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Items: 1 to 20 of 87

1.

Memory deficits of British dementia knock-in mice are prevented by Aβ-precursor protein haploinsufficiency.

Tamayev R, D'Adamio L.

J Neurosci. 2012 Apr 18;32(16):5481-5. doi: 10.1523/JNEUROSCI.5193-11.2012.

2.

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant.

Tamayev R, Matsuda S, Giliberto L, Arancio O, D'Adamio L.

EMBO J. 2011 May 17;30(12):2501-9. doi: 10.1038/emboj.2011.161.

3.

Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.

Tamayev R, Giliberto L, Li W, d'Abramo C, Arancio O, Vidal R, D'Adamio L.

J Neurosci. 2010 Nov 3;30(44):14915-24. doi: 10.1523/JNEUROSCI.3917-10.2010.

4.

Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory.

Biundo F, Ishiwari K, Del Prete D, D'Adamio L.

Neurobiol Learn Mem. 2015 Dec;126:18-30. doi: 10.1016/j.nlm.2015.10.009.

5.

Role of BRI2 in dementia.

Del Campo M, Teunissen CE.

J Alzheimers Dis. 2014;40(3):481-94. doi: 10.3233/JAD-131364. Review.

PMID:
24473189
6.

Increased AβPP processing in familial Danish dementia patients.

Matsuda S, Tamayev R, D'Adamio L.

J Alzheimers Dis. 2011;27(2):385-91. doi: 10.3233/JAD-2011-110785.

7.

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia.

Tamayev R, D'Adamio L.

Mol Neurodegener. 2012 Apr 26;7:19. doi: 10.1186/1750-1326-7-19.

8.

Lessons from a Rare Familial Dementia: Amyloid and Beyond.

Cantlon A, Frigerio CS, Walsh DM.

J Parkinsons Dis Alzheimers Dis. 2015 Aug;2(1). pii: 12.

9.

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.

Tamayev R, Akpan N, Arancio O, Troy CM, D'Adamio L.

Mol Neurodegener. 2012 Dec 10;7:60. doi: 10.1186/1750-1326-7-60.

10.

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia.

Tamayev R, Matsuda S, Arancio O, D'Adamio L.

EMBO Mol Med. 2012 Mar;4(3):171-9. doi: 10.1002/emmm.201100195.

11.

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits.

Tamayev R, Matsuda S, Fà M, Arancio O, D'Adamio L.

Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20822-7. doi: 10.1073/pnas.1011689107.

12.

Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia.

Biundo F, Ishiwari K, Del Prete D, D'Adamio L.

Oncotarget. 2016 Mar 15;7(11):11923-44. doi: 10.18632/oncotarget.7389.

13.

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J.

J Neurosci. 2005 Jul 20;25(29):6755-64.

14.

BRI2 (ITM2b) inhibits Abeta deposition in vivo.

Kim J, Miller VM, Levites Y, West KJ, Zwizinski CW, Moore BD, Troendle FJ, Bann M, Verbeeck C, Price RW, Smithson L, Sonoda L, Wagg K, Rangachari V, Zou F, Younkin SG, Graff-Radford N, Dickson D, Rosenberry T, Golde TE.

J Neurosci. 2008 Jun 4;28(23):6030-6. doi: 10.1523/JNEUROSCI.0891-08.2008.

15.

Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease.

Lashley T, Revesz T, Plant G, Bandopadhyay R, Lees AJ, Frangione B, Wood NW, de Silva R, Ghiso J, Rostagno A, Holton JL.

Neuropathol Appl Neurobiol. 2008 Oct;34(5):492-505. doi: 10.1111/j.1365-2990.2008.00935.x.

16.

Normal cognition in transgenic BRI2-Aβ mice.

Kim J, Chakrabarty P, Hanna A, March A, Dickson DW, Borchelt DR, Golde T, Janus C.

Mol Neurodegener. 2013 May 12;8:15. doi: 10.1186/1750-1326-8-15.

17.

BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).

Kilger E, Buehler A, Woelfing H, Kumar S, Kaeser SA, Nagarathinam A, Walter J, Jucker M, Coomaraswamy J.

J Biol Chem. 2011 Oct 28;286(43):37446-57. doi: 10.1074/jbc.M111.288373.

18.

An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss.

Lombino F, Biundo F, Tamayev R, Arancio O, D'Adamio L.

PLoS One. 2013;8(2):e57120. doi: 10.1371/journal.pone.0057120.

19.

BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.

Matsuda S, Giliberto L, Matsuda Y, McGowan EM, D'Adamio L.

J Neurosci. 2008 Aug 27;28(35):8668-76. doi: 10.1523/JNEUROSCI.2094-08.2008.

20.

Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia.

Marcora MS, Fernández-Gamba AC, Avendaño LA, Rotondaro C, Podhajcer OL, Vidal R, Morelli L, Ceriani MF, Castaño EM.

Mol Neurodegener. 2014 Jan 9;9:5. doi: 10.1186/1750-1326-9-5.

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