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Items: 1 to 20 of 138

1.

Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma.

Hwang S, Maloney NS, Bruinsma MW, Goel G, Duan E, Zhang L, Shrestha B, Diamond MS, Dani A, Sosnovtsev SV, Green KY, Lopez-Otin C, Xavier RJ, Thackray LB, Virgin HW.

Cell Host Microbe. 2012 Apr 19;11(4):397-409. doi: 10.1016/j.chom.2012.03.002.

2.

Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex.

Ishibashi K, Fujita N, Kanno E, Omori H, Yoshimori T, Itoh T, Fukuda M.

Autophagy. 2011 Dec;7(12):1500-13.

3.

Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation.

Walczak M, Martens S.

Autophagy. 2013 Mar;9(3):424-5. doi: 10.4161/auto.22931. Epub 2013 Jan 15.

4.

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.

Kimmey JM, Huynh JP, Weiss LA, Park S, Kambal A, Debnath J, Virgin HW, Stallings CL.

Nature. 2015 Dec 24;528(7583):565-9. doi: 10.1038/nature16451. Epub 2015 Dec 9.

5.

Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation.

Romanov J, Walczak M, Ibiricu I, Schüchner S, Ogris E, Kraft C, Martens S.

EMBO J. 2012 Nov 14;31(22):4304-17. doi: 10.1038/emboj.2012.278. Epub 2012 Oct 12.

6.

Interaction of caveolin-1 with ATG12-ATG5 system suppresses autophagy in lung epithelial cells.

Chen ZH, Cao JF, Zhou JS, Liu H, Che LQ, Mizumura K, Li W, Choi AM, Shen HH.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L1016-25. doi: 10.1152/ajplung.00268.2013. Epub 2014 Apr 11.

7.

Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii.

Ohshima J, Lee Y, Sasai M, Saitoh T, Su Ma J, Kamiyama N, Matsuura Y, Pann-Ghill S, Hayashi M, Ebisu S, Takeda K, Akira S, Yamamoto M.

J Immunol. 2014 Apr 1;192(7):3328-35. doi: 10.4049/jimmunol.1302822. Epub 2014 Feb 21.

8.

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.

Otomo C, Metlagel Z, Takaesu G, Otomo T.

Nat Struct Mol Biol. 2013 Jan;20(1):59-66. doi: 10.1038/nsmb.2431. Epub 2012 Dec 2.

9.

ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation.

Song H, Pu J, Wang L, Wu L, Xiao J, Liu Q, Chen J, Zhang M, Liu Y, Ni M, Mo J, Zheng Y, Wan D, Cai X, Cao Y, Xiao W, Ye L, Tu E, Lin Z, Wen J, Lu X, He J, Peng Y, Su J, Zhang H, Zhao Y, Lin M, Zhang Z.

Autophagy. 2015;11(8):1308-25. doi: 10.1080/15548627.2015.1060386.

10.

WIPI2B links PtdIns3P to LC3 lipidation through binding ATG16L1.

Dooley HC, Wilson MI, Tooze SA.

Autophagy. 2015;11(1):190-1. doi: 10.1080/15548627.2014.996029.

11.

Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners.

Kim JH, Hong SB, Lee JK, Han S, Roh KH, Lee KE, Kim YK, Choi EJ, Song HK.

Autophagy. 2015;11(1):75-87. doi: 10.4161/15548627.2014.984276.

12.

Dynamics of Atg5-Atg12-Atg16L1 Aggregation and Deaggregation.

Kharaziha P, Panaretakis T.

Methods Enzymol. 2017;587:247-255. doi: 10.1016/bs.mie.2016.09.059. Epub 2016 Dec 3.

PMID:
28253959
13.

WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.

Dooley HC, Razi M, Polson HE, Girardin SE, Wilson MI, Tooze SA.

Mol Cell. 2014 Jul 17;55(2):238-52. doi: 10.1016/j.molcel.2014.05.021. Epub 2014 Jun 19.

14.

The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.

Choi J, Park S, Biering SB, Selleck E, Liu CY, Zhang X, Fujita N, Saitoh T, Akira S, Yoshimori T, Sibley LD, Hwang S, Virgin HW.

Immunity. 2014 Jun 19;40(6):924-35. doi: 10.1016/j.immuni.2014.05.006. Epub 2014 Jun 12.

15.

The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.

Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguère PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, Chen X, Ting JP.

Immunity. 2012 Jun 29;36(6):933-46. doi: 10.1016/j.immuni.2012.03.025.

16.

The Atg5 Atg12 conjugate associates with innate antiviral immune responses.

Jounai N, Takeshita F, Kobiyama K, Sawano A, Miyawaki A, Xin KQ, Ishii KJ, Kawai T, Akira S, Suzuki K, Okuda K.

Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14050-5. Epub 2007 Aug 20.

17.

Rab33B and its autophagic Atg5/12/16L1 effector assist in hepatitis B virus naked capsid formation and release.

Döring T, Prange R.

Cell Microbiol. 2015 May;17(5):747-64. doi: 10.1111/cmi.12398. Epub 2015 Jan 24.

PMID:
25439980
18.

Structure of the Atg12-Atg5 conjugate reveals a platform for stimulating Atg8-PE conjugation.

Noda NN, Fujioka Y, Hanada T, Ohsumi Y, Inagaki F.

EMBO Rep. 2013 Feb;14(2):206-11. doi: 10.1038/embor.2012.208. Epub 2012 Dec 14.

19.

A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate.

Chen D, Fan W, Lu Y, Ding X, Chen S, Zhong Q.

Mol Cell. 2012 Mar 9;45(5):629-41. doi: 10.1016/j.molcel.2011.12.036. Epub 2012 Feb 16.

20.

Vaccinia virus leads to ATG12–ATG3 conjugation and deficiency in autophagosome formation.

Moloughney JG, Monken CE, Tao H, Zhang H, Thomas JD, Lattime EC, Jin S.

Autophagy. 2011 Dec;7(12):1434-47.

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