on coagulation activation.

Davila M, Amirkhosravi A, Coll E, Desai H, Robles L, Colon J, Baker CH, Francis JL.

J Thromb Haemost. 2008 Sep;6(9):1517-24. doi: 10.1111/j.1538-7836.2008.02987.x. Epub 2008 Apr 22.


Microparticle association and heterogeneity of tumor-derived tissue factor in plasma: is it important for coagulation activation?

Davila M, Robles-Carrillo L, Unruh D, Huo Q, Gardiner C, Sargent IL, Adam M, Woodhams BJ, Francis JL, Bogdanov VY, Amirkhosravi A.

J Thromb Haemost. 2014 Feb;12(2):186-96. doi: 10.1111/jth.12475.


Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model.

Hampton AL, Diaz JA, Hawley AE, Wrobleski SK, Wang JG, Lee RD, Kirchhofer D, Sigler RE, Wakefield TW, Mackman N, Myers DD Jr.

Thromb Res. 2012 Oct;130(4):640-5. doi: 10.1016/j.thromres.2011.11.027. Epub 2011 Dec 20.


Microparticle-associated tissue factor activity in patients with acute unprovoked deep vein thrombosis and during the course of one year.

Thaler J, Koppensteiner R, Pabinger I, Ay C, Gremmel T.

Thromb Res. 2014 Nov;134(5):1093-6. doi: 10.1016/j.thromres.2014.07.041. Epub 2014 Aug 22.


Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model.

Hobbs JE, Zakarija A, Cundiff DL, Doll JA, Hymen E, Cornwell M, Crawford SE, Liu N, Signaevsky M, Soff GA.

Thromb Res. 2007;120 Suppl 2:S13-21. Erratum in: Thromb Res. 2008;123(1):187-90.


Cancer cell-derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo.

Thomas GM, Panicot-Dubois L, Lacroix R, Dignat-George F, Lombardo D, Dubois C.

J Exp Med. 2009 Aug 31;206(9):1913-27. doi: 10.1084/jem.20082297. Epub 2009 Aug 10.


Tissue factor procoagulant activity of plasma microparticles is increased in patients with early-stage prostate cancer.

Haubold K, Rink M, Spath B, Friedrich M, Chun FK, Marx G, Amirkhosravi A, Francis JL, Bokemeyer C, Eifrig B, Langer F.

Thromb Haemost. 2009 Jun;101(6):1147-55.


Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice.

Geddings JE, Hisada Y, Boulaftali Y, Getz TM, Whelihan M, Fuentes R, Dee R, Cooley BC, Key NS, Wolberg AS, Bergmeier W, Mackman N.

J Thromb Haemost. 2016 Jan;14(1):153-66. doi: 10.1111/jth.13181. Epub 2015 Dec 11. Erratum in: J Thromb Haemost. 2016 Dec;14 (12 ):2566.


Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays.

Hisada Y, Alexander W, Kasthuri R, Voorhees P, Mobarrez F, Taylor A, McNamara C, Wallen H, Witkowski M, Key NS, Rauch U, Mackman N.

Thromb Res. 2016 Mar;139:90-7. doi: 10.1016/j.thromres.2016.01.011. Epub 2016 Jan 18. Review.


Aging is associated with impaired thrombus resolution in a mouse model of stasis induced thrombosis.

McDonald AP, Meier TR, Hawley AE, Thibert JN, Farris DM, Wrobleski SK, Henke PK, Wakefield TW, Myers DD Jr.

Thromb Res. 2010 Jan;125(1):72-8. doi: 10.1016/j.thromres.2009.06.005. Epub 2009 Jul 18.


Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice.

Wang JG, Manly D, Kirchhofer D, Pawlinski R, Mackman N.

J Thromb Haemost. 2009 Jul;7(7):1092-8. doi: 10.1111/j.1538-7836.2009.03448.x. Epub 2009 Apr 27.


Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis.

Mackman N, Tilley RE, Key NS.

Arterioscler Thromb Vasc Biol. 2007 Aug;27(8):1687-93. Epub 2007 Jun 7. Review.


Microparticle-associated tissue factor activity in patients with metastatic pancreatic cancer and its effect on fibrin clot formation.

Thaler J, Koder S, Kornek G, Pabinger I, Ay C.

Transl Res. 2014 Feb;163(2):145-50. doi: 10.1016/j.trsl.2013.06.009. Epub 2013 Aug 21.


Expression of tissue factor in pancreatic adenocarcinoma is associated with activation of coagulation.

Haas SL, Jesnowski R, Steiner M, Hummel F, Ringel J, Burstein C, Nizze H, Liebe S, Löhr JM.

World J Gastroenterol. 2006 Aug 14;12(30):4843-9.

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