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Items: 1 to 20 of 96

1.

Impacts of dystrophin and utrophin domains on actin structural dynamics: implications for therapeutic design.

Lin AY, Prochniewicz E, Henderson DM, Li B, Ervasti JM, Thomas DD.

J Mol Biol. 2012 Jun 29;420(1-2):87-98. doi: 10.1016/j.jmb.2012.04.005. Epub 2012 Apr 11.

2.

Dystrophin and utrophin have distinct effects on the structural dynamics of actin.

Prochniewicz E, Henderson D, Ervasti JM, Thomas DD.

Proc Natl Acad Sci U S A. 2009 May 12;106(19):7822-7. doi: 10.1073/pnas.0812007106. Epub 2009 Apr 30.

3.

An atomic model for actin binding by the CH domains and spectrin-repeat modules of utrophin and dystrophin.

Sutherland-Smith AJ, Moores CA, Norwood FL, Hatch V, Craig R, Kendrick-Jones J, Lehman W.

J Mol Biol. 2003 May 23;329(1):15-33.

PMID:
12742015
4.

Large-scale opening of utrophin's tandem calponin homology (CH) domains upon actin binding by an induced-fit mechanism.

Lin AY, Prochniewicz E, James ZM, Svensson B, Thomas DD.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12729-33. doi: 10.1073/pnas.1106453108. Epub 2011 Jul 18.

5.

The N- and C-Terminal Domains Differentially Contribute to the Structure and Function of Dystrophin and Utrophin Tandem Calponin-Homology Domains.

Singh SM, Bandi S, Mallela KM.

Biochemistry. 2015 Nov 24;54(46):6942-50. doi: 10.1021/acs.biochem.5b00969. Epub 2015 Nov 13.

PMID:
26516677
6.

The crystal structures of dystrophin and utrophin spectrin repeats: implications for domain boundaries.

Muthu M, Richardson KA, Sutherland-Smith AJ.

PLoS One. 2012;7(7):e40066. doi: 10.1371/journal.pone.0040066. Epub 2012 Jul 20.

7.

Structural comparison of actin binding in utrophin and dystrophin.

Keep NH.

Neurol Sci. 2000;21(5 Suppl):S929-37. Review.

PMID:
11382192
8.

Interdomain Linker Determines Primarily the Structural Stability of Dystrophin and Utrophin Tandem Calponin-Homology Domains Rather than Their Actin-Binding Affinity.

Bandi S, Singh SM, Mallela KM.

Biochemistry. 2015 Sep 8;54(35):5480-8. doi: 10.1021/acs.biochem.5b00741. Epub 2015 Aug 26.

PMID:
26288220
9.

Flexibility in the N-terminal actin-binding domain: clues from in silico mutations and molecular dynamics.

Chakravarty D, Chakraborti S, Chakrabarti P.

Proteins. 2015 Apr;83(4):696-710. doi: 10.1002/prot.24767. Epub 2015 Feb 5.

PMID:
25620004
10.

Dystrophin and utrophin bind actin through distinct modes of contact.

Rybakova IN, Humston JL, Sonnemann KJ, Ervasti JM.

J Biol Chem. 2006 Apr 14;281(15):9996-10001. Epub 2006 Feb 13.

11.

Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer.

Keep NH, Winder SJ, Moores CA, Walke S, Norwood FL, Kendrick-Jones J.

Structure. 1999 Dec 15;7(12):1539-46.

12.

Internal deletion compromises the stability of dystrophin.

Henderson DM, Belanto JJ, Li B, Heun-Johnson H, Ervasti JM.

Hum Mol Genet. 2011 Aug 1;20(15):2955-63. doi: 10.1093/hmg/ddr199. Epub 2011 May 10.

13.
14.

Restoration of all dystrophin protein interactions by functional domains in trans does not rescue dystrophy.

Gardner KL, Kearney JA, Edwards JD, Rafael-Fortney JA.

Gene Ther. 2006 May;13(9):744-51.

PMID:
16307000
15.

[Development of new therapy on muscular dystrophy].

Takeda S.

Rinsho Shinkeigaku. 2001 Dec;41(12):1154-6. Review. Japanese.

PMID:
12235824
16.

ZZ domain is essentially required for the physiological binding of dystrophin and utrophin to beta-dystroglycan.

Ishikawa-Sakurai M, Yoshida M, Imamura M, Davies KE, Ozawa E.

Hum Mol Genet. 2004 Apr 1;13(7):693-702. Epub 2004 Feb 12.

PMID:
14962982
17.

Gene therapy research for Duchenne and Becker muscular dystrophies.

Karpati G, Gilbert R, Petrof BJ, Nalbantoglu J.

Curr Opin Neurol. 1997 Oct;10(5):430-5. Review.

PMID:
9330891
18.

Thermodynamic stability, unfolding kinetics, and aggregation of the N-terminal actin-binding domains of utrophin and dystrophin.

Singh SM, Molas JF, Kongari N, Bandi S, Armstrong GS, Winder SJ, Mallela KM.

Proteins. 2012 May;80(5):1377-92. doi: 10.1002/prot.24033. Epub 2012 Feb 17.

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