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Items: 1 to 20 of 138


Base pairing between hepatitis C virus RNA and microRNA 122 3' of its seed sequence is essential for genome stabilization and production of infectious virus.

Shimakami T, Yamane D, Welsch C, Hensley L, Jangra RK, Lemon SM.

J Virol. 2012 Jul;86(13):7372-83. doi: 10.1128/JVI.00513-12.


Human Ago2 is required for efficient microRNA 122 regulation of hepatitis C virus RNA accumulation and translation.

Wilson JA, Zhang C, Huys A, Richardson CD.

J Virol. 2011 Mar;85(5):2342-50. doi: 10.1128/JVI.02046-10.


Regulation of hepatitis C virus translation and infectious virus production by the microRNA miR-122.

Jangra RK, Yi M, Lemon SM.

J Virol. 2010 Jul;84(13):6615-25. doi: 10.1128/JVI.00417-10.


MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR.

Li YP, Gottwein JM, Scheel TK, Jensen TB, Bukh J.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4991-6. doi: 10.1073/pnas.1016606108.


Regulation of Hepatitis C Virus Genome Replication by Xrn1 and MicroRNA-122 Binding to Individual Sites in the 5' Untranslated Region.

Thibault PA, Huys A, Amador-CaƱizares Y, Gailius JE, Pinel DE, Wilson JA.

J Virol. 2015 Jun;89(12):6294-311. doi: 10.1128/JVI.03631-14.


Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex.

Shimakami T, Yamane D, Jangra RK, Kempf BJ, Spaniel C, Barton DJ, Lemon SM.

Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):941-6. doi: 10.1073/pnas.1112263109.


A miRNA-responsive cell-free translation system facilitates isolation of hepatitis C virus miRNP complexes.

Bradrick SS, Nagyal S, Novatt H.

RNA. 2013 Aug;19(8):1159-69. doi: 10.1261/rna.038810.113.


Structural map of a microRNA-122: hepatitis C virus complex.

Pang PS, Pham EA, Elazar M, Patel SG, Eckart MR, Glenn JS.

J Virol. 2012 Jan;86(2):1250-4. doi: 10.1128/JVI.06367-11.


hnRNP L and NF90 interact with hepatitis C virus 5'-terminal untranslated RNA and promote efficient replication.

Li Y, Masaki T, Shimakami T, Lemon SM.

J Virol. 2014 Jul;88(13):7199-209. doi: 10.1128/JVI.00225-14.


Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure.

Mortimer SA, Doudna JA.

Nucleic Acids Res. 2013 Apr;41(7):4230-40. doi: 10.1093/nar/gkt075.


Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication.

Li Y, Masaki T, Yamane D, McGivern DR, Lemon SM.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1881-6. doi: 10.1073/pnas.1213515110.


A novel strategy to inhibit the reproduction and translation of hepatitis C virus.

Duan A, Ning L, Li C, Hou Y, Yang N, Sun L, Li G.

Sci China Life Sci. 2013 Apr;56(4):293-7. doi: 10.1007/s11427-013-4468-2.


MicroRNA-122 dependent binding of Ago2 protein to hepatitis C virus RNA is associated with enhanced RNA stability and translation stimulation.

Conrad KD, Giering F, Erfurth C, Neumann A, Fehr C, Meister G, Niepmann M.

PLoS One. 2013;8(2):e56272. doi: 10.1371/journal.pone.0056272. Erratum in: PLoS One. 2016;11(7):e0160132.


miR-122 and the Hepatitis C RNA genome: more than just stability.

Li Y, Masaki T, Lemon SM.

RNA Biol. 2013 Jun;10(6):919-23. doi: 10.4161/rna.25137.


Stimulation of Hepatitis C Virus RNA translation by microRNA-122 occurs under different conditions in vivo and in vitro.

Goergen D, Niepmann M.

Virus Res. 2012 Aug;167(2):343-52. doi: 10.1016/j.virusres.2012.05.022.


miR-122 stimulates hepatitis C virus RNA synthesis by altering the balance of viral RNAs engaged in replication versus translation.

Masaki T, Arend KC, Li Y, Yamane D, McGivern DR, Kato T, Wakita T, Moorman NJ, Lemon SM.

Cell Host Microbe. 2015 Feb 11;17(2):217-28. doi: 10.1016/j.chom.2014.12.014.


Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex.

Machlin ES, Sarnow P, Sagan SM.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3193-8. doi: 10.1073/pnas.1012464108.


Requirements for human Dicer and TRBP in microRNA-122 regulation of HCV translation and RNA abundance.

Zhang C, Huys A, Thibault PA, Wilson JA.

Virology. 2012 Nov 25;433(2):479-88. doi: 10.1016/j.virol.2012.08.039.


Hepatitis C virus subverts liver-specific miR-122 to protect the viral genome from exoribonuclease Xrn2.

Sedano CD, Sarnow P.

Cell Host Microbe. 2014 Aug 13;16(2):257-64. doi: 10.1016/j.chom.2014.07.006.


Modulation of hepatitis C virus RNA accumulation and translation by DDX6 and miR-122 are mediated by separate mechanisms.

Huys A, Thibault PA, Wilson JA.

PLoS One. 2013 Jun 24;8(6):e67437. doi: 10.1371/journal.pone.0067437.

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