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Items: 1 to 20 of 142

1.

Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells.

Liberman AC, Antunica-Noguerol M, Ferraz-de-Paula V, Palermo-Neto J, Castro CN, Druker J, Holsboer F, Perone MJ, Gerlo S, De Bosscher K, Haegeman G, Arzt E.

PLoS One. 2012;7(4):e35155. doi: 10.1371/journal.pone.0035155. Erratum in: PLoS One. 2012;7(5): doi/10.1371/annotation/12a8fc89-5f47-4bad-8863-863d99a0e52d.

2.

A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma.

Reber LL, Daubeuf F, Plantinga M, De Cauwer L, Gerlo S, Waelput W, Van Calenbergh S, Tavernier J, Haegeman G, Lambrecht BN, Frossard N, De Bosscher K.

J Immunol. 2012 Apr 1;188(7):3478-87. doi: 10.4049/jimmunol.1004227.

3.
4.

Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells.

Liberman AC, Druker J, Refojo D, Holsboer F, Arzt E.

FASEB J. 2009 May;23(5):1558-71. doi: 10.1096/fj.08-121236.

PMID:
19124555
5.

T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.

Usui T, Preiss JC, Kanno Y, Yao ZJ, Bream JH, O'Shea JJ, Strober W.

J Exp Med. 2006 Mar 20;203(3):755-66. Erratum in: J Exp Med. 2006 Apr 17;203(4):1129.

6.

Immunoregulatory effects of sinomenine on the T-bet/GATA-3 ratio and Th1/Th2 cytokine balance in the treatment of mesangial proliferative nephritis.

Cheng Y, Zhang J, Hou W, Wang D, Li F, Zhang Y, Yuan F.

Int Immunopharmacol. 2009 Jul;9(7-8):894-9. doi: 10.1016/j.intimp.2009.03.014.

PMID:
19336263
7.

Quercetin regulates Th1/Th2 balance in a murine model of asthma.

Park HJ, Lee CM, Jung ID, Lee JS, Jeong YI, Chang JH, Chun SH, Kim MJ, Choi IW, Ahn SC, Shin YK, Yeom SR, Park YM.

Int Immunopharmacol. 2009 Mar;9(3):261-7. doi: 10.1016/j.intimp.2008.10.021.

PMID:
19061976
8.

[Imbalanced T cell-specific transcription factors T-bet and GATA-3 contributes to type 2 T helper cell polarization in asthmatic patients].

Liu CT, Wang G, Luo FM, Wang ZL, Liu R, Wang CL.

Zhonghua Jie He He Hu Xi Za Zhi. 2004 Jun;27(6):398-402. Chinese.

PMID:
15256090
9.

T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3.

Chakir H, Wang H, Lefebvre DE, Webb J, Scott FW.

J Immunol Methods. 2003 Jul;278(1-2):157-69.

PMID:
12957404
10.

Double deficiency for RORγt and T-bet drives Th2-mediated allograft rejection in mice.

Sabet-Baktach M, Eggenhofer E, Rovira J, Renner P, Lantow M, Farkas SA, Malaisé M, Edtinger K, Shaotang Z, Koehl GE, Dahlke MH, Schlitt HJ, Geissler EK, Kroemer A.

J Immunol. 2013 Oct 15;191(8):4440-6. doi: 10.4049/jimmunol.1301741.

11.

Transcription factors T-bet and GATA-3 regulate development of airway remodeling.

Kiwamoto T, Ishii Y, Morishima Y, Yoh K, Maeda A, Ishizaki K, Iizuka T, Hegab AE, Matsuno Y, Homma S, Nomura A, Sakamoto T, Takahashi S, Sekizawa K.

Am J Respir Crit Care Med. 2006 Jul 15;174(2):142-51.

PMID:
16614350
12.

Heat shock protein 60 inhibits Th1-mediated hepatitis model via innate regulation of Th1/Th2 transcription factors and cytokines.

Zanin-Zhorov A, Bruck R, Tal G, Oren S, Aeed H, Hershkoviz R, Cohen IR, Lider O.

J Immunol. 2005 Mar 15;174(6):3227-36.

13.
14.

Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis.

Wüst S, Tischner D, John M, Tuckermann JP, Menzfeld C, Hanisch UK, van den Brandt J, Lühder F, Reichardt HM.

PLoS One. 2009 Dec 7;4(12):e8202. doi: 10.1371/journal.pone.0008202.

15.

Effect of immune modulation therapy on cardiac function and T-bet/GATA-3 gene expression in aging male patients with chronic cardiac insufficiency.

Han LN, Guo SL, Li TL, Ding GL, Zhang YJ, Ma JL.

Immunotherapy. 2013 Feb;5(2):143-53. doi: 10.2217/imt.12.139.

PMID:
23413906
16.

Stemucronatoside L, a pregnane glycoside from the roots of Stephanotis mucronata, inhibits Th1/Th2 immune responses in vitro.

Chen FY, Ye YP, Sun HX, Li XY, Shi H.

Chem Biodivers. 2009 Jun;6(6):916-23. doi: 10.1002/cbdv.200800159.

PMID:
19551733
17.

Shenghua Decoction reduces uterine bleeding and regulates T-cell paradigm in human deciduas of RU486 medical abortion.

Li X, Zhang M, Wang B, Li Y, Wang L, Zhao X, Zhou X, Guo Y, Jiang G, Yao C.

J Ethnopharmacol. 2013 Dec 12;150(3):907-17. doi: 10.1016/j.jep.2013.09.033.

PMID:
24140602
18.

Downregulation of T-bet/GATA-3 ratio induced by IL-11 treatment is responsible for Th1/Th2 balance restoration in human immune thrombocytopenic purpura (ITP).

Yao R, Lin Y, Li Q, Zhou X, Pan X, Bao Y, He M, Zhu B, Guo W, Lin X, Jin L.

J Thromb Thrombolysis. 2014;38(2):183-9. doi: 10.1007/s11239-013-1036-3.

PMID:
24338248
19.

A fully dissociated compound of plant origin for inflammatory gene repression.

De Bosscher K, Vanden Berghe W, Beck IM, Van Molle W, Hennuyer N, Hapgood J, Libert C, Staels B, Louw A, Haegeman G.

Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15827-32.

20.

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