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Items: 1 to 20 of 130

1.

An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases.

Bailey D, Carpenter EP, Coker A, Coker S, Read J, Jones AT, Erskine P, Aguilar CF, Badasso M, Toldo L, Rippmann F, Sanz-Aparicio J, Albert A, Blundell TL, Roberts NB, Wood SP, Cooper JB.

Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):541-52. doi: 10.1107/S0907444912004817. Epub 2012 Apr 17.

PMID:
22525752
2.

Domain flexibility in aspartic proteinases.

Sali A, Veerapandian B, Cooper JB, Moss DS, Hofmann T, Blundell TL.

Proteins. 1992 Feb;12(2):158-70.

PMID:
1603805
3.
4.

Design and synthesis of unsymmetrical peptidyl urea inhibitors of aspartic peptidases.

Dales NA, Bohacek RS, Satyshur KA, Rich DH.

Org Lett. 2001 Jul 26;3(15):2313-6.

PMID:
11463304
5.

Five atomic resolution structures of endothiapepsin inhibitor complexes: implications for the aspartic proteinase mechanism.

Coates L, Erskine PT, Crump MP, Wood SP, Cooper JB.

J Mol Biol. 2002 May 17;318(5):1405-15.

PMID:
12083527
6.

The structure of endothiapepsin complexed with a Phe-Tyr reduced-bond inhibitor at 1.35 Å resolution.

Guo J, Cooper JB, Wood SP.

Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):30-3. doi: 10.1107/S2053230X13032974. Epub 2013 Dec 24.

7.

Revised 2.3 A structure of porcine pepsin: evidence for a flexible subdomain.

Abad-Zapatero C, Rydel TJ, Erickson J.

Proteins. 1990;8(1):62-81.

PMID:
2217165
8.

On the orientation of the catalytic dyad in aspartic proteases.

Friedman R, Caflisch A.

Proteins. 2010 May 1;78(6):1575-82. doi: 10.1002/prot.22674.

PMID:
20112416
9.

Crystal structure of aspartic proteinase from Irpex lacteus in complex with inhibitor pepstatin.

Fujimoto Z, Fujii Y, Kaneko S, Kobayashi H, Mizuno H.

J Mol Biol. 2004 Aug 27;341(5):1227-35.

PMID:
15321718
10.

The three-dimensional structure at 2.4 A resolution of glycosylated proteinase A from the lysosome-like vacuole of Saccharomyces cerevisiae.

Aguilar CF, Cronin NB, Badasso M, Dreyer T, Newman MP, Cooper JB, Hoover DJ, Wood SP, Johnson MS, Blundell TL.

J Mol Biol. 1997 Apr 11;267(4):899-915.

PMID:
9135120
11.

Aspartic proteases in drug discovery.

Eder J, Hommel U, Cumin F, Martoglio B, Gerhartz B.

Curr Pharm Des. 2007;13(3):271-85. Review.

PMID:
17313361
12.

X-ray, neutron and NMR studies of the catalytic mechanism of aspartic proteinases.

Coates L, Erskine PT, Mall S, Gill R, Wood SP, Myles DA, Cooper JB.

Eur Biophys J. 2006 Sep;35(7):559-66. Epub 2006 May 4.

PMID:
16673078
13.

Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.

Hartman AM, Mondal M, Radeva N, Klebe G, Hirsch AK.

Int J Mol Sci. 2015 Aug 14;16(8):19184-94. doi: 10.3390/ijms160819184.

14.
15.

Statistical coupling analysis of aspartic proteinases based on crystal structures of the Trichoderma reesei enzyme and its complex with pepstatin A.

Nascimento AS, Krauchenco S, Golubev AM, Gustchina A, Wlodawer A, Polikarpov I.

J Mol Biol. 2008 Oct 10;382(3):763-78. doi: 10.1016/j.jmb.2008.07.043. Epub 2008 Jul 22.

16.

Replacement of isobutyl by trifluoromethyl in pepstatin A selectively affects inhibition of aspartic proteinases.

Binkert C, Frigerio M, Jones A, Meyer S, Pesenti C, Prade L, Viani F, Zanda M.

Chembiochem. 2006 Jan;7(1):181-6.

PMID:
16307463
17.

X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0 A resolution of the aspartic proteinase from Mucor pusillus.

Newman M, Watson F, Roychowdhury P, Jones H, Badasso M, Cleasby A, Wood SP, Tickle IJ, Blundell TL.

J Mol Biol. 1993 Mar 5;230(1):260-83.

PMID:
8450540
18.
19.

Thermodynamic mapping of the inhibitor site of the aspartic protease endothiapepsin.

Gómez J, Freire E.

J Mol Biol. 1995 Sep 22;252(3):337-50.

PMID:
7563055
20.

Crystal structure of scytalidoglutamic peptidase with its first potent inhibitor provides insights into substrate specificity and catalysis.

Pillai B, Cherney MM, Hiraga K, Takada K, Oda K, James MN.

J Mol Biol. 2007 Jan 12;365(2):343-61. Epub 2006 Sep 27.

PMID:
17069854

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