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Items: 1 to 20 of 109

1.

Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit.

Senatore A, Colleoni S, Verderio C, Restelli E, Morini R, Condliffe SB, Bertani I, Mantovani S, Canovi M, Micotti E, Forloni G, Dolphin AC, Matteoli M, Gobbi M, Chiesa R.

Neuron. 2012 Apr 26;74(2):300-13. doi: 10.1016/j.neuron.2012.02.027.

2.

Cellular prion protein is implicated in the regulation of local Ca2+ movements in cerebellar granule neurons.

Lazzari C, Peggion C, Stella R, Massimino ML, Lim D, Bertoli A, Sorgato MC.

J Neurochem. 2011 Mar;116(5):881-90. doi: 10.1111/j.1471-4159.2010.07015.x. Epub 2011 Jan 7.

3.

Analysis of the cerebellar proteome in a transgenic mouse model of inherited prion disease reveals preclinical alteration of calcineurin activity.

Biasini E, Massignan T, Fioriti L, Rossi V, Dossena S, Salmona M, Forloni G, Bonetto V, Chiesa R.

Proteomics. 2006 May;6(9):2823-34.

PMID:
16572473
4.

Prion protein with an insertional mutation accumulates on axonal and dendritic plasmalemma and is associated with distinctive ultrastructural changes.

Jeffrey M, Goodsir C, McGovern G, Barmada SJ, Medrano AZ, Harris DA.

Am J Pathol. 2009 Sep;175(3):1208-17. doi: 10.2353/ajpath.2009.090125. Epub 2009 Aug 21.

5.

Altered neuron excitability and synaptic plasticity in the cerebellar granular layer of juvenile prion protein knock-out mice with impaired motor control.

Prestori F, Rossi P, Bearzatto B, Lainé J, Necchi D, Diwakar S, Schiffmann SN, Axelrad H, D'Angelo E.

J Neurosci. 2008 Jul 9;28(28):7091-103. doi: 10.1523/JNEUROSCI.0409-08.2008.

6.

Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.

Stewart RS, Piccardo P, Ghetti B, Harris DA.

J Neurosci. 2005 Mar 30;25(13):3469-77.

7.

Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.

Chiesa R, Piccardo P, Dossena S, Nowoslawski L, Roth KA, Ghetti B, Harris DA.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):238-43. Epub 2004 Dec 23.

8.

Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation.

Chiesa R, Drisaldi B, Quaglio E, Migheli A, Piccardo P, Ghetti B, Harris DA.

Proc Natl Acad Sci U S A. 2000 May 9;97(10):5574-9.

9.

Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction.

Quaglio E, Restelli E, Garofoli A, Dossena S, De Luigi A, Tagliavacca L, Imperiale D, Migheli A, Salmona M, Sitia R, Forloni G, Chiesa R.

PLoS One. 2011 Apr 29;6(4):e19339. doi: 10.1371/journal.pone.0019339.

10.

Potential molecular mechanisms for decreased synaptic glutamate release in dysbindin-1 mutant mice.

Saggu S, Cannon TD, Jentsch JD, Lavin A.

Schizophr Res. 2013 May;146(1-3):254-63. doi: 10.1016/j.schres.2013.01.037. Epub 2013 Mar 6.

11.

Prion protein regulates glutathione metabolism and neural glutamate and cysteine uptake via excitatory amino acid transporter 3.

Guitart K, Loers G, Schachner M, Kleene R.

J Neurochem. 2015 May;133(4):558-71. doi: 10.1111/jnc.13071. Epub 2015 Mar 17.

12.

Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.

Bouybayoune I, Mantovani S, Del Gallo F, Bertani I, Restelli E, Comerio L, Tapella L, Baracchi F, Fernández-Borges N, Mangieri M, Bisighini C, Beznoussenko GV, Paladini A, Balducci C, Micotti E, Forloni G, Castilla J, Fiordaliso F, Tagliavini F, Imeri L, Chiesa R.

PLoS Pathog. 2015 Apr 16;11(4):e1004796. doi: 10.1371/journal.ppat.1004796. eCollection 2015 Apr. Erratum in: PLoS Pathog. 2015 Jul;11(7):e1005046.

13.

Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model.

Dossena S, Imeri L, Mangieri M, Garofoli A, Ferrari L, Senatore A, Restelli E, Balducci C, Fiordaliso F, Salio M, Bianchi S, Fioriti L, Morbin M, Pincherle A, Marcon G, Villani F, Carli M, Tagliavini F, Forloni G, Chiesa R.

Neuron. 2008 Nov 26;60(4):598-609. doi: 10.1016/j.neuron.2008.09.008.

14.

Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations.

Fioriti L, Dossena S, Stewart LR, Stewart RS, Harris DA, Forloni G, Chiesa R.

J Biol Chem. 2005 Mar 25;280(12):11320-8. Epub 2005 Jan 4.

15.

Presynaptic CaV2 calcium channel traffic requires CALF-1 and the alpha(2)delta subunit UNC-36.

Saheki Y, Bargmann CI.

Nat Neurosci. 2009 Oct;12(10):1257-65. doi: 10.1038/nn.2383. Epub 2009 Aug 30.

16.

Selective processing and metabolism of disease-causing mutant prion proteins.

Ashok A, Hegde RS.

PLoS Pathog. 2009 Jun;5(6):e1000479. doi: 10.1371/journal.ppat.1000479. Epub 2009 Jun 19.

17.

Identification of cryptic nuclear localization signals in the prion protein.

Gu Y, Hinnerwisch J, Fredricks R, Kalepu S, Mishra RS, Singh N.

Neurobiol Dis. 2003 Mar;12(2):133-49.

PMID:
12667468
18.

Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration.

Furrer SA, Mohanachandran MS, Waldherr SM, Chang C, Damian VA, Sopher BL, Garden GA, La Spada AR.

J Neurosci. 2011 Nov 9;31(45):16269-78. doi: 10.1523/JNEUROSCI.4000-11.2011.

19.

Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway.

Massignan T, Biasini E, Lauranzano E, Veglianese P, Pignataro M, Fioriti L, Harris DA, Salmona M, Chiesa R, Bonetto V.

Mol Cell Proteomics. 2010 Apr;9(4):611-22. doi: 10.1074/mcp.M900271-MCP200. Epub 2009 Dec 7.

20.

Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion.

Biasini E, Medrano AZ, Thellung S, Chiesa R, Harris DA.

J Neurochem. 2008 Mar;104(5):1293-308. Epub 2007 Nov 21.

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