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Comparative analysis of Mycobacterium tuberculosis pe and ppe genes reveals high sequence variation and an apparent absence of selective constraints.

McEvoy CR, Cloete R, Müller B, Schürch AC, van Helden PD, Gagneux S, Warren RM, Gey van Pittius NC.

PLoS One. 2012;7(4):e30593. doi: 10.1371/journal.pone.0030593. Epub 2012 Apr 4.


Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition.

Copin R, Coscollá M, Seiffert SN, Bothamley G, Sutherland J, Mbayo G, Gagneux S, Ernst JD.

MBio. 2014 Jan 14;5(1):e00960-13. doi: 10.1128/mBio.00960-13.


Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region.

McEvoy CR, van Helden PD, Warren RM, Gey van Pittius NC.

BMC Evol Biol. 2009 Sep 21;9:237. doi: 10.1186/1471-2148-9-237.


Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium tuberculosis lineages.

Phelan JE, Coll F, Bergval I, Anthony RM, Warren R, Sampson SL, Gey van Pittius NC, Glynn JR, Crampin AC, Alves A, Bessa TB, Campino S, Dheda K, Grandjean L, Hasan R, Hasan Z, Miranda A, Moore D, Panaiotov S, Perdigao J, Portugal I, Sheen P, de Oliveira Sousa E, Streicher EM, van Helden PD, Viveiros M, Hibberd ML, Pain A, McNerney R, Clark TG.

BMC Genomics. 2016 Feb 29;17:151. doi: 10.1186/s12864-016-2467-y.


Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity.

Fishbein S, van Wyk N, Warren RM, Sampson SL.

Mol Microbiol. 2015 Jun;96(5):901-16. doi: 10.1111/mmi.12981. Epub 2015 Mar 30. Review.


Regulation of the Mycobacterium tuberculosis PE/PPE genes.

Voskuil MI, Schnappinger D, Rutherford R, Liu Y, Schoolnik GK.

Tuberculosis (Edinb). 2004;84(3-4):256-62.


Frequent homologous recombination events in Mycobacterium tuberculosis PE/PPE multigene families: potential role in antigenic variability.

Karboul A, Mazza A, Gey van Pittius NC, Ho JL, Brousseau R, Mardassi H.

J Bacteriol. 2008 Dec;190(23):7838-46. doi: 10.1128/JB.00827-08. Epub 2008 Sep 26.


The Enigmatic PE/PPE Multigene Family of Mycobacteria and Tuberculosis Vaccination.

Brennan MJ.

Infect Immun. 2017 May 23;85(6). pii: e00969-16. doi: 10.1128/IAI.00969-16. Print 2017 Jun. Review.


Variation of the Mycobacterium tuberculosis PE_PGRS 33 gene among clinical isolates.

Talarico S, Cave MD, Marrs CF, Foxman B, Zhang L, Yang Z.

J Clin Microbiol. 2005 Oct;43(10):4954-60.


Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.

Fleischmann RD, Alland D, Eisen JA, Carpenter L, White O, Peterson J, DeBoy R, Dodson R, Gwinn M, Haft D, Hickey E, Kolonay JF, Nelson WC, Umayam LA, Ermolaeva M, Salzberg SL, Delcher A, Utterback T, Weidman J, Khouri H, Gill J, Mikula A, Bishai W, Jacobs Jr WR Jr, Venter JC, Fraser CM.

J Bacteriol. 2002 Oct;184(19):5479-90.


Evolution of smooth tubercle Bacilli PE and PE_PGRS genes: evidence for a prominent role of recombination and imprint of positive selection.

Namouchi A, Karboul A, Fabre M, Gutierrez MC, Mardassi H.

PLoS One. 2013 May 21;8(5):e64718. doi: 10.1371/journal.pone.0064718. Print 2013.


Genes under positive selection in Mycobacterium tuberculosis.

Zhang Y, Zhang H, Zhou T, Zhong Y, Jin Q.

Comput Biol Chem. 2011 Oct 12;35(5):319-22. doi: 10.1016/j.compbiolchem.2011.08.001. Epub 2011 Aug 19.


Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential.

Sayes F, Sun L, Di Luca M, Simeone R, Degaiffier N, Fiette L, Esin S, Brosch R, Bottai D, Leclerc C, Majlessi L.

Cell Host Microbe. 2012 Apr 19;11(4):352-63. doi: 10.1016/j.chom.2012.03.003.


Immunoregulatory functions and expression patterns of PE/PPE family members: Roles in pathogenicity and impact on anti-tuberculosis vaccine and drug design.

Ahmed A, Das A, Mukhopadhyay S.

IUBMB Life. 2015 Jun;67(6):414-27. doi: 10.1002/iub.1387. Epub 2015 Jun 24. Review.


Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.

Zheng H, Lu L, Wang B, Pu S, Zhang X, Zhu G, Shi W, Zhang L, Wang H, Wang S, Zhao G, Zhang Y.

PLoS One. 2008 Jun 11;3(6):e2375. doi: 10.1371/journal.pone.0002375.


Comparative genomic analysis of Mycobacterium tuberculosis clinical isolates.

Liu F, Hu Y, Wang Q, Li HM, Gao GF, Liu CH, Zhu B.

BMC Genomics. 2014 Jun 13;15:469. doi: 10.1186/1471-2164-15-469.


Mycobacterium tuberculosis PE_PGRS16 and PE_PGRS26 genetic polymorphism among clinical isolates.

Talarico S, Zhang L, Marrs CF, Foxman B, Cave MD, Brennan MJ, Yang Z.

Tuberculosis (Edinb). 2008 Jul;88(4):283-94. doi: 10.1016/ Epub 2008 Mar 4.


Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion.

Ekiert DC, Cox JS.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14758-63. doi: 10.1073/pnas.1409345111. Epub 2014 Oct 1.


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