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Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.

Verret L, Mann EO, Hang GB, Barth AM, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, Palop JJ.

Cell. 2012 Apr 27;149(3):708-21. doi: 10.1016/j.cell.2012.02.046.


Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease.

Corbett BF, Leiser SC, Ling HP, Nagy R, Breysse N, Zhang X, Hazra A, Brown JT, Randall AD, Wood A, Pangalos MN, Reinhart PH, Chin J.

J Neurosci. 2013 Apr 17;33(16):7020-6. doi: 10.1523/JNEUROSCI.2325-12.2013. Erratum in: J Neurosci. 2013 Jun 26;33(26):10934. Brown, Jon T [added]; Randall, Andrew D [added].


Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.

Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu GQ, Palop JJ, Mucke L.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):E2895-903. doi: 10.1073/pnas.1121081109.


Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L.

J Neurosci. 2011 Jan 12;31(2):700-11. doi: 10.1523/JNEUROSCI.4152-10.2011.


Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation.

Tong LM, Djukic B, Arnold C, Gillespie AK, Yoon SY, Wang MM, Zhang O, Knoferle J, Rubenstein JL, Alvarez-Buylla A, Huang Y.

J Neurosci. 2014 Jul 16;34(29):9506-15. doi: 10.1523/JNEUROSCI.0693-14.2014.


Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.

Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L.

Neuron. 2007 Sep 6;55(5):697-711.


Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L.

J Neurosci. 2005 Oct 19;25(42):9694-703.


Synergistic exacerbation of mitochondrial and synaptic dysfunction and resultant learning and memory deficit in a mouse model of diabetic Alzheimer's disease.

Wang Y, Wu L, Li J, Fang D, Zhong C, Chen JX, Yan SS.

J Alzheimers Dis. 2015;43(2):451-63. doi: 10.3233/JAD-140972.


Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.

Chin J, Massaro CM, Palop JJ, Thwin MT, Yu GQ, Bien-Ly N, Bender A, Mucke L.

J Neurosci. 2007 Mar 14;27(11):2727-33.


Accelerated aging of the GABAergic septohippocampal pathway and decreased hippocampal rhythms in a mouse model of Alzheimer's disease.

Rubio SE, Vega-Flores G, Martínez A, Bosch C, Pérez-Mediavilla A, del Río J, Gruart A, Delgado-García JM, Soriano E, Pascual M.

FASEB J. 2012 Nov;26(11):4458-67. doi: 10.1096/fj.12-208413.


Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.

Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L.

J Neurosci. 2015 Feb 11;35(6):2358-71. doi: 10.1523/JNEUROSCI.5791-12.2015.


Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.

Wang C, Sun B, Zhou Y, Grubb A, Gan L.

J Biol Chem. 2012 Nov 16;287(47):39834-41. doi: 10.1074/jbc.M112.371641.


Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages.

Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA.

J Neurosci. 2014 Apr 23;34(17):5776-87. doi: 10.1523/JNEUROSCI.5288-13.2014.


Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.

Palop JJ, Chin J, Bien-Ly N, Massaro C, Yeung BZ, Yu GQ, Mucke L.

J Neurosci. 2005 Oct 19;25(42):9686-93.


Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits.

Palop JJ, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, Mucke L.

Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9572-7.


Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.

Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L.

J Neurosci. 2004 May 12;24(19):4692-7.


Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome.

Kalume F, Oakley JC, Westenbroek RE, Gile J, de la Iglesia HO, Scheuer T, Catterall WA.

Neurobiol Dis. 2015 May;77:141-54. doi: 10.1016/j.nbd.2015.02.016.


Impairments in neurogenesis are not tightly linked to depressive behavior in a transgenic mouse model of Alzheimer's disease.

Iascone DM, Padidam S, Pyfer MS, Zhang X, Zhao L, Chin J.

PLoS One. 2013 Nov 14;8(11):e79651. doi: 10.1371/journal.pone.0079651.


High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.

Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L.

J Neurosci. 2000 Jun 1;20(11):4050-8.


Dissecting the phenotypes of Dravet syndrome by gene deletion.

Rubinstein M, Han S, Tai C, Westenbroek RE, Hunker A, Scheuer T, Catterall WA.

Brain. 2015 Aug;138(Pt 8):2219-33. doi: 10.1093/brain/awv142.

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