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Items: 1 to 20 of 101

1.

Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.

Keller MC, Simonson MA, Ripke S, Neale BM, Gejman PV, Howrigan DP, Lee SH, Lencz T, Levinson DF, Sullivan PF; Schizophrenia Psychiatric Genome-Wide Association Study Consortium.

PLoS Genet. 2012;8(4):e1002656. doi: 10.1371/journal.pgen.1002656. Epub 2012 Apr 12.

2.

Genome-wide autozygosity is associated with lower general cognitive ability.

Howrigan DP, Simonson MA, Davies G, Harris SE, Tenesa A, Starr JM, Liewald DC, Deary IJ, McRae A, Wright MJ, Montgomery GW, Hansell N, Martin NG, Payton A, Horan M, Ollier WE, Abdellaoui A, Boomsma DI, DeRosse P, Knowles EE, Glahn DC, Djurovic S, Melle I, Andreassen OA, Christoforou A, Steen VM, Hellard SL, Sundet K, Reinvang I, Espeseth T, Lundervold AJ, Giegling I, Konte B, Hartmann AM, Rujescu D, Roussos P, Giakoumaki S, Burdick KE, Bitsios P, Donohoe G, Corley RP, Visscher PM, Pendleton N, Malhotra AK, Neale BM, Lencz T, Keller MC.

Mol Psychiatry. 2016 Jun;21(6):837-43. doi: 10.1038/mp.2015.120. Epub 2015 Sep 22.

3.

Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia.

Lencz T, Lambert C, DeRosse P, Burdick KE, Morgan TV, Kane JM, Kucherlapati R, Malhotra AK.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19942-7. Epub 2007 Dec 5.

4.

Relationships between estimated autozygosity and complex traits in the UK Biobank.

Johnson EC, Evans LM, Keller MC.

PLoS Genet. 2018 Jul 27;14(7):e1007556. doi: 10.1371/journal.pgen.1007556. eCollection 2018 Jul.

5.

No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.

Johnson EC, Bjelland DW, Howrigan DP, Abdellaoui A, Breen G, Borglum A, Cichon S, Degenhardt F, Forstner AJ, Frank J, Genovese G, Heilmann-Heimbach S, Herms S, Hoffman P, Maier W, Mattheisen M, Morris D, Mowry B, Müller-Mhysok B, Neale B, Nenadic I, Nöthen MM, O'Dushlaine C, Rietschel M, Ruderfer DM, Rujescu D, Schulze TG, Simonson MA, Stahl E, Strohmaier J, Witt SH; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Sullivan PF, Keller MC.

PLoS Genet. 2016 Oct 28;12(10):e1006343. doi: 10.1371/journal.pgen.1006343. eCollection 2016 Oct.

6.

No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia.

Ruderfer DM, Lim ET, Genovese G, Moran JL, Hultman CM, Sullivan PF, McCarroll SA, Holmans P, Sklar P, Purcell SM.

Eur J Hum Genet. 2015 Apr;23(4):555-7. doi: 10.1038/ejhg.2014.228. Epub 2014 Nov 5.

7.

Runs of homozygosity in European populations.

McQuillan R, Leutenegger AL, Abdel-Rahman R, Franklin CS, Pericic M, Barac-Lauc L, Smolej-Narancic N, Janicijevic B, Polasek O, Tenesa A, Macleod AK, Farrington SM, Rudan P, Hayward C, Vitart V, Rudan I, Wild SH, Dunlop MG, Wright AF, Campbell H, Wilson JF.

Am J Hum Genet. 2008 Sep;83(3):359-72. doi: 10.1016/j.ajhg.2008.08.007. Epub 2008 Aug 28. Erratum in: Am J Hum Genet. 2008 Nov;83(5):658.

8.

No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset.

Heron EA, Cormican P, Donohoe G, O'Neill FA, Kendler KS, Riley BP; Wellcome Trust Case Control Consortium 2, Gill M, Corvin AP, Morris DW.

Schizophr Res. 2014 Apr;154(1-3):79-82. doi: 10.1016/j.schres.2014.01.038. Epub 2014 Feb 20.

9.

Genome-wide autozygosity mapping in human populations.

Wang S, Haynes C, Barany F, Ott J.

Genet Epidemiol. 2009 Feb;33(2):172-80. doi: 10.1002/gepi.20344.

10.

