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Items: 1 to 20 of 282

1.

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.

Mimura N, Fulciniti M, Gorgun G, Tai YT, Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H, Kiziltepe T, Ikeda H, Kawano Y, French M, Blumenthal M, Tam V, Kertesz NL, Malyankar UM, Hokenson M, Pham T, Zeng Q, Patterson JB, Richardson PG, Munshi NC, Anderson KC.

Blood. 2012 Jun 14;119(24):5772-81. doi: 10.1182/blood-2011-07-366633.

2.

Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells.

Chien W, Ding LW, Sun QY, Torres-Fernandez LA, Tan SZ, Xiao J, Lim SL, Garg M, Lee KL, Kitajima S, Takao S, Leong WZ, Sun H, Tokatly I, Poellinger L, Gery S, Koeffler PH.

Oncotarget. 2014 Jul 15;5(13):4881-94.

3.

Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells.

Wang FM, Galson DL, Roodman GD, Ouyang H.

Exp Hematol. 2011 Oct;39(10):999-1006. doi: 10.1016/j.exphem.2011.06.007.

4.
5.

ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage.

Guo FJ, Xiong Z, Lu X, Ye M, Han X, Jiang R.

Cell Signal. 2014 Feb;26(2):332-42. doi: 10.1016/j.cellsig.2013.11.018.

PMID:
24269637
6.

HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction.

Gupta S, Deepti A, Deegan S, Lisbona F, Hetz C, Samali A.

PLoS Biol. 2010 Jul 6;8(7):e1000410. doi: 10.1371/journal.pbio.1000410.

7.

Acute Endoplasmic Reticulum Stress-Independent Unconventional Splicing of XBP1 mRNA in the Nucleus of Mammalian Cells.

Wang Y, Xing P, Cui W, Wang W, Cui Y, Ying G, Wang X, Li B.

Int J Mol Sci. 2015 Jun 10;16(6):13302-21. doi: 10.3390/ijms160613302.

8.

The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.

Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ.

J Clin Invest. 2005 Feb;115(2):268-81.

9.

Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia.

Sun H, Lin DC, Guo X, Kharabi Masouleh B, Gery S, Cao Q, Alkan S, Ikezoe T, Akiba C, Paquette R, Chien W, Müller-Tidow C, Jing Y, Agelopoulos K, Müschen M, Koeffler HP.

Oncotarget. 2016 Apr 5;7(14):18736-49. doi: 10.18632/oncotarget.7702.

10.

IRE1α dissociates with BiP and inhibits ER stress-mediated apoptosis in cartilage development.

Han X, Zhou J, Zhang P, Song F, Jiang R, Li M, Xia F, Guo FJ.

Cell Signal. 2013 Nov;25(11):2136-46. doi: 10.1016/j.cellsig.2013.06.011.

PMID:
23816533
11.

BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth.

Yasui H, Hideshima T, Ikeda H, Jin J, Ocio EM, Kiziltepe T, Okawa Y, Vallet S, Podar K, Ishitsuka K, Richardson PG, Pargellis C, Moss N, Raje N, Anderson KC.

Br J Haematol. 2007 Feb;136(3):414-23.

PMID:
17173546
12.

Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma.

Leung-Hagesteijn C, Erdmann N, Cheung G, Keats JJ, Stewart AK, Reece DE, Chung KC, Tiedemann RE.

Cancer Cell. 2013 Sep 9;24(3):289-304. doi: 10.1016/j.ccr.2013.08.009. Erratum in: Cancer Cell. 2015 Oct 12;28(4):541-2.

13.

IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis.

Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, Toyama Y, Horiuchi K.

J Clin Invest. 2015 Aug 3;125(8):3269-79. doi: 10.1172/JCI76765.

14.

A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation.

Majumder M, Huang C, Snider MD, Komar AA, Tanaka J, Kaufman RJ, Krokowski D, Hatzoglou M.

Mol Cell Biol. 2012 Mar;32(5):992-1003. doi: 10.1128/MCB.06665-11.

15.

The molecular mechanisms of XBP-1 gene silencing on IRE1α-TRAF2-ASK1-JNK pathways in oral squamous cell carcinoma under endoplasmic reticulum stress.

Chen H, Yang H, Pan L, Wang W, Liu X, Ren X, Liu Y, Liu W, Zhang Y, Jiang L, Li K, Zhang B, Wang LX.

Biomed Pharmacother. 2016 Feb;77:108-13. doi: 10.1016/j.biopha.2015.12.010.

PMID:
26796273
16.

Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway.

Namba T, Chu K, Kodama R, Byun S, Yoon KW, Hiraki M, Mandinova A, Lee SW.

Oncotarget. 2015 Aug 21;6(24):19990-20001.

17.

The IRE1α-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis.

Tohmonda T, Yoda M, Mizuochi H, Morioka H, Matsumoto M, Urano F, Toyama Y, Horiuchi K.

J Biol Chem. 2013 Jan 18;288(3):1691-5. doi: 10.1074/jbc.C112.424606.

18.

Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1.

Ling SC, Lau EK, Al-Shabeeb A, Nikolic A, Catalano A, Iland H, Horvath N, Ho PJ, Harrison S, Fleming S, Joshua DE, Allen JD.

Haematologica. 2012 Jan;97(1):64-72. doi: 10.3324/haematol.2011.043331.

19.

Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues.

Zhang H, Nakajima S, Kato H, Gu L, Yoshitomi T, Nagai K, Shinmori H, Kokubo S, Kitamura M.

Br J Pharmacol. 2013 Oct;170(4):822-34. doi: 10.1111/bph.12306.

20.

Novel mechanism of enhancing IRE1α-XBP1 signalling via the PERK-ATF4 pathway.

Tsuru A, Imai Y, Saito M, Kohno K.

Sci Rep. 2016 Apr 7;6:24217. doi: 10.1038/srep24217.

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