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Items: 1 to 20 of 87

1.

Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis.

Mutoh T, Kawamura N, Hirabayashi Y, Shima S, Miyashita T, Ito S, Asakura K, Araki W, Cazzaniga E, Muto E, Masserini M.

FASEB J. 2012 Jul;26(7):3065-74. doi: 10.1096/fj.11-198630. Epub 2012 Apr 16.

PMID:
22508690
2.

Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.

Ma L, Ohyagi Y, Miyoshi K, Sakae N, Motomura K, Taniwaki T, Furuya H, Takeda K, Tabira T, Kira J.

J Alzheimers Dis. 2009;16(3):565-75. doi: 10.3233/JAD-2009-0990.

PMID:
19276551
3.

Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors.

Miyoshi K, Ohyagi Y, Sakae N, Motomura K, Ma L, Taniwaki T, Furuya H, Tabira T, Kira J.

J Alzheimers Dis. 2009;16(3):551-64. doi: 10.3233/JAD-2009-0989.

PMID:
19276550
4.

Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein.

Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H.

Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):70-6. Epub 2005 Mar 19.

PMID:
15950763
5.

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S.

J Biol Chem. 2007 Aug 24;282(34):24504-13. Epub 2007 Jun 15.

6.

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.

Page RM, Baumann K, Tomioka M, PĂ©rez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C.

J Biol Chem. 2008 Jan 11;283(2):677-83. Epub 2007 Oct 24.

7.

Identification of gamma-secretase inhibitor potency determinants on presenilin.

Zhao B, Yu M, Neitzel M, Marugg J, Jagodzinski J, Lee M, Hu K, Schenk D, Yednock T, Basi G.

J Biol Chem. 2008 Feb 1;283(5):2927-38. Epub 2007 Nov 21.

8.

Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

Kuzuya A, Uemura K, Kitagawa N, Aoyagi N, Kihara T, Ninomiya H, Ishiura S, Takahashi R, Shimohama S.

J Neurosci Res. 2007 Jan;85(1):153-65.

PMID:
17075903
9.

Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.

Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.

Neurosci Res. 2007 Mar;57(3):446-53. Epub 2007 Jan 8.

PMID:
17210196
10.

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A.

J Biol Chem. 2008 Jun 13;283(24):16488-96. doi: 10.1074/jbc.M801279200. Epub 2008 Apr 21.

11.
12.

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.

Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR.

Hum Mol Genet. 2004 Jan 15;13(2):159-70. Epub 2003 Nov 25.

PMID:
14645205
13.

Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.

Qi Y, Morishima-Kawashima M, Sato T, Mitsumori R, Ihara Y.

Biochemistry. 2003 Feb 4;42(4):1042-52.

PMID:
12549925
14.
15.

Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.

Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T.

J Neurosci. 2007 Nov 28;27(48):13092-7.

16.

Chinese Presenilin-1 V97L mutation enhanced Abeta42 levels in SH-SY5Y neuroblastoma cells.

Fang B, Jia L, Jia J.

Neurosci Lett. 2006 Oct 2;406(1-2):33-7. Epub 2006 Aug 17.

PMID:
16916581
17.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
18.

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

Evin G, Sharples RA, Weidemann A, Reinhard FB, Carbone V, Culvenor JG, Holsinger RM, Sernee MF, Beyreuther K, Masters CL.

Biochemistry. 2001 Jul 27;40(28):8359-68.

PMID:
11444983
19.

The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.

Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA.

Exp Neurol. 2004 Aug;188(2):224-37.

PMID:
15246822
20.

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