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Items: 1 to 20 of 88


Spine degeneration in a murine model of chronic human tobacco smokers.

Wang D, Nasto LA, Roughley P, Leme AS, Houghton AM, Usas A, Sowa G, Lee J, Niedernhofer L, Shapiro S, Kang J, Vo N.

Osteoarthritis Cartilage. 2012 Aug;20(8):896-905. doi: 10.1016/j.joca.2012.04.010. Epub 2012 Apr 21.


Investigating the role of DNA damage in tobacco smoking-induced spine degeneration.

Nasto LA, Ngo K, Leme AS, Robinson AR, Dong Q, Roughley P, Usas A, Sowa GA, Pola E, Kang J, Niedernhofer LJ, Shapiro S, Vo NV.

Spine J. 2014 Mar 1;14(3):416-23. doi: 10.1016/j.spinee.2013.08.034. Epub 2013 Nov 6.


ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration.

Ngo K, Pohl P, Wang D, Leme AS, Lee J, Di P, Roughley P, Robbins PD, Niedernhofer LJ, Sowa G, Kang JD, Shapiro SS, Vo NV.

Spine (Phila Pa 1976). 2017 Oct 15;42(20):1521-1528. doi: 10.1097/BRS.0000000000002258.


Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs.

Nasto LA, Wang D, Robinson AR, Clauson CL, Ngo K, Dong Q, Roughley P, Epperly M, Huq SM, Pola E, Sowa G, Robbins PD, Kang J, Niedernhofer LJ, Vo NV.

Mech Ageing Dev. 2013 Jan-Feb;134(1-2):35-42. doi: 10.1016/j.mad.2012.11.002. Epub 2012 Dec 19.


Accelerated aging of intervertebral discs in a mouse model of progeria.

Vo N, Seo HY, Robinson A, Sowa G, Bentley D, Taylor L, Studer R, Usas A, Huard J, Alber S, Watkins SC, Lee J, Coehlo P, Wang D, Loppini M, Robbins PD, Niedernhofer LJ, Kang J.

J Orthop Res. 2010 Dec;28(12):1600-7. doi: 10.1002/jor.21153.


ISSLS prize winner: inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging.

Nasto LA, Seo HY, Robinson AR, Tilstra JS, Clauson CL, Sowa GA, Ngo K, Dong Q, Pola E, Lee JY, Niedernhofer LJ, Kang JD, Robbins PD, Vo NV.

Spine (Phila Pa 1976). 2012 Oct 1;37(21):1819-25. Erratum in: Spine (Phila Pa 1976). 2013 Jan 1;38(1):E48.


Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats.

Luo Y, Zhang L, Wang WY, Hu QF, Song HP, Su YL, Zhang YZ.

Bone. 2013 Aug;55(2):439-48. doi: 10.1016/j.bone.2013.03.002. Epub 2013 Mar 14.


Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration.

Melrose J, Shu C, Young C, Ho R, Smith MM, Young AA, Smith SS, Gooden B, Dart A, Podadera J, Appleyard RC, Little CB.

Spine (Phila Pa 1976). 2012 Jan 1;37(1):18-25. doi: 10.1097/BRS.0b013e31820cd8d5.


Differential effects of nicotine and tobacco smoke condensate on human annulus fibrosus cell metabolism.

Vo N, Wang D, Sowa G, Witt W, Ngo K, Coelho P, Bedison R, Byer B, Studer R, Lee J, Di YP, Kang J.

J Orthop Res. 2011 Oct;29(10):1585-91. doi: 10.1002/jor.21417. Epub 2011 Mar 29.


Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration.

Yurube T, Takada T, Suzuki T, Kakutani K, Maeno K, Doita M, Kurosaka M, Nishida K.

Arthritis Res Ther. 2012 Mar 6;14(2):R51. doi: 10.1186/ar3764.


[Experimental study on lumbar intervetebral disc degeneration model with kidney deficiency by ovariectomizing].

Yao CF, Zhao YJ, Niu K, Sun YL, Li CG, Tang DZ, Shu B, Lu S, Zhou CJ, Liang QQ, Shi Q, Wang YJ.

Zhongguo Gu Shang. 2013 Dec;26(12):1015-22. Chinese.


Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.

Little CB, Hughes CE, Curtis CL, Janusz MJ, Bohne R, Wang-Weigand S, Taiwo YO, Mitchell PG, Otterness IG, Flannery CR, Caterson B.

Matrix Biol. 2002 Apr;21(3):271-88.


Structure, function, aging and turnover of aggrecan in the intervertebral disc.

Sivan SS, Wachtel E, Roughley P.

Biochim Biophys Acta. 2014 Oct;1840(10):3181-9. doi: 10.1016/j.bbagen.2014.07.013. Epub 2014 Jul 24. Review.


Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system.

Wang D, Vo NV, Sowa GA, Hartman RA, Ngo K, Choe SR, Witt WT, Dong Q, Lee JY, Niedernhofer LJ, Kang JD.

Spine J. 2011 Feb;11(2):139-46. doi: 10.1016/j.spinee.2010.11.017.


Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration.

Nasto LA, Robinson AR, Ngo K, Clauson CL, Dong Q, St Croix C, Sowa G, Pola E, Robbins PD, Kang J, Niedernhofer LJ, Wipf P, Vo NV.

J Orthop Res. 2013 Jul;31(7):1150-7. doi: 10.1002/jor.22320. Epub 2013 Feb 6.


The effect of bone morphogenetic protein-2 on rat intervertebral disc cells in vitro.

Tim Yoon S, Su Kim K, Li J, Soo Park J, Akamaru T, Elmer WA, Hutton WC.

Spine (Phila Pa 1976). 2003 Aug 15;28(16):1773-80.


Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study.

Lotz JC, Colliou OK, Chin JR, Duncan NA, Liebenberg E.

Spine (Phila Pa 1976). 1998 Dec 1;23(23):2493-506.


Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral disc degeneration.

Jiang L, Zhang X, Zheng X, Ru A, Ni X, Wu Y, Tian N, Huang Y, Xue E, Wang X, Xu H.

J Orthop Res. 2013 May;31(5):692-702. doi: 10.1002/jor.22289. Epub 2012 Dec 13.


Potential use of human adipose mesenchymal stromal cells for intervertebral disc regeneration: a preliminary study on biglycan-deficient murine model of chronic disc degeneration.

Marfia G, Campanella R, Navone SE, Zucca I, Scotti A, Figini M, Di Vito C, Alessandri G, Riboni L, Parati E.

Arthritis Res Ther. 2014 Oct 8;16(5):457. doi: 10.1186/s13075-014-0457-5.


Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration.

Patel KP, Sandy JD, Akeda K, Miyamoto K, Chujo T, An HS, Masuda K.

Spine (Phila Pa 1976). 2007 Nov 1;32(23):2596-603.


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