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PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity.

Seong HA, Jung H, Manoharan R, Ha H.

J Biol Chem. 2012 Jun 15;287(25):20811-22. doi: 10.1074/jbc.M111.331827.


Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation.

Jung H, Seong HA, Ha H.

J Biol Chem. 2008 Dec 12;283(50):34541-53. doi: 10.1074/jbc.M807219200.


Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation.

Seong HA, Jung H, Ichijo H, Ha H.

J Biol Chem. 2010 Jan 22;285(4):2397-414. doi: 10.1074/jbc.M109.064295.


Thioredoxin inhibits MPK38-induced ASK1, TGF-β, and p53 function in a phosphorylation-dependent manner.

Manoharan R, Seong HA, Ha H.

Free Radic Biol Med. 2013 Oct;63:313-24. doi: 10.1016/j.freeradbiomed.2013.05.020.


Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction.

Jung H, Seong HA, Manoharan R, Ha H.

J Biol Chem. 2010 Jan 1;285(1):54-70. doi: 10.1074/jbc.M109.045229.


Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation.

Seong HA, Ha H.

J Biol Chem. 2012 Jun 15;287(25):20797-810. doi: 10.1074/jbc.M112.347757.


RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation.

Zhang H, Zhang H, Lin Y, Li J, Pober JS, Min W.

J Biol Chem. 2007 May 18;282(20):14788-96. Erratum in: J Biol Chem. 2007 Sep 14;282(37):27556. Zhang, Rong [corrected to Zhang, Haifeng].


Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

Fujita N, Sato S, Ishida A, Tsuruo T.

J Biol Chem. 2002 Mar 22;277(12):10346-53.


The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.

Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR.

Curr Biol. 2000 Apr 20;10(8):439-48.


Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.

Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR.

J Biol Chem. 1999 Dec 24;274(52):37400-6.


Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.

Kim S, Jee K, Kim D, Koh H, Chung J.

J Biol Chem. 2001 Apr 20;276(16):12864-70.

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