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Items: 1 to 20 of 110

1.

Evaluation of bis-alkylamidoxime O-alkylsulfonates as orally available antimalarials.

Degardin M, Wein S, Gouni S, Tran Van Ba C, Duckert JF, Durand T, Escale R, Vial H, Vo-Hoang Y.

ChemMedChem. 2012 Jun;7(6):991-1001. doi: 10.1002/cmdc.201200112. Epub 2012 Apr 27.

PMID:
22544438
2.

Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents.

Ouattara M, Wein S, Denoyelle S, Ortial S, Durand T, Escale R, Vial H, Vo-Hoang Y.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):624-6. doi: 10.1016/j.bmcl.2008.12.058. Epub 2008 Dec 24.

PMID:
19124242
3.

Development of the first oral bioprecursors of bis-alkylguanidine antimalarial drugs.

Degardin M, Wein S, Duckert JF, Maynadier M, Guy A, Durand T, Escale R, Vial H, Vo-Hoang Y.

ChemMedChem. 2014 Feb;9(2):300-4. doi: 10.1002/cmdc.201300419. Epub 2014 Jan 8.

PMID:
24403182
4.

Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials.

Caldarelli SA, Boisbrun M, Alarcon K, Hamzé A, Ouattara M, Salom-Roig X, Maynadier M, Wein S, Peyrottes S, Pellet A, Calas M, Vial H.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3953-6. doi: 10.1016/j.bmcl.2010.05.001. Epub 2010 May 10.

PMID:
20605450
5.

Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives.

Ouattara M, Wein S, Calas M, Hoang YV, Vial H, Escale R.

Bioorg Med Chem Lett. 2007 Feb 1;17(3):593-6. Epub 2006 Nov 10.

PMID:
17123818
6.

Pharmacological properties of a new antimalarial bisthiazolium salt, T3, and a corresponding prodrug, TE3.

Nicolas O, Margout D, Taudon N, Wein S, Calas M, Vial HJ, Bressolle FM.

Antimicrob Agents Chemother. 2005 Sep;49(9):3631-9.

7.

Disulfide prodrugs of albitiazolium (T3/SAR97276): synthesis and biological activities.

Caldarelli SA, Hamel M, Duckert JF, Ouattara M, Calas M, Maynadier M, Wein S, Périgaud C, Pellet A, Vial HJ, Peyrottes S.

J Med Chem. 2012 May 24;55(10):4619-28. doi: 10.1021/jm3000328. Epub 2012 May 16.

PMID:
22591034
8.
9.

Antimalarial activity of a riboflavin analog against Plasmodium vinckei in vivo and Plasmodium falciparum in vitro.

Cowden WB, Butcher GA, Hunt NH, Clark IA, Yoneda F.

Am J Trop Med Hyg. 1987 Nov;37(3):495-500.

PMID:
3688306
10.

N-substituted bis-C-alkyloxadiazolones as dual effectors: efficient intermediates to amidoximes or amidines and prodrug candidates of potent antimalarials.

Degardin M, Wein S, Durand T, Escale R, Vial H, Vo-Hoang Y.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5233-6. doi: 10.1016/j.bmcl.2009.07.001. Epub 2009 Jul 4.

PMID:
19643611
11.

Pharmacokinetic properties and metabolism of a new potent antimalarial N-alkylamidine compound, M64, and its corresponding bioprecursors.

Margout D, Gattacceca F, Moarbess G, Wein S, Tran van Ba C, Le Pape S, Berger O, Escale R, Vial HJ, Bressolle FM.

Eur J Pharm Sci. 2011 Jan 18;42(1-2):81-90. doi: 10.1016/j.ejps.2010.10.012. Epub 2010 Nov 2.

PMID:
21050886
12.

Mono- and bis-thiazolium salts have potent antimalarial activity.

Hamzé A, Rubi E, Arnal P, Boisbrun M, Carcel C, Salom-Roig X, Maynadier M, Wein S, Vial H, Calas M.

J Med Chem. 2005 May 19;48(10):3639-43.

PMID:
15887971
13.

Phenoxypropoxybiguanides, prodrugs of DHFR-inhibiting diaminotriazine antimalarials.

Jensen NP, Ager AL, Bliss RA, Canfield CJ, Kotecka BM, Rieckmann KH, Terpinski J, Jacobus DP.

J Med Chem. 2001 Nov 8;44(23):3925-31.

PMID:
11689078
14.

Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives.

Liu X, Wang X, Li Q, Kozar MP, Melendez V, O'Neil MT, Lin AJ.

J Med Chem. 2011 Jul 14;54(13):4523-35. doi: 10.1021/jm200111g. Epub 2011 May 31.

PMID:
21627120
15.

Dual molecules as new antimalarials.

Salom-Roig XJ, Hamzé A, Calas M, Vial HJ.

Comb Chem High Throughput Screen. 2005 Feb;8(1):49-62. Review.

PMID:
15720197
16.

Reverse-benzamidine antimalarial agents: design, synthesis, and biological evaluation.

Berger O, Wein S, Duckert JF, Maynadier M, El Fangour S, Escale R, Durand T, Vial H, Vo-Hoang Y.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5815-7. doi: 10.1016/j.bmcl.2010.07.124. Epub 2010 Aug 3.

PMID:
20800484
17.

Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues.

Berger O, Kaniti A, van Ba CT, Vial H, Ward SA, Biagini GA, Bray PG, O'Neill PM.

ChemMedChem. 2011 Nov 4;6(11):2094-108. doi: 10.1002/cmdc.201100265. Epub 2011 Sep 8.

PMID:
21905228
18.

A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.

Davioud-Charvet E, Delarue S, Biot C, Schwöbel B, Boehme CC, Müssigbrodt A, Maes L, Sergheraert C, Grellier P, Schirmer RH, Becker K.

J Med Chem. 2001 Nov 22;44(24):4268-76.

PMID:
11708927
19.

Synthesis of quinolinyl chalcones and evaluation of their antimalarial activity.

Domínguez JN, Charris JE, Lobo G, Gamboa de Domínguez N, Moreno MM, Riggione F, Sanchez E, Olson J, Rosenthal PJ.

Eur J Med Chem. 2001 Jun;36(6):555-60.

PMID:
11525846
20.

Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol.

Sato A, Hiramoto A, Morita M, Matsumoto M, Komich Y, Nakase Y, Tanigawa N, Hiraoka O, Hiramoto K, Hayatsu H, Higaki K, Kawai S, Masuyama A, Nojima M, Wataya Y, Kim HS.

Parasitol Int. 2011 Sep;60(3):270-3. doi: 10.1016/j.parint.2011.04.001. Epub 2011 Apr 8.

PMID:
21501696

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