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A molecular model for the differential activation of STAT3 and STAT6 by the herpesviral oncoprotein tip.

Mazumder ED, Jardin C, Vogel B, Heck E, Scholz B, Lengenfelder D, Sticht H, Ensser A.

PLoS One. 2012;7(4):e34306. doi: 10.1371/journal.pone.0034306. Epub 2012 Apr 3.


T-cell growth transformation by herpesvirus saimiri is independent of STAT3 activation.

Heck E, Lengenfelder D, Schmidt M, Müller-Fleckenstein I, Fleckenstein B, Biesinger B, Ensser A.

J Virol. 2005 May;79(9):5713-20.


Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs.

Heck E, Friedrich U, Gack MU, Lengenfelder D, Schmidt M, Müller-Fleckenstein I, Fleckenstein B, Ensser A, Biesinger B.

J Virol. 2006 Oct;80(20):9934-42.


Tyrosine phosphorylation of the Tio oncoprotein is essential for transformation of primary human T cells.

Albrecht JC, Müller-Fleckenstein I, Schmidt M, Fleckenstein B, Biesinger B.

J Virol. 2005 Aug;79(16):10507-13.


Activation of the Lck tyrosine protein kinase by the Herpesvirus saimiri tip protein involves two binding interactions.

Hartley DA, Amdjadi K, Hurley TR, Lund TC, Medveczky PG, Sefton BM.

Virology. 2000 Oct 25;276(2):339-48.


Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

Garcia R, Yu CL, Hudnall A, Catlett R, Nelson KL, Smithgall T, Fujita DJ, Ethier SP, Jove R.

Cell Growth Differ. 1997 Dec;8(12):1267-76.


Characterization of molecular recognition of STAT3 SH2 domain inhibitors through molecular simulation.

Park IH, Li C.

J Mol Recognit. 2011 Mar-Apr;24(2):254-65. doi: 10.1002/jmr.1047.


Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.

Schreiner SJ, Schiavone AP, Smithgall TE.

J Biol Chem. 2002 Nov 22;277(47):45680-7. Epub 2002 Sep 19.


Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck.

Lund TC, Garcia R, Medveczky MM, Jove R, Medveczky PG.

J Virol. 1997 Sep;71(9):6677-82.


Mutational analysis of the STAT6 SH2 domain.

Mikita T, Daniel C, Wu P, Schindler U.

J Biol Chem. 1998 Jul 10;273(28):17634-42.


Characterization of Lck-binding elements in the herpesviral regulatory Tip protein.

Bauer F, Hofinger E, Hoffmann S, Rösch P, Schweimer K, Sticht H.

Biochemistry. 2004 Nov 30;43(47):14932-9.


Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation.

Hemmann U, Gerhartz C, Heesel B, Sasse J, Kurapkat G, Grötzinger J, Wollmer A, Zhong Z, Darnell JE Jr, Graeve L, Heinrich PC, Horn F.

J Biol Chem. 1996 May 31;271(22):12999-3007.


Activation of the STAT6 transcription factor in Jurkat T-cells by the herpesvirus saimiri Tip protein.

Kim Y, Kwon EK, Jeon JH, So I, Kim IG, Choi MS, Kim IS, Choi JK, Jung JU, Cho NH.

J Gen Virol. 2012 Feb;93(Pt 2):330-40. doi: 10.1099/vir.0.036087-0. Epub 2011 Oct 19.


Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins.

Takakuma K, Ogo N, Uehara Y, Takahashi S, Miyoshi N, Asai A.

PLoS One. 2013 Aug 16;8(8):e71646. doi: 10.1371/journal.pone.0071646. eCollection 2013.


Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck.

Schweimer K, Hoffmann S, Bauer F, Friedrich U, Kardinal C, Feller SM, Biesinger B, Sticht H.

Biochemistry. 2002 Apr 23;41(16):5120-30.


Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation.

Shi CS, Kehrl JH.

J Biol Chem. 2004 Apr 23;279(17):17224-31. Epub 2004 Feb 12.


The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells.

Lund TC, Prator PC, Medveczky MM, Medveczky PG.

J Virol. 1999 Feb;73(2):1689-94.

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