Exome sequencing in schizophrenic patients with high levels of homozygosity identifies novel and extremely rare mutations in the GABA/glutamatergic pathways.

Giacopuzzi E, Gennarelli M, Minelli A, Gardella R, Valsecchi P, Traversa M, Bonvicini C, Vita A, Sacchetti E, Magri C.

PLoS One. 2017 Aug 7;12(8):e0182778. doi: 10.1371/journal.pone.0182778. eCollection 2017.

11.

Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's disease.

Simón-Sánchez J, Kilarski LL, Nalls MA, Martinez M, Schulte C, Holmans P; International Parkinson's Disease Genomics Consortium; Wellcome Trust Case Control Consortium, Gasser T, Hardy J, Singleton AB, Wood NW, Brice A, Heutink P, Williams N, Morris HR.

PLoS One. 2012;7(3):e28787. doi: 10.1371/journal.pone.0028787. Epub 2012 Mar 12.

12.

Homozygosity mapping in an Irish ALS case-control cohort describes local demographic phenomena and points towards potential recessive risk loci.

McLaughlin RL, Kenna KP, Vajda A, Heverin M, Byrne S, Donaghy CG, Cronin S, Bradley DG, Hardiman O.

Genomics. 2015 Apr;105(4):237-41. doi: 10.1016/j.ygeno.2015.01.002. Epub 2015 Jan 23.

13.

Estimating autozygosity from high-throughput information: effects of SNP density and genotyping errors.

Ferenčaković M, Sölkner J, Curik I.

Genet Sel Evol. 2013 Oct 29;45:42. doi: 10.1186/1297-9686-45-42.

14.

The Relationship between Runs of Homozygosity and Inbreeding in Jersey Cattle under Selection.

Kim ES, Sonstegard TS, Van Tassell CP, Wiggans G, Rothschild MF.

PLoS One. 2015 Jul 8;10(7):e0129967. doi: 10.1371/journal.pone.0129967. eCollection 2015.

15.

Genomic runs of homozygosity record population history and consanguinity.

Kirin M, McQuillan R, Franklin CS, Campbell H, McKeigue PM, Wilson JF.

PLoS One. 2010 Nov 15;5(11):e13996. doi: 10.1371/journal.pone.0013996.

16.

Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha.

Carroll LS, Williams NM, Moskvina V, Russell E, Norton N, Williams HJ, Peirce T, Georgieva L, Dwyer S, Grozeva D, Greene E, Farmer A, McGuffin P, Morris DW, Corvin A, Gill M, Rujescu D, Sham P, Holmans P, Jones I, Kirov G, Craddock N, O'Donovan MC, Owen MJ.

Mol Psychiatry. 2010 Nov;15(11):1101-11. doi: 10.1038/mp.2009.96. Epub 2009 Sep 29.

PMID:
19786960
17.

ATA homozigosity in the IL-10 gene promoter is a risk factor for schizophrenia in Spanish females: a case control study.

Almoguera B, Riveiro-Alvarez R, Lopez-Castroman J, Dorado P, Lopez-Rodriguez R, Fernandez-Navarro P, Baca-García E, Fernandez-Piqueras J, Dal-Ré R, Abad-Santos F, Llerena A, Ayuso C; Spanish Consortium of Pharmacogenetics Research in Schizophrenia.

BMC Med Genet. 2011 Jun 9;12:81. doi: 10.1186/1471-2350-12-81.

18.

Extended tracts of homozygosity in outbred human populations.

Gibson J, Morton NE, Collins A.

Hum Mol Genet. 2006 Mar 1;15(5):789-95. Epub 2006 Jan 25.

PMID:
16436455
19.

Evidence of recessive Alzheimer disease loci in a Caribbean Hispanic data set: genome-wide survey of runs of homozygosity.

Ghani M, Sato C, Lee JH, Reitz C, Moreno D, Mayeux R, St George-Hyslop P, Rogaeva E.

JAMA Neurol. 2013 Oct;70(10):1261-7. doi: 10.1001/jamaneurol.2013.3545.

20.

Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories.

Córdova-Palomera A, Kaufmann T, Bettella F, Wang Y, Doan NT, van der Meer D, Alnæs D, Rokicki J, Moberget T, Sønderby IE, Andreassen OA, Westlye LT.

Eur J Hum Genet. 2018 Jul;26(7):1049-1059. doi: 10.1038/s41431-018-0134-2. Epub 2018 Apr 27.

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