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Items: 1 to 20 of 132

1.

Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β3-adrenoceptor agonist.

Takusagawa S, Yajima K, Miyashita A, Uehara S, Iwatsubo T, Usui T.

Xenobiotica. 2012 Oct;42(10):957-67. doi: 10.3109/00498254.2012.675095. Epub 2012 Apr 18.

PMID:
22509825
2.

In vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective β3-adrenoceptor agonist.

Takusagawa S, Miyashita A, Iwatsubo T, Usui T.

Xenobiotica. 2012 Dec;42(12):1187-96. doi: 10.3109/00498254.2012.700140. Epub 2012 Jul 27.

PMID:
22834478
3.

Absorption, metabolism and excretion of [(14)C]mirabegron (YM178), a potent and selective β(3)-adrenoceptor agonist, after oral administration to healthy male volunteers.

Takusagawa S, van Lier JJ, Suzuki K, Nagata M, Meijer J, Krauwinkel W, Schaddelee M, Sekiguchi M, Miyashita A, Iwatsubo T, van Gelderen M, Usui T.

Drug Metab Dispos. 2012 Apr;40(4):815-24. doi: 10.1124/dmd.111.043588. Epub 2012 Jan 23.

4.

Role of cytochrome p450 isoenzymes 3A and 2D6 in the in vivo metabolism of mirabegron, a β3-adrenoceptor agonist.

Lee J, Moy S, Meijer J, Krauwinkel W, Sawamoto T, Kerbusch V, Kowalski D, Roy M, Marion A, Takusagawa S, van Gelderen M, Keirns J.

Clin Drug Investig. 2013 Jun;33(6):429-40. doi: 10.1007/s40261-013-0084-y.

PMID:
23625188
5.

Identification of cytochrome P450 isoforms involved in the metabolism of paroxetine and estimation of their importance for human paroxetine metabolism using a population-based simulator.

Jornil J, Jensen KG, Larsen F, Linnet K.

Drug Metab Dispos. 2010 Mar;38(3):376-85. doi: 10.1124/dmd.109.030551. Epub 2009 Dec 10.

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Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine.

Beulz-Riché D, Grudé P, Puozzo C, Sautel F, Filaquier C, Riché C, Ratanasavanh D.

Fundam Clin Pharmacol. 2005 Oct;19(5):545-53.

PMID:
16176333
9.
10.

Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms.

Renwick AB, Surry D, Price RJ, Lake BG, Evans DC.

Xenobiotica. 2000 Oct;30(10):955-69.

PMID:
11315104
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13.

Characterization of human cytochrome P450 enzymes involved in the in vitro metabolism of perospirone.

Kitamura A, Mizuno Y, Natsui K, Yabuki M, Komuro S, Kanamaru H.

Biopharm Drug Dispos. 2005 Mar;26(2):59-65.

PMID:
15619261
14.

Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism.

Mei Q, Tang C, Assang C, Lin Y, Slaughter D, Rodrigues AD, Baillie TA, Rushmore TH, Shou M.

J Pharmacol Exp Ther. 1999 Nov;291(2):749-59.

15.

Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes.

Jang GR, Wrighton SA, Benet LZ.

Biochem Pharmacol. 1996 Sep 13;52(5):753-61.

PMID:
8765473
16.

Metabolism of the active metabolite of quetiapine, N-desalkylquetiapine in vitro.

Bakken GV, Molden E, Knutsen K, Lunder N, Hermann M.

Drug Metab Dispos. 2012 Sep;40(9):1778-84. doi: 10.1124/dmd.112.045237. Epub 2012 Jun 11.

17.

Inhibition kinetics of monoclonal antibodies against cytochromes P450.

Mei Q, Tang C, Lin Y, Rushmore TH, Shou M.

Drug Metab Dispos. 2002 Jun;30(6):701-8.

18.

In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

Projean D, Baune B, Farinotti R, Flinois JP, Beaune P, Taburet AM, Ducharme J.

Drug Metab Dispos. 2003 Jun;31(6):748-54.

19.

CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes.

Hutchinson MR, Menelaou A, Foster DJ, Coller JK, Somogyi AA.

Br J Clin Pharmacol. 2004 Mar;57(3):287-97.

20.

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