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Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1β production from monocytes in humans.

Lee WW, Lee N, Fujii H, Kang I.

Cell Immunol. 2012 Jan-Feb;275(1-2):19-23. doi: 10.1016/j.cellimm.2012.04.001. Epub 2012 Apr 6.


The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1β, IL-23, and TNF-like 1A expression by monocytes.

Cunin P, Caillon A, Corvaisier M, Garo E, Scotet M, Blanchard S, Delneste Y, Jeannin P.

J Immunol. 2011 Apr 1;186(7):4175-82. doi: 10.4049/jimmunol.1002535. Epub 2011 Mar 2.


Interferon-α-conditioned human monocytes combine a Th1-orienting attitude with the induction of autologous Th17 responses: role of IL-23 and IL-12.

Santini SM, Lapenta C, Donati S, Spadaro F, Belardelli F, Ferrantini M.

PLoS One. 2011 Feb 28;6(2):e17364. doi: 10.1371/journal.pone.0017364.


Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity.

Kleinnijenhuis J, Quintin J, Preijers F, Benn CS, Joosten LA, Jacobs C, van Loenhout J, Xavier RJ, Aaby P, van der Meer JW, van Crevel R, Netea MG.

J Innate Immun. 2014;6(2):152-8. doi: 10.1159/000355628. Epub 2013 Oct 30.


Prostaglandin I(2) analogues enhance already exuberant Th17 cell responses in systemic sclerosis.

Truchetet ME, Allanore Y, Montanari E, Chizzolini C, Brembilla NC.

Ann Rheum Dis. 2012 Dec;71(12):2044-50. doi: 10.1136/annrheumdis-2012-201400. Epub 2012 Jul 19.


Inhibition of interleukin-1β-mediated interleukin-1 receptor-associated kinase 4 phosphorylation by zinc leads to repression of memory T helper type 17 response in humans.

Lee H, Kim B, Choi YH, Hwang Y, Kim DH, Cho S, Hong SJ, Lee WW.

Immunology. 2015 Dec;146(4):645-56. doi: 10.1111/imm.12536. Epub 2015 Oct 28.


Human monocytes promote Th1 and Th17 responses to Streptococcus pneumoniae.

Olliver M, Hiew J, Mellroth P, Henriques-Normark B, Bergman P.

Infect Immun. 2011 Oct;79(10):4210-7. doi: 10.1128/IAI.05286-11. Epub 2011 Jul 25.


TNFα promotes Th17 cell differentiation through IL-6 and IL-1β produced by monocytes in rheumatoid arthritis.

Zheng Y, Sun L, Jiang T, Zhang D, He D, Nie H.

J Immunol Res. 2014;2014:385352. doi: 10.1155/2014/385352. Epub 2014 Nov 11.


Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1- and Th-17-polarizing capability.

Dzopalic T, Dragicevic A, Vasilijic S, Vucevic D, Majstorovic I, Bozic B, Balint B, Colic M.

Int Immunopharmacol. 2010 Nov;10(11):1428-33. doi: 10.1016/j.intimp.2010.08.010. Epub 2010 Sep 15.


Th17 cells induce Th1-polarizing monocyte-derived dendritic cells.

Davidson MG, Alonso MN, Yuan R, Axtell RC, Kenkel JA, Suhoski MM, González JC, Steinman L, Engleman EG.

J Immunol. 2013 Aug 1;191(3):1175-87. doi: 10.4049/jimmunol.1203201. Epub 2013 Jun 21.


Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15.

Gov L, Karimzadeh A, Ueno N, Lodoen MB.

MBio. 2013 Jul 9;4(4). pii: e00255-13. doi: 10.1128/mBio.00255-13.


TGF-β enhanced IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3.

Liu Y, Yu S, Li Z, Ma J, Zhang Y, Wang H, Yang B, Wu C.

PLoS One. 2013 May 31;8(5):e64612. doi: 10.1371/journal.pone.0064612. Print 2013.


Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production.

Feng T, Qin H, Wang L, Benveniste EN, Elson CO, Cong Y.

J Immunol. 2011 Jun 1;186(11):6313-8. doi: 10.4049/jimmunol.1001454. Epub 2011 Apr 29.


Differences in T-helper polarizing capability between human monocyte-derived dendritic cells and monocyte-derived Langerhans'-like cells.

Rajkovic I, Dragicevic A, Vasilijic S, Bozic B, Dzopalic T, Tomic S, Majstorovic I, Vucevic D, Djokic J, Balint B, Colic M.

Immunology. 2011 Feb;132(2):217-25. doi: 10.1111/j.1365-2567.2010.03356.x. Epub 2010 Oct 13.


Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes.

Garcia-Mauriño S, Gonzalez-Haba MG, Calvo JR, Rafii-El-Idrissi M, Sanchez-Margalet V, Goberna R, Guerrero JM.

J Immunol. 1997 Jul 15;159(2):574-81.


Early secreted antigenic target of 6-kDa protein of Mycobacterium tuberculosis primes dendritic cells to stimulate Th17 and inhibit Th1 immune responses.

Wang X, Barnes PF, Huang F, Alvarez IB, Neuenschwander PF, Sherman DR, Samten B.

J Immunol. 2012 Sep 15;189(6):3092-103. doi: 10.4049/jimmunol.1200573. Epub 2012 Aug 17.


IL-1β promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes.

Duhen T, Campbell DJ.

J Immunol. 2014 Jul 1;193(1):120-9. doi: 10.4049/jimmunol.1302734. Epub 2014 Jun 2.


A novel human truncated IL12rβ1-Fc fusion protein ameliorates experimental autoimmune encephalomyelitis via specific binding of p40 to inhibit Th1 and Th17 cell differentiation.

Guo W, Wang C, Wang X, Luo C, Yu D, Wang Y, Chen Y, Lei W, Gao X, Yao W.

Oncotarget. 2015 Oct 6;6(30):28539-55. doi: 10.18632/oncotarget.5164.


IL-12 inhibits the TGF-β-dependent T cell developmental programs and skews the TGF-β-induced differentiation into a Th1-like direction.

Prochazkova J, Pokorna K, Holan V.

Immunobiology. 2012 Jan;217(1):74-82. doi: 10.1016/j.imbio.2011.07.032. Epub 2011 Aug 5.


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