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Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action.

Soumyanath A, Zhong YP, Henson E, Wadsworth T, Bishop J, Gold BG, Quinn JF.

Int J Alzheimers Dis. 2012;2012:381974. doi: 10.1155/2012/381974. Epub 2012 Feb 15.


Caffeoylquinic acids in Centella asiatica protect against amyloid-β toxicity.

Gray NE, Morré J, Kelley J, Maier CS, Stevens JF, Quinn JF, Soumyanath A.

J Alzheimers Dis. 2014;40(2):359-73. doi: 10.3233/JAD-131913. Erratum in: J Alzheimers Dis. 2014;41(3):957.


Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.

Xu MF, Xiong YY, Liu JK, Qian JJ, Zhu L, Gao J.

Acta Pharmacol Sin. 2012 May;33(5):578-87. doi: 10.1038/aps.2012.3. Epub 2012 Mar 26.


Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential.

Orhan IE.

Evid Based Complement Alternat Med. 2012;2012:946259. doi: 10.1155/2012/946259. Epub 2012 May 14.


Centella asiatica attenuates Aβ-induced neurodegenerative spine loss and dendritic simplification.

Gray NE, Zweig JA, Murchison C, Caruso M, Matthews DG, Kawamoto C, Harris CJ, Quinn JF, Soumyanath A.

Neurosci Lett. 2017 Apr 12;646:24-29. doi: 10.1016/j.neulet.2017.02.072. Epub 2017 Mar 6.


Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model.

Dhanasekaran M, Holcomb LA, Hitt AR, Tharakan B, Porter JW, Young KA, Manyam BV.

Phytother Res. 2009 Jan;23(1):14-9. doi: 10.1002/ptr.2405.


Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro.

Soumyanath A, Zhong YP, Gold SA, Yu X, Koop DR, Bourdette D, Gold BG.

J Pharm Pharmacol. 2005 Sep;57(9):1221-9.


In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica.

Pan Y, Abd-Rashid BA, Ismail Z, Ismail R, Mak JW, Pook PC, Er HM, Ong CE.

J Ethnopharmacol. 2010 Jul 20;130(2):275-83. doi: 10.1016/j.jep.2010.05.002. Epub 2010 May 8.


Centella asiatica extract protects against amyloid β1-40-induced neurotoxicity in neuronal cells by activating the antioxidative defence system.

Chen CL, Tsai WH, Chen CJ, Pan TM.

J Tradit Complement Med. 2015 Aug 1;6(4):362-369. eCollection 2016 Oct.


Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress.

Kumar A, Dogra S, Prakash A.

Int J Alzheimers Dis. 2009 Sep 13;2009. pii: 972178. doi: 10.4061/2009/972178.


Recent Updates in Neuroprotective and Neuroregenerative Potential of Centella asiatica.

Lokanathan Y, Omar N, Ahmad Puzi NN, Saim A, Hj Idrus R.

Malays J Med Sci. 2016 Jan;23(1):4-14. Review.


Gotu Kola (Centella asiatica): Nutritional Properties and Plausible Health Benefits.

Chandrika UG, Prasad Kumarab PA.

Adv Food Nutr Res. 2015;76:125-57. doi: 10.1016/bs.afnr.2015.08.001. Epub 2015 Oct 1. Review.


The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to β-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment.

Ostapchenko VG, Chen M, Guzman MS, Xie YF, Lavine N, Fan J, Beraldo FH, Martyn AC, Belrose JC, Mori Y, MacDonald JF, Prado VF, Prado MA, Jackson MF.

J Neurosci. 2015 Nov 11;35(45):15157-69. doi: 10.1523/JNEUROSCI.4081-14.2015.


L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease.

Peng Y, Sun J, Hon S, Nylander AN, Xia W, Feng Y, Wang X, Lemere CA.

J Neurosci. 2010 Jun 16;30(24):8180-9. doi: 10.1523/JNEUROSCI.0340-10.2010.


Identification of Centella asiatica's Effective Ingredients for Inducing the Neuronal Differentiation.

Jiang H, Zheng G, Lv J, Chen H, Lin J, Li Y, Fan G, Ding X.

Evid Based Complement Alternat Med. 2016;2016:9634750. doi: 10.1155/2016/9634750. Epub 2016 Jun 30.


Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology.

Isopi E, Granzotto A, Corona C, Bomba M, Ciavardelli D, Curcio M, Canzoniero LM, Navarra R, Lattanzio R, Piantelli M, Sensi SL.

Neurobiol Dis. 2015 Sep;81:214-24. doi: 10.1016/j.nbd.2014.11.013. Epub 2014 Nov 28.


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