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Items: 1 to 20 of 94

1.

PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques.

Dyavar Shetty R, Velu V, Titanji K, Bosinger SE, Freeman GJ, Silvestri G, Amara RR.

J Clin Invest. 2012 May;122(5):1712-6. doi: 10.1172/JCI60612. Epub 2012 Apr 23.

2.

Enhancing immune responses to limit chronic immune activation during SIV.

Estes JD.

J Clin Invest. 2012 May;122(5):1611-4. doi: 10.1172/JCI63389. Epub 2012 Apr 23.

3.

Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination.

Velu V, Kannanganat S, Ibegbu C, Chennareddi L, Villinger F, Freeman GJ, Ahmed R, Amara RR.

J Virol. 2007 Jun;81(11):5819-28. Epub 2007 Mar 21.

4.

Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21.

Pallikkuth S, Micci L, Ende ZS, Iriele RI, Cervasi B, Lawson B, McGary CS, Rogers KA, Else JG, Silvestri G, Easley K, Estes JD, Villinger F, Pahwa S, Paiardini M.

PLoS Pathog. 2013;9(7):e1003471. doi: 10.1371/journal.ppat.1003471. Epub 2013 Jul 4.

5.

In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit.

Amancha PK, Hong JJ, Rogers K, Ansari AA, Villinger F.

J Immunol. 2013 Dec 15;191(12):6060-70. doi: 10.4049/jimmunol.1302044. Epub 2013 Nov 13.

7.

Loss of IL-17-producing CD8 T cells during late chronic stage of pathogenic simian immunodeficiency virus infection.

Nigam P, Kwa S, Velu V, Amara RR.

J Immunol. 2011 Jan 15;186(2):745-53. doi: 10.4049/jimmunol.1002807. Epub 2010 Dec 10.

8.

Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation.

Vanderford TH, Slichter C, Rogers KA, Lawson BO, Obaede R, Else J, Villinger F, Bosinger SE, Silvestri G.

Blood. 2012 Jun 14;119(24):5750-7. doi: 10.1182/blood-2012-02-411496. Epub 2012 May 1.

9.

Microbial translocation in the pathogenesis of HIV infection and AIDS.

Marchetti G, Tincati C, Silvestri G.

Clin Microbiol Rev. 2013 Jan;26(1):2-18. doi: 10.1128/CMR.00050-12. Review.

10.

Microbial translocation in simian immunodeficiency virus (SIV)-infected rhesus monkeys (Macaca mulatta).

Leinert C, Stahl-Hennig C, Ecker A, Schneider T, Fuchs D, Sauermann U, Sopper S.

J Med Primatol. 2010 Aug;39(4):243-51. doi: 10.1111/j.1600-0684.2010.00429.x.

PMID:
20618590
11.

Enhancing SIV-specific immunity in vivo by PD-1 blockade.

Velu V, Titanji K, Zhu B, Husain S, Pladevega A, Lai L, Vanderford TH, Chennareddi L, Silvestri G, Freeman GJ, Ahmed R, Amara RR.

Nature. 2009 Mar 12;458(7235):206-10. doi: 10.1038/nature07662. Epub 2008 Dec 10.

13.

Expansion of FOXP3+ CD8 T cells with suppressive potential in colorectal mucosa following a pathogenic simian immunodeficiency virus infection correlates with diminished antiviral T cell response and viral control.

Nigam P, Velu V, Kannanganat S, Chennareddi L, Kwa S, Siddiqui M, Amara RR.

J Immunol. 2010 Feb 15;184(4):1690-701. doi: 10.4049/jimmunol.0902955. Epub 2010 Jan 6.

14.

Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques.

Metzner KJ, Binley JM, Gettie A, Marx P, Nixon DF, Connor RI.

Retrovirology. 2006 Dec 21;3:97.

16.

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression.

Sandler NG, Bosinger SE, Estes JD, Zhu RT, Tharp GK, Boritz E, Levin D, Wijeyesinghe S, Makamdop KN, del Prete GQ, Hill BJ, Timmer JK, Reiss E, Yarden G, Darko S, Contijoch E, Todd JP, Silvestri G, Nason M, Norgren RB Jr, Keele BF, Rao S, Langer JA, Lifson JD, Schreiber G, Douek DC.

Nature. 2014 Jul 31;511(7511):601-5. doi: 10.1038/nature13554. Epub 2014 Jul 9.

17.

Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression.

Xu H, Wang X, Pahar B, Moroney-Rasmussen T, Alvarez X, Lackner AA, Veazey RS.

J Immunol. 2010 Dec 15;185(12):7340-8. doi: 10.4049/jimmunol.1001642. Epub 2010 Nov 8.

18.

Soluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection.

Onlamoon N, Rogers K, Mayne AE, Pattanapanyasat K, Mori K, Villinger F, Ansari AA.

Immunology. 2008 Jun;124(2):277-93. doi: 10.1111/j.1365-2567.2007.02766.x. Epub 2008 Feb 5.

19.

Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1.

Salisch NC, Kaufmann DE, Awad AS, Reeves RK, Tighe DP, Li Y, Piatak M Jr, Lifson JD, Evans DT, Pereyra F, Freeman GJ, Johnson RP.

J Immunol. 2010 Jan 1;184(1):476-87. doi: 10.4049/jimmunol.0902781. Epub 2009 Nov 30.

20.

Immunological and virological studies of natural SIV infection of disease-resistant nonhuman primates.

Villinger F, Folks TM, Lauro S, Powell JD, Sundstrom JB, Mayne A, Ansari AA.

Immunol Lett. 1996 Jun;51(1-2):59-68.

PMID:
8811346

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