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RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo.

Wu J, Liu C, Chen J, Yu X.

J Biol Chem. 2012 Jun 29;287(27):22919-26. doi: 10.1074/jbc.M112.351007. Epub 2012 Apr 25.


MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.

Shao G, Patterson-Fortin J, Messick TE, Feng D, Shanbhag N, Wang Y, Greenberg RA.

Genes Dev. 2009 Mar 15;23(6):740-54. doi: 10.1101/gad.1739609. Epub 2009 Mar 4.


RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.

Guzzo CM, Berndsen CE, Zhu J, Gupta V, Datta A, Greenberg RA, Wolberger C, Matunis MJ.

Sci Signal. 2012 Dec 4;5(253):ra88. doi: 10.1126/scisignal.2003485.


Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates.

Hu X, Paul A, Wang B.

J Biol Chem. 2012 Jul 20;287(30):25510-9. doi: 10.1074/jbc.M112.374116. Epub 2012 Jun 11.


The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.

Yan J, Kim YS, Yang XP, Li LP, Liao G, Xia F, Jetten AM.

Cancer Res. 2007 Jul 15;67(14):6647-56. Epub 2007 Jul 9.


Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.

Kim H, Chen J, Yu X.

Science. 2007 May 25;316(5828):1202-5.


RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.

Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA.

Science. 2007 May 25;316(5828):1198-202.


Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.

Wang B, Elledge SJ.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20759-63. Epub 2007 Dec 5.


Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function.

Nikkilä J, Coleman KA, Morrissey D, Pylkäs K, Erkko H, Messick TE, Karppinen SM, Amelina A, Winqvist R, Greenberg RA.

Oncogene. 2009 Apr 23;28(16):1843-52. doi: 10.1038/onc.2009.33. Epub 2009 Mar 23.


The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.

Coleman KA, Greenberg RA.

J Biol Chem. 2011 Apr 15;286(15):13669-80. doi: 10.1074/jbc.M110.213728. Epub 2011 Feb 18.


Loss of BRCA1-A complex function in RAP80 null tumor cells.

Bian C, Wu R, Cho K, Yu X.

PLoS One. 2012;7(7):e40406. doi: 10.1371/journal.pone.0040406. Epub 2012 Jul 6.


RAP80 is critical in maintaining genomic stability and suppressing tumor development.

Yin Z, Menendez D, Resnick MA, French JE, Janardhan KS, Jetten AM.

Cancer Res. 2012 Oct 1;72(19):5080-90. doi: 10.1158/0008-5472.CAN-12-1484. Epub 2012 Aug 15.


Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80.

Sato Y, Yoshikawa A, Mimura H, Yamashita M, Yamagata A, Fukai S.

EMBO J. 2009 Aug 19;28(16):2461-8. doi: 10.1038/emboj.2009.160. Epub 2009 Jun 18.


RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites.

Yan J, Jetten AM.

Cancer Lett. 2008 Nov 28;271(2):179-90. doi: 10.1016/j.canlet.2008.04.046. Epub 2008 Jun 11. Review.


MERIT40 facilitates BRCA1 localization and DNA damage repair.

Feng L, Huang J, Chen J.

Genes Dev. 2009 Mar 15;23(6):719-28. doi: 10.1101/gad.1770609. Epub 2009 Mar 4.


RAP80, ubiquitin and SUMO in the DNA damage response.

Lombardi PM, Matunis MJ, Wolberger C.

J Mol Med (Berl). 2017 Aug;95(8):799-807. doi: 10.1007/s00109-017-1561-1. Epub 2017 Jul 5. Review.


BRCA1, a 'complex' protein involved in the maintenance of genomic stability.

Savage KI, Harkin DP.

FEBS J. 2015 Feb;282(4):630-46. doi: 10.1111/febs.13150. Epub 2014 Dec 2. Review.


RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci.

Hu Y, Scully R, Sobhian B, Xie A, Shestakova E, Livingston DM.

Genes Dev. 2011 Apr 1;25(7):685-700. doi: 10.1101/gad.2011011. Epub 2011 Mar 15.


Histone ubiquitination associates with BRCA1-dependent DNA damage response.

Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X.

Mol Cell Biol. 2009 Feb;29(3):849-60. doi: 10.1128/MCB.01302-08. Epub 2008 Nov 17.


Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection.

Kakarougkas A, Ismail A, Katsuki Y, Freire R, Shibata A, Jeggo PA.

Nucleic Acids Res. 2013 Dec;41(22):10298-311. doi: 10.1093/nar/gkt802. Epub 2013 Sep 5.

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